The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism
Alzheimer’s disease (AD), the most common type of senile dementia, includes the complex pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p-tau) and neuroimmune inflammatory. The neurodegenerative process of AD triggers microglial activation, and the overactivatio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.888989/full |
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| author | Hui-Zhi Long Hui-Zhi Long Zi-Wei Zhou Zi-Wei Zhou Yan Cheng Yan Cheng Hong-Yu Luo Hong-Yu Luo Feng-Jiao Li Feng-Jiao Li Shuo-Guo Xu Shuo-Guo Xu Li-Chen Gao Li-Chen Gao |
| author_facet | Hui-Zhi Long Hui-Zhi Long Zi-Wei Zhou Zi-Wei Zhou Yan Cheng Yan Cheng Hong-Yu Luo Hong-Yu Luo Feng-Jiao Li Feng-Jiao Li Shuo-Guo Xu Shuo-Guo Xu Li-Chen Gao Li-Chen Gao |
| author_sort | Hui-Zhi Long |
| collection | DOAJ |
| description | Alzheimer’s disease (AD), the most common type of senile dementia, includes the complex pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p-tau) and neuroimmune inflammatory. The neurodegenerative process of AD triggers microglial activation, and the overactivation of microglia produces a large number of neuroimmune inflammatory factors. Microglia dysfunction can lead to disturbances in iron metabolism and enhance iron-induced neuronal degeneration in AD, while elevated iron levels in brain areas affect microglia phenotype and function. In this manuscript, we firstly discuss the role of microglia in AD and then introduce the role of microglia in the immune-inflammatory pathology of AD. Their role in AD iron homeostasis is emphasized. Recent studies on microglia and ferroptosis in AD are also reviewed. It will help readers better understand the role of microglia in iron metabolism in AD, and provides a basis for better regulation of iron metabolism disorders in AD and the discovery of new potential therapeutic targets for AD. |
| first_indexed | 2024-12-12T11:42:58Z |
| format | Article |
| id | doaj.art-d6ab2b8c9fcc410581ef6031be4f2e73 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T11:42:58Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-d6ab2b8c9fcc410581ef6031be4f2e732022-12-22T00:25:30ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-06-011410.3389/fnagi.2022.888989888989The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron MetabolismHui-Zhi Long0Hui-Zhi Long1Zi-Wei Zhou2Zi-Wei Zhou3Yan Cheng4Yan Cheng5Hong-Yu Luo6Hong-Yu Luo7Feng-Jiao Li8Feng-Jiao Li9Shuo-Guo Xu10Shuo-Guo Xu11Li-Chen Gao12Li-Chen Gao13School of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaSchool of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaSchool of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaSchool of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaSchool of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaSchool of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaSchool of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaAlzheimer’s disease (AD), the most common type of senile dementia, includes the complex pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p-tau) and neuroimmune inflammatory. The neurodegenerative process of AD triggers microglial activation, and the overactivation of microglia produces a large number of neuroimmune inflammatory factors. Microglia dysfunction can lead to disturbances in iron metabolism and enhance iron-induced neuronal degeneration in AD, while elevated iron levels in brain areas affect microglia phenotype and function. In this manuscript, we firstly discuss the role of microglia in AD and then introduce the role of microglia in the immune-inflammatory pathology of AD. Their role in AD iron homeostasis is emphasized. Recent studies on microglia and ferroptosis in AD are also reviewed. It will help readers better understand the role of microglia in iron metabolism in AD, and provides a basis for better regulation of iron metabolism disorders in AD and the discovery of new potential therapeutic targets for AD.https://www.frontiersin.org/articles/10.3389/fnagi.2022.888989/fullAlzheimer’s diseasemicrogliairon metabolismAβimmune inflammation |
| spellingShingle | Hui-Zhi Long Hui-Zhi Long Zi-Wei Zhou Zi-Wei Zhou Yan Cheng Yan Cheng Hong-Yu Luo Hong-Yu Luo Feng-Jiao Li Feng-Jiao Li Shuo-Guo Xu Shuo-Guo Xu Li-Chen Gao Li-Chen Gao The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism Frontiers in Aging Neuroscience Alzheimer’s disease microglia iron metabolism Aβ immune inflammation |
| title | The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism |
| title_full | The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism |
| title_fullStr | The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism |
| title_full_unstemmed | The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism |
| title_short | The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism |
| title_sort | role of microglia in alzheimer s disease from the perspective of immune inflammation and iron metabolism |
| topic | Alzheimer’s disease microglia iron metabolism Aβ immune inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.888989/full |
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