Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases
Abstract Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved in osteoclast differentiation, and is considered to be a potential therapeutic target for osteoporosis. Recent studies reveale...
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | Journal of Biomedical Science |
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| Online Access: | https://doi.org/10.1186/s12929-019-0610-1 |
| _version_ | 1818364037798297600 |
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| author | Takashi Angata |
| author_facet | Takashi Angata |
| author_sort | Takashi Angata |
| collection | DOAJ |
| description | Abstract Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved in osteoclast differentiation, and is considered to be a potential therapeutic target for osteoporosis. Recent studies revealed unexpected roles of Siglec-15 in microbial infection and the cancer microenvironment, expanding the potential pathophysiological roles of Siglec-15. Chemical biology has advanced our understanding of the nature of Siglec-15 ligands, but the exact nature of Siglec-15 ligand depends on the biological context, leaving plenty of room for further exploration. |
| first_indexed | 2024-12-13T21:58:00Z |
| format | Article |
| id | doaj.art-d6b06b7bc7814f61824ec955fb1f00f1 |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-12-13T21:58:00Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-d6b06b7bc7814f61824ec955fb1f00f12022-12-21T23:30:05ZengBMCJournal of Biomedical Science1423-01272020-01-012711710.1186/s12929-019-0610-1Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseasesTakashi Angata0Institute of Biological Chemistry, Academia SinicaAbstract Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved in osteoclast differentiation, and is considered to be a potential therapeutic target for osteoporosis. Recent studies revealed unexpected roles of Siglec-15 in microbial infection and the cancer microenvironment, expanding the potential pathophysiological roles of Siglec-15. Chemical biology has advanced our understanding of the nature of Siglec-15 ligands, but the exact nature of Siglec-15 ligand depends on the biological context, leaving plenty of room for further exploration.https://doi.org/10.1186/s12929-019-0610-1Siglec-15Sialic acidOsteoclastMacrophageCancerMicrobial infection |
| spellingShingle | Takashi Angata Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases Journal of Biomedical Science Siglec-15 Sialic acid Osteoclast Macrophage Cancer Microbial infection |
| title | Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases |
| title_full | Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases |
| title_fullStr | Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases |
| title_full_unstemmed | Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases |
| title_short | Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases |
| title_sort | siglec 15 a potential regulator of osteoporosis cancer and infectious diseases |
| topic | Siglec-15 Sialic acid Osteoclast Macrophage Cancer Microbial infection |
| url | https://doi.org/10.1186/s12929-019-0610-1 |
| work_keys_str_mv | AT takashiangata siglec15apotentialregulatorofosteoporosiscancerandinfectiousdiseases |