Temozolomide-associated blepharoconjunctivitis: a case report
Abstract Background Temozolomide (TMZ) is an effective oral alkylating agent used in treating glioblastoma multiforme (GBM) and high-grade gliomas. It works by introducing methyl groups into DNA, inhibiting cell division. A case of blepharoconjunctivitis linked to the administration of TMZ is detail...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-024-03417-6 |
| _version_ | 1797209507091185664 |
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| author | Tom Kornhauser John D Pemberton |
| author_facet | Tom Kornhauser John D Pemberton |
| author_sort | Tom Kornhauser |
| collection | DOAJ |
| description | Abstract Background Temozolomide (TMZ) is an effective oral alkylating agent used in treating glioblastoma multiforme (GBM) and high-grade gliomas. It works by introducing methyl groups into DNA, inhibiting cell division. A case of blepharoconjunctivitis linked to the administration of TMZ is detailed in this report. Case presentation We present a case of a 58-year-old African-American man diagnosed with GBM. Following adjuvant TMZ treatment, he developed blepharoconjunctivitis, characterized by eyelid and conjunctival inflammation. Symptoms included eyelid swelling, crusting, and conjunctival discharge, which were promptly resolved with topical steroid cream and eye drops. Conclusions Reports specifically linking TMZ to blepharoconjunctivitis are limited. The exact mechanism remains unclear but may involve inflammation extending from blepharitis to the conjunctiva. Healthcare providers must recognize and manage ophthalmic complications promptly. This case report highlights blepharoconjunctivitis associated with TMZ use in a GBM patient. While TMZ is an effective treatment, ophthalmic side effects can occur. |
| first_indexed | 2024-04-24T09:55:48Z |
| format | Article |
| id | doaj.art-d6ae0f8af0e84aae8ffe5785d5e35404 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-24T09:55:48Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-d6ae0f8af0e84aae8ffe5785d5e354042024-04-14T11:10:32ZengBMCBMC Ophthalmology1471-24152024-04-012411510.1186/s12886-024-03417-6Temozolomide-associated blepharoconjunctivitis: a case reportTom Kornhauser0John D Pemberton1Jones Eye Institute, University of Arkansas for Medical SciencesJones Eye Institute, University of Arkansas for Medical SciencesAbstract Background Temozolomide (TMZ) is an effective oral alkylating agent used in treating glioblastoma multiforme (GBM) and high-grade gliomas. It works by introducing methyl groups into DNA, inhibiting cell division. A case of blepharoconjunctivitis linked to the administration of TMZ is detailed in this report. Case presentation We present a case of a 58-year-old African-American man diagnosed with GBM. Following adjuvant TMZ treatment, he developed blepharoconjunctivitis, characterized by eyelid and conjunctival inflammation. Symptoms included eyelid swelling, crusting, and conjunctival discharge, which were promptly resolved with topical steroid cream and eye drops. Conclusions Reports specifically linking TMZ to blepharoconjunctivitis are limited. The exact mechanism remains unclear but may involve inflammation extending from blepharitis to the conjunctiva. Healthcare providers must recognize and manage ophthalmic complications promptly. This case report highlights blepharoconjunctivitis associated with TMZ use in a GBM patient. While TMZ is an effective treatment, ophthalmic side effects can occur.https://doi.org/10.1186/s12886-024-03417-6TemozolomideGlioblastoma multiformeBlepharoconjunctivitisBlepharitisCase report |
| spellingShingle | Tom Kornhauser John D Pemberton Temozolomide-associated blepharoconjunctivitis: a case report BMC Ophthalmology Temozolomide Glioblastoma multiforme Blepharoconjunctivitis Blepharitis Case report |
| title | Temozolomide-associated blepharoconjunctivitis: a case report |
| title_full | Temozolomide-associated blepharoconjunctivitis: a case report |
| title_fullStr | Temozolomide-associated blepharoconjunctivitis: a case report |
| title_full_unstemmed | Temozolomide-associated blepharoconjunctivitis: a case report |
| title_short | Temozolomide-associated blepharoconjunctivitis: a case report |
| title_sort | temozolomide associated blepharoconjunctivitis a case report |
| topic | Temozolomide Glioblastoma multiforme Blepharoconjunctivitis Blepharitis Case report |
| url | https://doi.org/10.1186/s12886-024-03417-6 |
| work_keys_str_mv | AT tomkornhauser temozolomideassociatedblepharoconjunctivitisacasereport AT johndpemberton temozolomideassociatedblepharoconjunctivitisacasereport |