Discrepant expressive language lateralization in children and adolescents with epilepsy
Abstract Neuronavigated transcranial magnetic stimulation (nTMS) has emerged as a presurgical language mapping tool distinct from the widely used functional magnetic resonance imaging (fMRI). We report fMRI and nTMS language‐mapping results in 19 pediatric‐epilepsy patients and compare those to defi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51594 |
| _version_ | 1798003083084562432 |
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| author | Alisa Pasichnik Melissa Tsuboyama Ali Jannati Clemente Vega Harper L. Kaye Ugur Damar Jeffrey Bolton Scellig S. D. Stone Joseph R. Madsen Ralph O. Suarez Alexander Rotenberg |
| author_facet | Alisa Pasichnik Melissa Tsuboyama Ali Jannati Clemente Vega Harper L. Kaye Ugur Damar Jeffrey Bolton Scellig S. D. Stone Joseph R. Madsen Ralph O. Suarez Alexander Rotenberg |
| author_sort | Alisa Pasichnik |
| collection | DOAJ |
| description | Abstract Neuronavigated transcranial magnetic stimulation (nTMS) has emerged as a presurgical language mapping tool distinct from the widely used functional magnetic resonance imaging (fMRI). We report fMRI and nTMS language‐mapping results in 19 pediatric‐epilepsy patients and compare those to definitive testing by electrical cortical stimulation, Wada test, and/or neuropsychological testing. Most discordant results occurred when fMRI found right‐hemispheric language. In those cases, when nTMS showed left‐hemispheric or bilateral language representation, left‐hemispheric language was confirmed by definitive testing. Therefore, we propose nTMS should be considered for pediatric presurgical language‐mapping when fMRI shows right‐hemispheric language, with nTMS results superseding fMRI results in those scenarios. |
| first_indexed | 2024-04-11T12:03:25Z |
| format | Article |
| id | doaj.art-d6ab589dadb249dfab51cabcab1813f4 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-04-11T12:03:25Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-d6ab589dadb249dfab51cabcab1813f42022-12-22T04:24:48ZengWileyAnnals of Clinical and Translational Neurology2328-95032022-09-01991459146410.1002/acn3.51594Discrepant expressive language lateralization in children and adolescents with epilepsyAlisa Pasichnik0Melissa Tsuboyama1Ali Jannati2Clemente Vega3Harper L. Kaye4Ugur Damar5Jeffrey Bolton6Scellig S. D. Stone7Joseph R. Madsen8Ralph O. Suarez9Alexander Rotenberg10Neuromodulation Program and Division of Epilepsy and Clinical Neurophysiology, Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USANeuromodulation Program and Division of Epilepsy and Clinical Neurophysiology, Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USANeuromodulation Program and Division of Epilepsy and Clinical Neurophysiology, Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USANeuromodulation Program and Division of Epilepsy and Clinical Neurophysiology, Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USANeuromodulation Program and Division of Epilepsy and Clinical Neurophysiology, Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USANeuromodulation Program and Division of Epilepsy and Clinical Neurophysiology, Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USANeuromodulation Program and Division of Epilepsy and Clinical Neurophysiology, Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USADepartment of Neurosurgery Boston Children's Hospital, Harvard Medical School Boston Massachusetts USADepartment of Neurosurgery Boston Children's Hospital, Harvard Medical School Boston Massachusetts USADepartment of Radiology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USANeuromodulation Program and Division of Epilepsy and Clinical Neurophysiology, Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USAAbstract Neuronavigated transcranial magnetic stimulation (nTMS) has emerged as a presurgical language mapping tool distinct from the widely used functional magnetic resonance imaging (fMRI). We report fMRI and nTMS language‐mapping results in 19 pediatric‐epilepsy patients and compare those to definitive testing by electrical cortical stimulation, Wada test, and/or neuropsychological testing. Most discordant results occurred when fMRI found right‐hemispheric language. In those cases, when nTMS showed left‐hemispheric or bilateral language representation, left‐hemispheric language was confirmed by definitive testing. Therefore, we propose nTMS should be considered for pediatric presurgical language‐mapping when fMRI shows right‐hemispheric language, with nTMS results superseding fMRI results in those scenarios.https://doi.org/10.1002/acn3.51594 |
| spellingShingle | Alisa Pasichnik Melissa Tsuboyama Ali Jannati Clemente Vega Harper L. Kaye Ugur Damar Jeffrey Bolton Scellig S. D. Stone Joseph R. Madsen Ralph O. Suarez Alexander Rotenberg Discrepant expressive language lateralization in children and adolescents with epilepsy Annals of Clinical and Translational Neurology |
| title | Discrepant expressive language lateralization in children and adolescents with epilepsy |
| title_full | Discrepant expressive language lateralization in children and adolescents with epilepsy |
| title_fullStr | Discrepant expressive language lateralization in children and adolescents with epilepsy |
| title_full_unstemmed | Discrepant expressive language lateralization in children and adolescents with epilepsy |
| title_short | Discrepant expressive language lateralization in children and adolescents with epilepsy |
| title_sort | discrepant expressive language lateralization in children and adolescents with epilepsy |
| url | https://doi.org/10.1002/acn3.51594 |
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