Late consequences of chemotherapy on left ventricular function in women with breast cancer
Background: Cardiovascular disease is the main cause of death among breast cancer survivors. Several chemotherapy drugs may cause cardiovascular toxicity. Our study aimed to assess the late effects of chemotherapy on left ventricular (LV) systolic and diastolic function in a group of female breast c...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2022-06-01
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| Series: | Caspian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://caspjim.com/article-1-2862-en.html |
| _version_ | 1818532264823226368 |
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| author | Maryam Nabati Ghasem Janbabai Mohammadreza Najjarpor Jamshid Yazdani |
| author_facet | Maryam Nabati Ghasem Janbabai Mohammadreza Najjarpor Jamshid Yazdani |
| author_sort | Maryam Nabati |
| collection | DOAJ |
| description | Background: Cardiovascular disease is the main cause of death among breast cancer survivors. Several chemotherapy drugs may cause cardiovascular toxicity. Our study aimed to assess the late effects of chemotherapy on left ventricular (LV) systolic and diastolic function in a group of female breast cancer survivors.
Methods: Our study was a case-control study consisted of 60 breast cancer survivors who had undergone chemotherapy for more than 5 years and a control group of 49 women without breast cancer. All patients underwent echocardiography and left ventricular ejection fraction (LVEF), global longitudinal strain (GLS), pulse-Doppler early transmitral peak flow velocity (E wave), early diastolic (e'), and left atrial (LA) diameter were calculated.
Results: The mean LVEF and GLS were reduced in chemotherapy group (51.63±7.93% vs. 55.37±3.50%, P=0.002 and -17.99±3.27% vs. -19.25±2.27%, P=0.025). Also, the chemotherapy group had a larger left ventricular end-systolic internal diameter than the control group (1.74±0.44cm/m2 vs. 1.58±0.22cm/m2, P= 0.011). Logistic regression analysis showed among the different cardiovascular risk factors, chemotherapy had an association with decreasing LVEF.
Conclusion: Breast cancer survivors might have an excess risk of having subclinical LV dysfunction over time. These findings present the potential benefits of echocardiographic assessment in breast cancer survivors. |
| first_indexed | 2024-12-11T17:43:14Z |
| format | Article |
| id | doaj.art-d6bb7a9e53b949ef89a5c60d9a1dc9b4 |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-12-11T17:43:14Z |
| publishDate | 2022-06-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-d6bb7a9e53b949ef89a5c60d9a1dc9b42022-12-22T00:56:28ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722022-06-01133511518Late consequences of chemotherapy on left ventricular function in women with breast cancerMaryam Nabati0Ghasem Janbabai1Mohammadreza Najjarpor2Jamshid Yazdani3 Department of Cardiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Cardiovascular Research Center, Sari, Iran Department of Hematology, Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Department of Biostatics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran Background: Cardiovascular disease is the main cause of death among breast cancer survivors. Several chemotherapy drugs may cause cardiovascular toxicity. Our study aimed to assess the late effects of chemotherapy on left ventricular (LV) systolic and diastolic function in a group of female breast cancer survivors. Methods: Our study was a case-control study consisted of 60 breast cancer survivors who had undergone chemotherapy for more than 5 years and a control group of 49 women without breast cancer. All patients underwent echocardiography and left ventricular ejection fraction (LVEF), global longitudinal strain (GLS), pulse-Doppler early transmitral peak flow velocity (E wave), early diastolic (e'), and left atrial (LA) diameter were calculated. Results: The mean LVEF and GLS were reduced in chemotherapy group (51.63±7.93% vs. 55.37±3.50%, P=0.002 and -17.99±3.27% vs. -19.25±2.27%, P=0.025). Also, the chemotherapy group had a larger left ventricular end-systolic internal diameter than the control group (1.74±0.44cm/m2 vs. 1.58±0.22cm/m2, P= 0.011). Logistic regression analysis showed among the different cardiovascular risk factors, chemotherapy had an association with decreasing LVEF. Conclusion: Breast cancer survivors might have an excess risk of having subclinical LV dysfunction over time. These findings present the potential benefits of echocardiographic assessment in breast cancer survivors.http://caspjim.com/article-1-2862-en.htmlcancercardiotoxicitychemotherapyleft ventricular dysfunctionstrain |
| spellingShingle | Maryam Nabati Ghasem Janbabai Mohammadreza Najjarpor Jamshid Yazdani Late consequences of chemotherapy on left ventricular function in women with breast cancer Caspian Journal of Internal Medicine cancer cardiotoxicity chemotherapy left ventricular dysfunction strain |
| title | Late consequences of chemotherapy on left ventricular function in women with breast cancer |
| title_full | Late consequences of chemotherapy on left ventricular function in women with breast cancer |
| title_fullStr | Late consequences of chemotherapy on left ventricular function in women with breast cancer |
| title_full_unstemmed | Late consequences of chemotherapy on left ventricular function in women with breast cancer |
| title_short | Late consequences of chemotherapy on left ventricular function in women with breast cancer |
| title_sort | late consequences of chemotherapy on left ventricular function in women with breast cancer |
| topic | cancer cardiotoxicity chemotherapy left ventricular dysfunction strain |
| url | http://caspjim.com/article-1-2862-en.html |
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