Depression and risk of sarcopenia: a national cohort and Mendelian randomization study
BackgroundDepression and the increased risk of sarcopenia are prevalent among the elderly population. However, the causal associations between these factors remain unclear. To investigate the potential association between depression and the risk of sarcopenia in older adults, this study was performe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1263553/full |
| _version_ | 1797657491163578368 |
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| author | Qian Zhong Lisha Jiang Kang An Lin Zhang Shuangqing Li Zhenmei An |
| author_facet | Qian Zhong Lisha Jiang Kang An Lin Zhang Shuangqing Li Zhenmei An |
| author_sort | Qian Zhong |
| collection | DOAJ |
| description | BackgroundDepression and the increased risk of sarcopenia are prevalent among the elderly population. However, the causal associations between these factors remain unclear. To investigate the potential association between depression and the risk of sarcopenia in older adults, this study was performed.MethodsIn the baseline survey, a total of 14,258 individuals aged 40 and above from the China Health and Retirement Longitudinal Study (2015) participated. We initially described the baseline prevalence of the disease. Then, logistic regression and restricted cubic spline (RCS) regression were conducted to assess the relationship between depression and sarcopenia. Subgroup analysis was performed to validate the robustness of the findings. Additionally, we conducted Mendelian randomization analysis using the inverse variance weighting estimator to assess the causal relationship between depression and sarcopenia. Furthermore, we adopted six methods, including MR-Egger, simple median, weighted median, maximum likelihood, robust adjusted profile score (RAPS), and MR Pleiotropy Residual Sum and Outlier (MR-PRESSO), for sensitivity analyses.ResultsDepression patients exhibited higher risks of sarcopenia in all five models adjusting for different covariates (P < 0.05). The RCS analysis demonstrated a linear relationship between depression and sarcopenia (P < 0.05). In the subgroup analysis, increased risk was observed among participants aged 60−70, married or cohabiting individuals, non-smokers, non-drinkers, those with less than 8 h of sleep, BMI below 24, and individuals with hypertension (all P < 0.05). Mendelian randomization results revealed that genetically proxied depression led to a reduction in appendicular skeletal muscle mass (all P < 0.05).ConclusionOur study provides observational and causal evidences that depression can lead to sarcopenia. This finding emphasizes the importance of timely identification and management of depression, as well as implementing targeted educational programs as part of comprehensive strategies to prevent sarcopenia. |
| first_indexed | 2024-03-11T17:45:15Z |
| format | Article |
| id | doaj.art-d6b0af20d9364c36a64f77352a2373be |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-11T17:45:15Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-d6b0af20d9364c36a64f77352a2373be2023-10-18T08:01:10ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-10-011410.3389/fpsyt.2023.12635531263553Depression and risk of sarcopenia: a national cohort and Mendelian randomization studyQian Zhong0Lisha Jiang1Kang An2Lin Zhang3Shuangqing Li4Zhenmei An5Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDay Surgery Center of West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, National Clinical Research Center for Geriatrics, Multimorbidity Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, National Clinical Research Center for Geriatrics, Multimorbidity Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, National Clinical Research Center for Geriatrics, Multimorbidity Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaBackgroundDepression and the increased risk of sarcopenia are prevalent among the elderly population. However, the causal associations between these factors remain unclear. To investigate the potential association between depression and the risk of sarcopenia in older adults, this study was performed.MethodsIn the baseline survey, a total of 14,258 individuals aged 40 and above from the China Health and Retirement Longitudinal Study (2015) participated. We initially described the baseline prevalence of the disease. Then, logistic regression and restricted cubic spline (RCS) regression were conducted to assess the relationship between depression and sarcopenia. Subgroup analysis was performed to validate the robustness of the findings. Additionally, we conducted Mendelian randomization analysis using the inverse variance weighting estimator to assess the causal relationship between depression and sarcopenia. Furthermore, we adopted six methods, including MR-Egger, simple median, weighted median, maximum likelihood, robust adjusted profile score (RAPS), and MR Pleiotropy Residual Sum and Outlier (MR-PRESSO), for sensitivity analyses.ResultsDepression patients exhibited higher risks of sarcopenia in all five models adjusting for different covariates (P < 0.05). The RCS analysis demonstrated a linear relationship between depression and sarcopenia (P < 0.05). In the subgroup analysis, increased risk was observed among participants aged 60−70, married or cohabiting individuals, non-smokers, non-drinkers, those with less than 8 h of sleep, BMI below 24, and individuals with hypertension (all P < 0.05). Mendelian randomization results revealed that genetically proxied depression led to a reduction in appendicular skeletal muscle mass (all P < 0.05).ConclusionOur study provides observational and causal evidences that depression can lead to sarcopenia. This finding emphasizes the importance of timely identification and management of depression, as well as implementing targeted educational programs as part of comprehensive strategies to prevent sarcopenia.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1263553/fullsarcopeniadepressionlow muscle massCHARLSolder adults |
| spellingShingle | Qian Zhong Lisha Jiang Kang An Lin Zhang Shuangqing Li Zhenmei An Depression and risk of sarcopenia: a national cohort and Mendelian randomization study Frontiers in Psychiatry sarcopenia depression low muscle mass CHARLS older adults |
| title | Depression and risk of sarcopenia: a national cohort and Mendelian randomization study |
| title_full | Depression and risk of sarcopenia: a national cohort and Mendelian randomization study |
| title_fullStr | Depression and risk of sarcopenia: a national cohort and Mendelian randomization study |
| title_full_unstemmed | Depression and risk of sarcopenia: a national cohort and Mendelian randomization study |
| title_short | Depression and risk of sarcopenia: a national cohort and Mendelian randomization study |
| title_sort | depression and risk of sarcopenia a national cohort and mendelian randomization study |
| topic | sarcopenia depression low muscle mass CHARLS older adults |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1263553/full |
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