Efficacy of nutrition therapy with food rich in methionine for treating nonalcoholic fatty liver
Introduction. Non-Alcoholic Fatty Liver disease (NAFLD) can lead to Non Alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. The treatment for NAFLD involves modification of caloric intake and physical activity. NAFLD has a pro-oxidant nature; therefore, it is logical to suppose that the a...
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| Format: | Article |
| Language: | English |
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Sociedad Latinoamericana de Nutrición
2023-08-01
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| Series: | Archivos Latinoamericanos de Nutrición |
| Subjects: | |
| Online Access: | https://www.alanrevista.org/ediciones/2023/2/art-4/ |
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| author | Jaime Morales-Romero María Cristina Ortíz León Héctor Hernández-Gutierrez Roberto A. Bahena-Cerón Aidé Miranda-Reza José A. Marin-Carmona Edit Rodríguez-Romero Silvia I. Mora-Herrera Jonathan Garcia-Roman Julio I. Peréz-Carreón Eduardo Rivadeneyra-Domínguez Gabriel Riande-Juárez Rebeca Garcia-Roman |
| author_facet | Jaime Morales-Romero María Cristina Ortíz León Héctor Hernández-Gutierrez Roberto A. Bahena-Cerón Aidé Miranda-Reza José A. Marin-Carmona Edit Rodríguez-Romero Silvia I. Mora-Herrera Jonathan Garcia-Roman Julio I. Peréz-Carreón Eduardo Rivadeneyra-Domínguez Gabriel Riande-Juárez Rebeca Garcia-Roman |
| author_sort | Jaime Morales-Romero |
| collection | DOAJ |
| description | Introduction. Non-Alcoholic Fatty Liver disease (NAFLD) can lead to Non Alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. The treatment for NAFLD involves modification of caloric intake and physical activity. NAFLD has a pro-oxidant nature; therefore, it is logical to suppose that the antioxidant methionine can be used as a treatment for this disease. Aim. This study aimed to evaluate the effect of high-methionine dietary therapy on patients with NAFLD. Materials and methods. A randomized clinical study was conducted over three months. In this study, 121 NAFLD patients participated, and the age of the participants was ≥ 20 years (experimental group included 56 and control group 65), all of whom were randomized and matched by sex, recluted from the ISSSTE hospital in Xalapa, Mexico. The patients were instructed to consume food to cover the recommended methionine daily doses, and the daily amount consumed was calculated. Methionine effect was measured as NAFLD regression and quality of life improvement. Results. Nutritional therapy induced NAFLD regression and diminished central fat accumulation, blood pressure, and the fatty liver index. Some parameters, such as liver enzymes, did not changed. The quality of life of patients improved after treatment. Conclusions. In this study, we show a hepatoprotective effect induced only in three months of chances in the diet, thus, a longer diet may generate more relevant benefits in the resistant parameters of our study. |
| first_indexed | 2024-03-12T02:52:37Z |
| format | Article |
| id | doaj.art-d6af8926d3874c7f9a8d7a3db3ba6ff0 |
| institution | Directory Open Access Journal |
| issn | 0004-0622 2309-5806 |
| language | English |
| last_indexed | 2024-03-12T02:52:37Z |
| publishDate | 2023-08-01 |
| publisher | Sociedad Latinoamericana de Nutrición |
| record_format | Article |
| series | Archivos Latinoamericanos de Nutrición |
| spelling | doaj.art-d6af8926d3874c7f9a8d7a3db3ba6ff02023-09-03T15:46:25ZengSociedad Latinoamericana de NutriciónArchivos Latinoamericanos de Nutrición0004-06222309-58062023-08-0173212213410.37527/2023.73.2.004Efficacy of nutrition therapy with food rich in methionine for treating nonalcoholic fatty liverJaime Morales-Romero0https://orcid.org/0000-0002-1492-1797María Cristina Ortíz León1https://orcid.org/0000-0003-4953-5076Héctor Hernández-Gutierrez2https://orcid.org/0000-0001-9648-8714Roberto A. Bahena-Cerón3https://orcid.org/0000-0002-4220-121XAidé Miranda-Reza4José A. Marin-Carmona5https://orcid.org/0000-0001-8299-5387Edit Rodríguez-Romero6https://orcid.org/0000-0003-1653-4835Silvia