Inhibition of Insulin-Regulated Aminopeptidase by Imidazo [1,5-α]pyridines—Synthesis and Evaluation

Inhibition of Insulin-Regulated Aminopeptidase by Imidazo [1,5-α]pyridines—Synthesis and Evaluation

Inhibition of insulin-regulated aminopeptidase (IRAP) has been shown to improve cognitive functions in several animal models. Recently, we performed a screening campaign of approximately 10,000 compounds, identifying novel small-molecule-based compounds acting as inhibitors of the enzymatic activity...

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Bibliographic Details
Main Authors: Karin Engen, Thomas Lundbäck, Anubha Yadav, Sharathna Puthiyaparambath, Ulrika Rosenström, Johan Gising, Annika Jenmalm-Jensen, Mathias Hallberg, Mats Larhed
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
IRAP
imidazo [1,5-α]pyridine-based inhibitors
enzyme inhibitor
insulin-regulated aminopeptidase
Online Access:https://www.mdpi.com/1422-0067/25/5/2516

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https://www.mdpi.com/1422-0067/25/5/2516

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