Physical Exercise Does Not Improve Colon Inflammation in Mice Induced Lambda Carrageenan
Inflammatory Bowel Disease (IBD) is a well known reported gastrointestinal tract disease, which the prevalence continous to increase in Southeast Asia and other developing countries. Animal model have already been widely used for gut inflammation study. Lambda (λ) carrageenan is a chemical substance...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga, Faculty of Veterinary Medicine
2020-03-01
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| Series: | Jurnal Medik Veteriner |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/JMV/article/view/16352 |
| _version_ | 1811205137962631168 |
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| author | Ana Qonitatillah Kristanti Wanito Wigati Roedi Irawan |
| author_facet | Ana Qonitatillah Kristanti Wanito Wigati Roedi Irawan |
| author_sort | Ana Qonitatillah |
| collection | DOAJ |
| description | Inflammatory Bowel Disease (IBD) is a well known reported gastrointestinal tract disease, which the prevalence continous to increase in Southeast Asia and other developing countries. Animal model have already been widely used for gut inflammation study. Lambda (λ) carrageenan is a chemical substance which commonly used to induced inflammation in IBD animal models. Physical exercise is a non-pharmacological therapy recommended for IBD. However, further study is needed to determine the effects of this therapy. This study was aimed to determine the physical exercise effect on colon inflammation in mice induced λ-carrageenan. Thirty-eight mice were divided into 2 groups. Control group (C) which induced with λ-carrageenan and treatment group (T) which induced by λ-carrageenan and treadmill exercise. The degree of colon inflammation was obtained by histopathological examination using Hematoxylin-Eosin (HE) staining and inflammation scoring system, which include inflammatory cell infiltration and intestinal architecture. All mice colon samples in both group were inflamed with varying degrees. The treatment group had a higher Inflammatory degree score than control group (p <0.05). Physical exercise does not improved the degree of colon inflammation in mice induced λ-carrageenan due to uncontrolled stress induction and water intake containing λ-carrageenan. |
| first_indexed | 2024-04-12T03:25:31Z |
| format | Article |
| id | doaj.art-d6b64907453b445fa254d958eb183a43 |
| institution | Directory Open Access Journal |
| issn | 2615-7497 2581-012X |
| language | English |
| last_indexed | 2024-04-12T03:25:31Z |
| publishDate | 2020-03-01 |
| publisher | Universitas Airlangga, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Jurnal Medik Veteriner |
| spelling | doaj.art-d6b64907453b445fa254d958eb183a432022-12-22T03:49:44ZengUniversitas Airlangga, Faculty of Veterinary MedicineJurnal Medik Veteriner2615-74972581-012X2020-03-0131576410.20473/jmv.vol3.iss1.2020.57-6413314Physical Exercise Does Not Improve Colon Inflammation in Mice Induced Lambda CarrageenanAna Qonitatillah0Kristanti Wanito Wigati1https://orcid.org/0000-0002-8542-5934Roedi Irawan2https://orcid.org/0000-0001-5999-4773Medical Science Program, Faculty of Medicine, Universitas Airlangga, Unair A-Campus, Tambaksari, Surabaya, East JavaPhysiology Department, Faculty of Medicine, Universitas Airlangga, Unair A-Campus, Tambaksari, Surabaya, East JavaChild Health Department, Nutrition and Metabolic Disease Division, Faculty of Medicine, Universitas Airlangga, Unair A-Campus, Tambaksari, Surabaya, East JavaInflammatory Bowel Disease (IBD) is a well known reported gastrointestinal tract disease, which the prevalence continous to increase in Southeast Asia and other developing countries. Animal model have already been widely used for gut inflammation study. Lambda (λ) carrageenan is a chemical substance which commonly used to induced inflammation in IBD animal models. Physical exercise is a non-pharmacological therapy recommended for IBD. However, further study is needed to determine the effects of this therapy. This study was aimed to determine the physical exercise effect on colon inflammation in mice induced λ-carrageenan. Thirty-eight mice were divided into 2 groups. Control group (C) which induced with λ-carrageenan and treatment group (T) which induced by λ-carrageenan and treadmill exercise. The degree of colon inflammation was obtained by histopathological examination using Hematoxylin-Eosin (HE) staining and inflammation scoring system, which include inflammatory cell infiltration and intestinal architecture. All mice colon samples in both group were inflamed with varying degrees. The treatment group had a higher Inflammatory degree score than control group (p <0.05). Physical exercise does not improved the degree of colon inflammation in mice induced λ-carrageenan due to uncontrolled stress induction and water intake containing λ-carrageenan.https://e-journal.unair.ac.id/JMV/article/view/16352ibdinflammatory cell infiltrationintestinal architectureλ-carrageenanphysical exercisetreadmill |
| spellingShingle | Ana Qonitatillah Kristanti Wanito Wigati Roedi Irawan Physical Exercise Does Not Improve Colon Inflammation in Mice Induced Lambda Carrageenan Jurnal Medik Veteriner ibd inflammatory cell infiltration intestinal architecture λ-carrageenan physical exercise treadmill |
| title | Physical Exercise Does Not Improve Colon Inflammation in Mice Induced Lambda Carrageenan |
| title_full | Physical Exercise Does Not Improve Colon Inflammation in Mice Induced Lambda Carrageenan |
| title_fullStr | Physical Exercise Does Not Improve Colon Inflammation in Mice Induced Lambda Carrageenan |
| title_full_unstemmed | Physical Exercise Does Not Improve Colon Inflammation in Mice Induced Lambda Carrageenan |
| title_short | Physical Exercise Does Not Improve Colon Inflammation in Mice Induced Lambda Carrageenan |
| title_sort | physical exercise does not improve colon inflammation in mice induced lambda carrageenan |
| topic | ibd inflammatory cell infiltration intestinal architecture λ-carrageenan physical exercise treadmill |
| url | https://e-journal.unair.ac.id/JMV/article/view/16352 |
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