I. Mora-Herrera7https://orcid.org/0000-0003-2564-5879Jonathan Garcia-Roman8https://orcid.org/0000-0002-8220-5135Julio I. Peréz-Carreón9https://orcid.org/0000-0001-9284-7775Eduardo Rivadeneyra-Domínguez10https://orcid.org/0000-0001-5662-2202Gabriel Riande-Juárez11Rebeca Garcia-Roman12https://orcid.org/0000-0002-6802-1188Institute of Public Health, Universidad VeracruzanaInstitute of Public Health, Universidad VeracruzanaISSSTE Hospital Clinic, Xalapa, VeracruzFaculty of Biological Pharmaceutical Chemistry, Universidad Veracruzana, Xalapa, VeracruzFaculty of Statistics and Informatics, Universidad Veracruzana, Xalapa, VeracruzFaculty of Biology, Universidad Veracruzana, Xalapa, VeracruzInstitute of Public Health, Universidad VeracruzanaMetabolomics and Proteomics Unit. Institute of Biomedical Research UNAM, México CityFaculty of Medicine Poza Rica-Tuxpan Region, Universidad Veracruzana, Poza Rica, VeracruzLaboratory of Hepatic Diseases, National Institute of Genomic Medicine (INMEGEN), Mexico CityFaculty of Biological Pharmaceutical Chemistry, Universidad Veracruzana, Xalapa, VeracruzInstitute of Public Health, Universidad VeracruzanaInstitute of Public Health, Universidad VeracruzanaIntroduction. Non-Alcoholic Fatty Liver disease (NAFLD) can lead to Non Alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. The treatment for NAFLD involves modification of caloric intake and physical activity. NAFLD has a pro-oxidant nature; therefore, it is logical to suppose that the antioxidant methionine can be used as a treatment for this disease. Aim. This study aimed to evaluate the effect of high-methionine dietary therapy on patients with NAFLD. Materials and methods. A randomized clinical study was conducted over three months. In this study, 121 NAFLD patients participated, and the age of the participants was ≥ 20 years (experimental group included 56 and control group 65), all of whom were randomized and matched by sex, recluted from the ISSSTE hospital in Xalapa, Mexico. The patients were instructed to consume food to cover the recommended methionine daily doses, and the daily amount consumed was calculated. Methionine effect was measured as NAFLD regression and quality of life improvement. Results. Nutritional therapy induced NAFLD regression and diminished central fat accumulation, blood pressure, and the fatty liver index. Some parameters, such as liver enzymes, did not changed. The quality of life of patients improved after treatment. Conclusions. In this study, we show a hepatoprotective effect induced only in three months of chances in the diet, thus, a longer diet may generate more relevant benefits in the resistant parameters of our study.https://www.alanrevista.org/ediciones/2023/2/art-4/methioninenafld reversaland nutrition therapy |
| spellingShingle | Jaime Morales-Romero María Cristina Ortíz León Héctor Hernández-Gutierrez Roberto A. Bahena-Cerón Aidé Miranda-Reza José A. Marin-Carmona Edit Rodríguez-Romero Silvia I. Mora-Herrera Jonathan Garcia-Roman Julio I. Peréz-Carreón Eduardo Rivadeneyra-Domínguez Gabriel Riande-Juárez Rebeca Garcia-Roman Efficacy of nutrition therapy with food rich in methionine for treating nonalcoholic fatty liver Archivos Latinoamericanos de Nutrición methionine nafld reversal and nutrition therapy |
| title | Efficacy of nutrition therapy with food rich in methionine for treating nonalcoholic fatty liver |
| title_full | Efficacy of nutrition therapy with food rich in methionine for treating nonalcoholic fatty liver |
| title_fullStr | Efficacy of nutrition therapy with food rich in methionine for treating nonalcoholic fatty liver |
| title_full_unstemmed | Efficacy of nutrition therapy with food rich in methionine for treating nonalcoholic fatty liver |
| title_short | Efficacy of nutrition therapy with food rich in methionine for treating nonalcoholic fatty liver |
| title_sort | efficacy of nutrition therapy with food rich in methionine for treating nonalcoholic fatty liver |
| topic | methionine nafld reversal and nutrition therapy |
| url | https://www.alanrevista.org/ediciones/2023/2/art-4/ |
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