Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications
The immune system recognizes and attacks non-self antigens, making up the cornerstone of immunity activity against infection. However, during organ transplantation, the immune system also attacks transplanted organs and leads to immune rejection and transplantation failure. Interestingly, although t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.705950/full |
| _version_ | 1819145228033982464 |
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| author | Jin-Yu Sun Rui Wu Rui Wu Rui Wu Jiang Xu Hui-Ying Xue Xiao-Jie Lu Jiansong Ji |
| author_facet | Jin-Yu Sun Rui Wu Rui Wu Rui Wu Jiang Xu Hui-Ying Xue Xiao-Jie Lu Jiansong Ji |
| author_sort | Jin-Yu Sun |
| collection | DOAJ |
| description | The immune system recognizes and attacks non-self antigens, making up the cornerstone of immunity activity against infection. However, during organ transplantation, the immune system also attacks transplanted organs and leads to immune rejection and transplantation failure. Interestingly, although the embryo and placenta are semi-allografts, like transplanted organs, they can induce maternal tolerance and be free of a vigorous immune response. Also, embryo or placenta-related antibodies might adversely affect subsequent organ transplantation despite the immune tolerance during pregnancy. Therefore, the balance between the immune tolerance in maternal-fetal interface and normal infection defense provides a possible desensitization and tolerance strategy to improve transplantation outcomes. A few studies on mechanisms and clinical applications have been performed to explore the relationship between maternal-fetal immune tolerance and organ transplantation. However, up to now, the mechanisms underlying maternal-fetal immune tolerance remain vague. In this review, we provide an overview on the current understanding of immune tolerance mechanisms underlying the maternal-fetal interface, summarize the interconnection between immune tolerance and organ transplantation, and describe the adverse effect of pregnancy alloimmunization on organ transplantation. |
| first_indexed | 2024-12-22T12:54:41Z |
| format | Article |
| id | doaj.art-d6b584e4be584518a45bfb4442f422f5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T12:54:41Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d6b584e4be584518a45bfb4442f422f52022-12-21T18:25:08ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-08-011210.3389/fimmu.2021.705950705950Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical ImplicationsJin-Yu Sun0Rui Wu1Rui Wu2Rui Wu3Jiang Xu4Hui-Ying Xue5Xiao-Jie Lu6Jiansong Ji7Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Digestive Endoscopy, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation, Huai’an Second People’s Hospital and The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, ChinaThe Reproductive Center, Huai’an Maternal and Child Health Care Hospital, Xuzhou Medical University, Huai’an, ChinaDepartment of General Surgery, Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaKey Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital of Zhejiang University/Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, ChinaThe immune system recognizes and attacks non-self antigens, making up the cornerstone of immunity activity against infection. However, during organ transplantation, the immune system also attacks transplanted organs and leads to immune rejection and transplantation failure. Interestingly, although the embryo and placenta are semi-allografts, like transplanted organs, they can induce maternal tolerance and be free of a vigorous immune response. Also, embryo or placenta-related antibodies might adversely affect subsequent organ transplantation despite the immune tolerance during pregnancy. Therefore, the balance between the immune tolerance in maternal-fetal interface and normal infection defense provides a possible desensitization and tolerance strategy to improve transplantation outcomes. A few studies on mechanisms and clinical applications have been performed to explore the relationship between maternal-fetal immune tolerance and organ transplantation. However, up to now, the mechanisms underlying maternal-fetal immune tolerance remain vague. In this review, we provide an overview on the current understanding of immune tolerance mechanisms underlying the maternal-fetal interface, summarize the interconnection between immune tolerance and organ transplantation, and describe the adverse effect of pregnancy alloimmunization on organ transplantation.https://www.frontiersin.org/articles/10.3389/fimmu.2021.705950/fullplacental immune toleranceorgan transplantationimmune rejectionclinical implicationmaternal-fetal interface |
| spellingShingle | Jin-Yu Sun Rui Wu Rui Wu Rui Wu Jiang Xu Hui-Ying Xue Xiao-Jie Lu Jiansong Ji Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications Frontiers in Immunology placental immune tolerance organ transplantation immune rejection clinical implication maternal-fetal interface |
| title | Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications |
| title_full | Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications |
| title_fullStr | Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications |
| title_full_unstemmed | Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications |
| title_short | Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications |
| title_sort | placental immune tolerance and organ transplantation underlying interconnections and clinical implications |
| topic | placental immune tolerance organ transplantation immune rejection clinical implication maternal-fetal interface |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.705950/full |
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