Cognitive impairment in patients with Neuro‐Sjögren
Abstract Objective Extraglandular neurological manifestations of Sjögren’s syndrome are increasingly recognized, defining the disease entity of Neuro‐Sjögren. Neuropsychological assessment of patients with Sjögren’s syndrome has hitherto been performed on predominantly rheumatological cohorts. These...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-08-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51123 |
| _version_ | 1818652739207430144 |
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| author | Tabea Seeliger Lena Jacobsen Merle Hendel Lena Bönig Nils K. Kristian Prenzler Thea Thiele Diana Ernst Torsten Witte Martin Stangel Bruno Kopp Thomas Skripuletz |
| author_facet | Tabea Seeliger Lena Jacobsen Merle Hendel Lena Bönig Nils K. Kristian Prenzler Thea Thiele Diana Ernst Torsten Witte Martin Stangel Bruno Kopp Thomas Skripuletz |
| author_sort | Tabea Seeliger |
| collection | DOAJ |
| description | Abstract Objective Extraglandular neurological manifestations of Sjögren’s syndrome are increasingly recognized, defining the disease entity of Neuro‐Sjögren. Neuropsychological assessment of patients with Sjögren’s syndrome has hitherto been performed on predominantly rheumatological cohorts. These studies revealed a wide variety of prevalence rates for cognitive impairment (22–80%), while variable cut‐off criteria for detection of cognitive impairment were applied. Attentional functions have not yet been thoroughly investigated in these patients, although they clearly represent relevant aspects of cognitive functioning in daily life. Methods We therefore conducted extensive neuropsychological assessment based on two neuropsychological test batteries [i.e., the extended German version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD‐PLUS), and the test battery for attentional performance (TAP) as a well‐established assessment of attentional functions in the German‐speaking part of Europe]. Results Sixty‐four patients with Neuro‐Sjögren, who were treated at our university hospital between December 2016 and January 2019, were included. Evidence for the presence of cognitive impairment was found in 55% of patients with Neuro‐Sjögren. The degree of cognitive impairment ranged from mild (38%) to severe (17%). Attentional and mnemonic subtests showed pronounced cognitive impairment in patients with Neuro‐Sjögren. Interpretation Our results suggest that a substantial proportion of patients with Neuro‐Sjögren suffer from cognitive impairment, putatively as a corollary of attentional deficits, which might exert adverse effects on occupational abilities, other cognitive functions, and social role functioning. |
| first_indexed | 2024-12-17T02:26:47Z |
| format | Article |
| id | doaj.art-d6ae2088bde446dca5cb18ca3fb937ba |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-17T02:26:47Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-d6ae2088bde446dca5cb18ca3fb937ba2022-12-21T22:07:05ZengWileyAnnals of Clinical and Translational Neurology2328-95032020-08-01781352135910.1002/acn3.51123Cognitive impairment in patients with Neuro‐SjögrenTabea Seeliger0Lena Jacobsen1Merle Hendel2Lena Bönig3Nils K. Kristian Prenzler4Thea Thiele5Diana Ernst6Torsten Witte7Martin Stangel8Bruno Kopp9Thomas Skripuletz10Department of Neurology Hanover Medical School Hanover GermanyDepartment of Neurology Hanover Medical School Hanover GermanyDepartment of Neurology Hanover Medical School Hanover GermanyDepartment of Neurology Hanover Medical School Hanover GermanyDepartment of Otolaryngology Hanover Medical School Hanover GermanyDepartment of Clinical Immunology and Rheumatology Hanover Medical School Hanover GermanyDepartment of Clinical Immunology and Rheumatology Hanover Medical School Hanover GermanyDepartment of Clinical Immunology and Rheumatology Hanover Medical School Hanover GermanyDepartment of Neurology Hanover Medical School Hanover GermanyDepartment of Neurology Hanover Medical School Hanover GermanyDepartment of Neurology Hanover Medical School Hanover GermanyAbstract Objective Extraglandular neurological manifestations of Sjögren’s syndrome are increasingly recognized, defining the disease entity of Neuro‐Sjögren. Neuropsychological assessment of patients with Sjögren’s syndrome has hitherto been performed on predominantly rheumatological cohorts. These studies revealed a wide variety of prevalence rates for cognitive impairment (22–80%), while variable cut‐off criteria for detection of cognitive impairment were applied. Attentional functions have not yet been thoroughly investigated in these patients, although they clearly represent relevant aspects of cognitive functioning in daily life. Methods We therefore conducted extensive neuropsychological assessment based on two neuropsychological test batteries [i.e., the extended German version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD‐PLUS), and the test battery for attentional performance (TAP) as a well‐established assessment of attentional functions in the German‐speaking part of Europe]. Results Sixty‐four patients with Neuro‐Sjögren, who were treated at our university hospital between December 2016 and January 2019, were included. Evidence for the presence of cognitive impairment was found in 55% of patients with Neuro‐Sjögren. The degree of cognitive impairment ranged from mild (38%) to severe (17%). Attentional and mnemonic subtests showed pronounced cognitive impairment in patients with Neuro‐Sjögren. Interpretation Our results suggest that a substantial proportion of patients with Neuro‐Sjögren suffer from cognitive impairment, putatively as a corollary of attentional deficits, which might exert adverse effects on occupational abilities, other cognitive functions, and social role functioning.https://doi.org/10.1002/acn3.51123 |
| spellingShingle | Tabea Seeliger Lena Jacobsen Merle Hendel Lena Bönig Nils K. Kristian Prenzler Thea Thiele Diana Ernst Torsten Witte Martin Stangel Bruno Kopp Thomas Skripuletz Cognitive impairment in patients with Neuro‐Sjögren Annals of Clinical and Translational Neurology |
| title | Cognitive impairment in patients with Neuro‐Sjögren |
| title_full | Cognitive impairment in patients with Neuro‐Sjögren |
| title_fullStr | Cognitive impairment in patients with Neuro‐Sjögren |
| title_full_unstemmed | Cognitive impairment in patients with Neuro‐Sjögren |
| title_short | Cognitive impairment in patients with Neuro‐Sjögren |
| title_sort | cognitive impairment in patients with neuro sjogren |
| url | https://doi.org/10.1002/acn3.51123 |
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