Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis

Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis

Expression of non-native transcriptional activators may be a powerful general method to activate secondary metabolites biosynthetic pathways. PAS-LuxR regulators, whose archetype is PimM, activate the biosynthesis of polyene macrolide antifungals and other antibiotics, and have been shown to be func...

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Bibliographic Details
Main Authors: Yolanda Martínez-Burgo, Javier Santos-Aberturas, Antonio Rodríguez-García, Eva G. Barreales, José Rubén Tormo, Andrew W. Truman, Fernando Reyes, Jesús F. Aparicio, Paloma Liras
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Microbiology
Subjects:
Streptomyces clavuligerus
PimM
PAS-LuxR regulator
transcriptomics
secondary metabolite
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00580/full

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