Role of Fucosylation in Cancer
Fucosylation is one of the most important glycosylation in mamal, involving biosynthesis of blood H antigen and Lewis antigen, selectin mediated intravasion and homing of leukocyte, host-microbe interactions, modification of signaling. Alterations in the expression of fucosylated oligosaccharides ha...
| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2016-11-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.11.07 |
| _version_ | 1828281306422706176 |
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| author | Kun ZHANG Hong WANG |
| author_facet | Kun ZHANG Hong WANG |
| author_sort | Kun ZHANG |
| collection | DOAJ |
| description | Fucosylation is one of the most important glycosylation in mamal, involving biosynthesis of blood H antigen and Lewis antigen, selectin mediated intravasion and homing of leukocyte, host-microbe interactions, modification of signaling. Alterations in the expression of fucosylated oligosaccharides have been observed in several cancer, playing a role in proliferation, invasion, metastasis, immune escape and drug-sensitiity, especially in lung cancer. Targeting the abnormality of fucosylaion in cancer will become a new strategy. The role of fucosylation in cancer will be reviewed in this article. |
| first_indexed | 2024-04-13T08:14:02Z |
| format | Article |
| id | doaj.art-d6abe094756a44dbb463da78c4c7e639 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-04-13T08:14:02Z |
| publishDate | 2016-11-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-d6abe094756a44dbb463da78c4c7e6392022-12-22T02:54:52ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872016-11-01191176076510.3779/j.issn.1009-3419.2016.11.07Role of Fucosylation in CancerKun ZHANG0Hong WANG1Department of Lung Oncology, Affiliated Hospital of the PLA Military Academy of Medical Sciences, Beijing 100071, ChinaDepartment of Lung Oncology, Affiliated Hospital of the PLA Military Academy of Medical Sciences, Beijing 100071, ChinaFucosylation is one of the most important glycosylation in mamal, involving biosynthesis of blood H antigen and Lewis antigen, selectin mediated intravasion and homing of leukocyte, host-microbe interactions, modification of signaling. Alterations in the expression of fucosylated oligosaccharides have been observed in several cancer, playing a role in proliferation, invasion, metastasis, immune escape and drug-sensitiity, especially in lung cancer. Targeting the abnormality of fucosylaion in cancer will become a new strategy. The role of fucosylation in cancer will be reviewed in this article.http://dx.doi.org/10.3779/j.issn.1009-3419.2016.11.07FucosylationNeoplasmsTherapy |
| spellingShingle | Kun ZHANG Hong WANG Role of Fucosylation in Cancer Chinese Journal of Lung Cancer Fucosylation Neoplasms Therapy |
| title | Role of Fucosylation in Cancer |
| title_full | Role of Fucosylation in Cancer |
| title_fullStr | Role of Fucosylation in Cancer |
| title_full_unstemmed | Role of Fucosylation in Cancer |
| title_short | Role of Fucosylation in Cancer |
| title_sort | role of fucosylation in cancer |
| topic | Fucosylation Neoplasms Therapy |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.11.07 |
| work_keys_str_mv | AT kunzhang roleoffucosylationincancer AT hongwang roleoffucosylationincancer |