Associations of Elderly Onset Headache With Occurrence of Poor Functional Outcome, Cardiovascular Disease, and Cognitive Dysfunction During Long-term Follow-up
Background: Although the frequency and intensity of headaches decrease in older adults, headaches in this population are still an important neurological disorder. The purpose of this study was to investigate the associations of headache characteristics in older adults with the development of cardiov...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korea Geriatrics Society
2018-12-01
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| Series: | Annals of Geriatric Medicine and Research |
| Subjects: | |
| Online Access: | http://www.e-agmr.org/journal/view.html?doi=10.4235/agmr.18.0032 |
| _version_ | 1818175321277464576 |
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| author | Soo-Jin Cho Byung-Kun Kim Byung-Su Kim Jae-Moon Kim Soo-Kyoung Kim Heui-Soo Moon Myoung-Jin Cha Kwang-Yeol Park Jong-Hee Sohn Min Kyung Chu Tae-Jin Song |
| author_facet | Soo-Jin Cho Byung-Kun Kim Byung-Su Kim Jae-Moon Kim Soo-Kyoung Kim Heui-Soo Moon Myoung-Jin Cha Kwang-Yeol Park Jong-Hee Sohn Min Kyung Chu Tae-Jin Song |
| author_sort | Soo-Jin Cho |
| collection | DOAJ |
| description | Background: Although the frequency and intensity of headaches decrease in older adults, headaches in this population are still an important neurological disorder. The purpose of this study was to investigate the associations of headache characteristics in older adults with the development of cardiovascular disease and cognitive dysfunction. Methods: We prospectively enrolled 125 older (≥ 65 years old) patients with headache who were making their first visit to outpatient clinics and who had no prior history of cognitive dysfunction from 11 hospitals in Korea between August 2014 and February 2015. We investigated the occurrence of newly developed/or recurrent headache, cardiovascular disease, cognitive dysfunction, and poor functional outcomes. Results: The mean age of all included patients was 72.6 years, 68.8% were women, and 43 (34.4%) had newly developed/or recurrent headache during follow-up. During a median follow-up of 31 months (interquartile range, 28–34 months), 21 participants (16.8%) experienced cardiovascular disease, and 26 (20.8%) developed cognitive dysfunction. Upon multivariate analysis and after adjusting for sex, age, and other factors, presence of newly developed/or recurrent headache was found to be associated with cardiovascular disease (hazard ratio [HR], 4.03; 95% confidence interval [CI], 1.28–12.61; p=0.017) and frequency of headache for the recent 3 months was related with cognitive dysfunction (HR, 1.05; 95% CI, 1.00–1.09; p=0.017) and poor functional outcomes (HR, 1.06; 95% CI, 1.01–1.11; p=0.011). Conclusion: Our study demonstrated that there is an increased risk of cardiovascular disease, cognitive dysfunction, and poor functional outcomes in older patients with frequent, newly developed, or recurrent headache. |
| first_indexed | 2024-12-11T19:58:26Z |
| format | Article |
| id | doaj.art-d6aec7479f884a5c8cfb3e96b3091f86 |
| institution | Directory Open Access Journal |
| issn | 2508-4798 |
| language | English |
| last_indexed | 2024-12-11T19:58:26Z |
| publishDate | 2018-12-01 |
| publisher | Korea Geriatrics Society |
| record_format | Article |
| series | Annals of Geriatric Medicine and Research |
| spelling | doaj.art-d6aec7479f884a5c8cfb3e96b3091f862022-12-22T00:52:35ZengKorea Geriatrics SocietyAnnals of Geriatric Medicine and Research2508-47982018-12-0122417618310.4235/agmr.18.0032agmr.18.0032Associations of Elderly Onset Headache With Occurrence of Poor Functional Outcome, Cardiovascular Disease, and Cognitive Dysfunction During Long-term Follow-upSoo-Jin Cho0Byung-Kun Kim1Byung-Su Kim2Jae-Moon Kim3Soo-Kyoung Kim4Heui-Soo Moon5Myoung-Jin Cha6Kwang-Yeol Park7Jong-Hee Sohn8Min Kyung Chu9Tae-Jin Song10Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, KoreaDepartment of Neurology, Eulji University School of Medicine, Seoul, KoreaDepartment of Neurology, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, KoreaDepartment of Neurology, Chungnam National University College of