Safety and efficacy of a feed additive consisting of endo‐1,3(4)‐beta‐glucanase produced by Aspergillus fijiensis CBS 589.94 (RONOZYME® VP (CT/L)) for chickens for fattening and weaned piglets (DSM Nutritional Products AG)
Abstract Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of endo‐1,3(4)‐beta‐glucanase produced by Aspergillus fijiensis CBS 589.94 (RONOZYME® VP...
| Những tác giả chính: | , , , , , , , , , , , , , , , , , , , , , |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
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Wiley
2023-01-01
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| Loạt: | EFSA Journal |
| Những chủ đề: | |
| Truy cập trực tuyến: | https://doi.org/10.2903/j.efsa.2023.7703 |
| _version_ | 1827913774042972160 |
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| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Mojca Fašmon Durjava Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Jaume Galobart Elisa Pettenati Jordi Ortuño Montserrat Anguita |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Mojca Fašmon Durjava Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Jaume Galobart Elisa Pettenati Jordi Ortuño Montserrat Anguita |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of endo‐1,3(4)‐beta‐glucanase produced by Aspergillus fijiensis CBS 589.94 (RONOZYME® VP (CT/L)) as a zootechnical feed additive for chickens for fattening and weaned piglets. Based on the no observed adverse effect level identified in a subchronic oral toxicity study in rats and the tolerance trials provided, the additive was considered safe for chickens for fattening and weaned piglets at the proposed conditions of use. The Panel also concluded that the use of the product as a feed additive does not rise concerns for consumers and the environment. Owing to the lack of data obtained with the final formulations, the Panel could not conclude on the potential of the additive to be irritant to skin and eyes or on its potential as a dermal sensitiser. Due to the proteinaceous nature of the active substance, the additive is considered a respiratory sensitiser. The Panel concluded that the additive is efficacious as a zootechnical additive in chickens for fattening and weaned piglets at the minimum recommended level of 10 FBG/kg feed. |
| first_indexed | 2024-03-13T02:35:43Z |
| format | Article |
| id | doaj.art-d6af274a1df549d59aeee6c97e14cc4e |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-03-13T02:35:43Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-d6af274a1df549d59aeee6c97e14cc4e2023-06-29T07:10:37ZengWileyEFSA Journal1831-47322023-01-01211n/an/a10.2903/j.efsa.2023.7703Safety and efficacy of a feed additive consisting of endo‐1,3(4)‐beta‐glucanase produced by Aspergillus fijiensis CBS 589.94 (RONOZYME® VP (CT/L)) for chickens for fattening and weaned piglets (DSM Nutritional Products AG)EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Vasileios BampidisGiovanna AzimontiMaria de Lourdes BastosHenrik ChristensenBirgit DusemundMojca Fašmon DurjavaMaryline KoubaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaFernando RamosYolanda SanzRoberto Edoardo VillaRuud WoutersenJaume GalobartElisa PettenatiJordi OrtuñoMontserrat AnguitaAbstract Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of endo‐1,3(4)‐beta‐glucanase produced by Aspergillus fijiensis CBS 589.94 (RONOZYME® VP (CT/L)) as a zootechnical feed additive for chickens for fattening and weaned piglets. Based on the no observed adverse effect level identified in a subchronic oral toxicity study in rats and the tolerance trials provided, the additive was considered safe for chickens for fattening and weaned piglets at the proposed conditions of use. The Panel also concluded that the use of the product as a feed additive does not rise concerns for consumers and the environment. Owing to the lack of data obtained with the final formulations, the Panel could not conclude on the potential of the additive to be irritant to skin and eyes or on its potential as a dermal sensitiser. Due to the proteinaceous nature of the active substance, the additive is considered a respiratory sensitiser. The Panel concluded that the additive is efficacious as a zootechnical additive in chickens for fattening and weaned piglets at the minimum recommended level of 10 FBG/kg feed.https://doi.org/10.2903/j.efsa.2023.7703zootechnical additivesdigestibility enhancerssafetyefficacyendo‐1,3(4)‐beta‐glucanasechickens for fattening |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Mojca Fašmon Durjava Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Jaume Galobart Elisa Pettenati Jordi Ortuño Montserrat Anguita Safety and efficacy of a feed additive consisting of endo‐1,3(4)‐beta‐glucanase produced by Aspergillus fijiensis CBS 589.94 (RONOZYME® VP (CT/L)) for chickens for fattening and weaned piglets (DSM Nutritional Products AG) EFSA Journal zootechnical additives digestibility enhancers safety efficacy endo‐1,3(4)‐beta‐glucanase chickens for fattening |
| title | Safety and efficacy of a feed additive consisting of endo‐1,3(4)‐beta‐glucanase produced by Aspergillus fijiensis CBS 589.94 (RONOZYME® VP (CT/L)) for chickens for fattening and weaned piglets (DSM Nutritional Products AG) |
| title_full | Safety and efficacy of a feed additive consisting of endo‐1,3(4)‐beta‐glucanase produced by Aspergillus fijiensis CBS 589.94 (RONOZYME® VP (CT/L)) for chickens for fattening and weaned piglets (DSM Nutritional Products AG) |
| title_fullStr | Safety and efficacy of a feed additive consisting of endo‐1,3(4)‐beta‐glucanase produced by Aspergillus fijiensis CBS 589.94 (RONOZYME® VP (CT/L)) for chickens for fattening and weaned piglets (DSM Nutritional Products AG) |
| title_full_unstemmed | Safety and efficacy of a feed additive consisting of endo‐1,3(4)‐beta‐glucanase produced by Aspergillus fijiensis CBS 589.94 (RONOZYME® VP (CT/L)) for chickens for fattening and weaned piglets (DSM Nutritional Products AG) |
| title_short | Safety and efficacy of a feed additive consisting of endo‐1,3(4)‐beta‐glucanase produced by Aspergillus fijiensis CBS 589.94 (RONOZYME® VP (CT/L)) for chickens for fattening and weaned piglets (DSM Nutritional Products AG) |
| title_sort | safety and efficacy of a feed additive consisting of endo 1 3 4 beta glucanase produced by aspergillus fijiensis cbs 589 94 ronozyme r vp ct l for chickens for fattening and weaned piglets dsm nutritional products ag |
| topic | zootechnical additives digestibility enhancers safety efficacy endo‐1,3(4)‐beta‐glucanase chickens for fattening |
| url | https://doi.org/10.2903/j.efsa.2023.7703 |
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