RETRACTED – Influence of antidepressants on plasma levels of nitric oxide metabolites in patients with major depressive disorder
The impairment of endothelial function by reduced endothelial production of nitric oxide (NO) may contribute to the increased risk of developing cardiovascular disease in patients with depression. NO also plays an essential role in the efficacy of antidepressants. The present study aimed to confirm...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-01-01
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| Series: | BJPsych Open |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472421010747/type/journal_article |
| _version_ | 1811156969449324544 |
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| author | Atsuko Ikenouchi Naomichi Okamoto Yusuke Konno Rintaro Fujii Yoshihisa Fujino Reiji Yoshimura |
| author_facet | Atsuko Ikenouchi Naomichi Okamoto Yusuke Konno Rintaro Fujii Yoshihisa Fujino Reiji Yoshimura |
| author_sort | Atsuko Ikenouchi |
| collection | DOAJ |
| description | The impairment of endothelial function by reduced endothelial production of nitric oxide (NO) may contribute to the increased risk of developing cardiovascular disease in patients with depression. NO also plays an essential role in the efficacy of antidepressants. The present study aimed to confirm our previous preliminary findings using a larger sample and different antidepressants. We enrolled 100 patients with major depressive disorder (MDD) and 50 healthy controls. Patients were administered sertraline, duloxetine or mirtazapine and were followed up for 8 weeks. We also compared the rate of increase in plasma levels of metabolites of NO (NOx) among the three antidepressant treatments. Baseline plasma NOx levels were significantly lower in the MDD group than in the control group. A negative correlation was found between plasma NOx levels and the severity of MDD. Treatment with duloxetine significantly increased plasma NOx levels, whereas sertraline treatment caused no significant increase. |
| first_indexed | 2024-04-10T04:58:30Z |
| format | Article |
| id | doaj.art-d6ac149e741345538c170bdd50098c50 |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T04:58:30Z |
| publishDate | 2022-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-d6ac149e741345538c170bdd50098c502023-03-09T12:29:18ZengCambridge University PressBJPsych Open2056-47242022-01-01810.1192/bjo.2021.1074RETRACTED – Influence of antidepressants on plasma levels of nitric oxide metabolites in patients with major depressive disorderAtsuko Ikenouchi0https://orcid.org/0000-0001-8328-4608Naomichi Okamoto1Yusuke Konno2Rintaro Fujii3Yoshihisa Fujino4Reiji Yoshimura5Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Japan; and Medical Center for Dementia, University Hospital, University of Occupational and Environmental Health, JapanDepartment of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Japan; and Medical Center for Dementia, University Hospital, University of Occupational and Environmental Health, JapanDepartment of Psychiatry, School of Medicine, University of Occupational and Environmental Health, JapanDepartment of Psychiatry, School of Medicine, University of Occupational and Environmental Health, JapanDepartment of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, JapanDepartment of Psychiatry, School of Medicine, University of Occupational and Environmental Health, JapanThe impairment of endothelial function by reduced endothelial production of nitric oxide (NO) may contribute to the increased risk of developing cardiovascular disease in patients with depression. NO also plays an essential role in the efficacy of antidepressants. The present study aimed to confirm our previous preliminary findings using a larger sample and different antidepressants. We enrolled 100 patients with major depressive disorder (MDD) and 50 healthy controls. Patients were administered sertraline, duloxetine or mirtazapine and were followed up for 8 weeks. We also compared the rate of increase in plasma levels of metabolites of NO (NOx) among the three antidepressant treatments. Baseline plasma NOx levels were significantly lower in the MDD group than in the control group. A negative correlation was found between plasma NOx levels and the severity of MDD. Treatment with duloxetine significantly increased plasma NOx levels, whereas sertraline treatment caused no significant increase.https://www.cambridge.org/core/product/identifier/S2056472421010747/type/journal_articleDepressionnitric oxideantidepressantsnorepinephrinecardiovascular disease |
| spellingShingle | Atsuko Ikenouchi Naomichi Okamoto Yusuke Konno Rintaro Fujii Yoshihisa Fujino Reiji Yoshimura RETRACTED – Influence of antidepressants on plasma levels of nitric oxide metabolites in patients with major depressive disorder BJPsych Open Depression nitric oxide antidepressants norepinephrine cardiovascular disease |
| title | RETRACTED – Influence of antidepressants on plasma levels of nitric oxide metabolites in patients with major depressive disorder |
| title_full | RETRACTED – Influence of antidepressants on plasma levels of nitric oxide metabolites in patients with major depressive disorder |
| title_fullStr | RETRACTED – Influence of antidepressants on plasma levels of nitric oxide metabolites in patients with major depressive disorder |
| title_full_unstemmed | RETRACTED – Influence of antidepressants on plasma levels of nitric oxide metabolites in patients with major depressive disorder |
| title_short | RETRACTED – Influence of antidepressants on plasma levels of nitric oxide metabolites in patients with major depressive disorder |
| title_sort | retracted influence of antidepressants on plasma levels of nitric oxide metabolites in patients with major depressive disorder |
| topic | Depression nitric oxide antidepressants norepinephrine cardiovascular disease |
| url | https://www.cambridge.org/core/product/identifier/S2056472421010747/type/journal_article |
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