Anti-Tumor Effects of a Penetratin Peptide Targeting Transcription of E2F-1, 2 and 3a Is Enhanced When Used in Combination with Pemetrexed or Cisplatin

Anti-Tumor Effects of a Penetratin Peptide Targeting Transcription of E2F-1, 2 and 3a Is Enhanced When Used in Combination with Pemetrexed or Cisplatin

Background: We tested the antitumor effects of a modified E2F peptide substituting D-Arg for L-Arg, conjugated to penetratin (PEP) against solid tumor cell lines and the CCRF-leukemia cell line, alone and in combination with pemetrexed or with cisplatin. For <i>in</i>-<i>vivo</i...

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Bibliographic Details
Main Authors: Gulam Mohmad Rather, Michael Anyanwu, Tamara Minko, Olga Garbuzenko, Zoltan Szekely, Joseph R. Bertino
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
E2F
cisplatin
pemetrexed
thymidylate synthase
thymidine kinase
NSCLC
Online Access:https://www.mdpi.com/2072-6694/13/5/972

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