| Summary: | Research on fish sex determining genes and their mode of action is not only important for elucidating the mechanisms of vertebrate sex determination, but also for fish monosex control breeding. This paper briefly summarizes our current knowledge about vertebrate sex determination, and reviews the progress of research on fish sex determining genes, including their function and their mechanism of action. In recent years, the number of newly uncovered fish sex determining genes has grown rapidly. In contrast, no sex determining genes have been identified in Cyprinid fishes, which constitute most of the aquaculture fish species in China. Technologies such as high-throughput sequencing and gene editing will provide important technical support for the study of sex determining genes in fish, and play an important role in establishing accurate sex-controlling breeding techniques and the creation of new fish germplasm.
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