Medicine, Daejeon, KoreaDepartment of Neurology, Gyeongsang National University Hospital, Jinju, KoreaDepartment of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Neurology, National Police Hospital, Seoul, KoreaDepartment of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, KoreaDepartment of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, KoreaDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaDepartment of Neurology, Ewha Womans University College of Medicine, Seoul, KoreaBackground: Although the frequency and intensity of headaches decrease in older adults, headaches in this population are still an important neurological disorder. The purpose of this study was to investigate the associations of headache characteristics in older adults with the development of cardiovascular disease and cognitive dysfunction. Methods: We prospectively enrolled 125 older (≥ 65 years old) patients with headache who were making their first visit to outpatient clinics and who had no prior history of cognitive dysfunction from 11 hospitals in Korea between August 2014 and February 2015. We investigated the occurrence of newly developed/or recurrent headache, cardiovascular disease, cognitive dysfunction, and poor functional outcomes. Results: The mean age of all included patients was 72.6 years, 68.8% were women, and 43 (34.4%) had newly developed/or recurrent headache during follow-up. During a median follow-up of 31 months (interquartile range, 28–34 months), 21 participants (16.8%) experienced cardiovascular disease, and 26 (20.8%) developed cognitive dysfunction. Upon multivariate analysis and after adjusting for sex, age, and other factors, presence of newly developed/or recurrent headache was found to be associated with cardiovascular disease (hazard ratio [HR], 4.03; 95% confidence interval [CI], 1.28–12.61; p=0.017) and frequency of headache for the recent 3 months was related with cognitive dysfunction (HR, 1.05; 95% CI, 1.00–1.09; p=0.017) and poor functional outcomes (HR, 1.06; 95% CI, 1.01–1.11; p=0.011). Conclusion: Our study demonstrated that there is an increased risk of cardiovascular disease, cognitive dysfunction, and poor functional outcomes in older patients with frequent, newly developed, or recurrent headache.http://www.e-agmr.org/journal/view.html?doi=10.4235/agmr.18.0032Migraine disordersTension-type headacheElderly headacheCardiovascular diseasesCognitive dysfunction |
| spellingShingle | Soo-Jin Cho Byung-Kun Kim Byung-Su Kim Jae-Moon Kim Soo-Kyoung Kim Heui-Soo Moon Myoung-Jin Cha Kwang-Yeol Park Jong-Hee Sohn Min Kyung Chu Tae-Jin Song Associations of Elderly Onset Headache With Occurrence of Poor Functional Outcome, Cardiovascular Disease, and Cognitive Dysfunction During Long-term Follow-up Annals of Geriatric Medicine and Research Migraine disorders Tension-type headache Elderly headache Cardiovascular diseases Cognitive dysfunction |
| title | Associations of Elderly Onset Headache With Occurrence of Poor Functional Outcome, Cardiovascular Disease, and Cognitive Dysfunction During Long-term Follow-up |
| title_full | Associations of Elderly Onset Headache With Occurrence of Poor Functional Outcome, Cardiovascular Disease, and Cognitive Dysfunction During Long-term Follow-up |
| title_fullStr | Associations of Elderly Onset Headache With Occurrence of Poor Functional Outcome, Cardiovascular Disease, and Cognitive Dysfunction During Long-term Follow-up |
| title_full_unstemmed | Associations of Elderly Onset Headache With Occurrence of Poor Functional Outcome, Cardiovascular Disease, and Cognitive Dysfunction During Long-term Follow-up |
| title_short | Associations of Elderly Onset Headache With Occurrence of Poor Functional Outcome, Cardiovascular Disease, and Cognitive Dysfunction During Long-term Follow-up |
| title_sort | associations of elderly onset headache with occurrence of poor functional outcome cardiovascular disease and cognitive dysfunction during long term follow up |
| topic | Migraine disorders Tension-type headache Elderly headache Cardiovascular diseases Cognitive dysfunction |
| url | http://www.e-agmr.org/journal/view.html?doi=10.4235/agmr.18.0032 |
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