Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions
Abstract To assess drug-resistant bacterial colonisation rates and associated risk factors in children with complex chronic conditions admitted to a national reference unit in Spain. Cross-sectional study that included all children admitted to our unit from September 2018 to July 2019. Rectal swabs...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11295-5 |
| _version_ | 1818251256658919424 |
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| author | Martin Agud Ines de Medrano Ana Mendez-Echevarria Talia Sainz Federico Román Guillermo Ruiz Carrascoso Luis Escosa-Garcia Clara Molina Amores Francisco José Climent Aroa Rodríguez Marta Garcia-Fernandez de Villalta Cristina Calvo |
| author_facet | Martin Agud Ines de Medrano Ana Mendez-Echevarria Talia Sainz Federico Román Guillermo Ruiz Carrascoso Luis Escosa-Garcia Clara Molina Amores Francisco José Climent Aroa Rodríguez Marta Garcia-Fernandez de Villalta Cristina Calvo |
| author_sort | Martin Agud |
| collection | DOAJ |
| description | Abstract To assess drug-resistant bacterial colonisation rates and associated risk factors in children with complex chronic conditions admitted to a national reference unit in Spain. Cross-sectional study that included all children admitted to our unit from September 2018 to July 2019. Rectal swabs were obtained to determine multidrug-resistant Gram-negative bacilli (MR-GNB) colonisation, and nasal swab to determine S. aureus and methicillin-resistant S. aureus (MRSA) colonisation. Medical records were reviewed. 100 children were included, with a median of four complex chronic conditions. Sixteen percent had S. aureus colonisation, including two MRSA. S. aureus colonisation was associated with technology-dependent children, while being on antibiotic prophylaxis or having undergone antibiotic therapy in the previous month were protective factors. The prevalence of MR-GNB colonisation was 27%, which was associated with immunosuppressive therapy (aOR 31; 2.02–47]; p = 0.01), antibiotic prophylaxis (aOR 4.56; 1.4–14.86; p = 0.012), previously treated skin-infections (aOR 2.9; 1.07–8.14; p = 0.03), surgery in the previous year (aOR 1.4; 1.06–1.8; p = 0.014), and hospital admission in the previous year (aOR 1.79; [1.26–2.56]; p = 0.001). The rate of S. aureus nasal colonisation in this series was not high despite the presence of chronic conditions, and few cases corresponded to MRSA. Antibiotic prophylaxis, immunosuppressive therapies, history of infections, previous surgeries, and length of admission in the previous year were risk factors for MR-GNB colonisation. |
| first_indexed | 2024-12-12T16:05:24Z |
| format | Article |
| id | doaj.art-d6bc125e4a7f459b9c97f294baf31c04 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T16:05:24Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d6bc125e4a7f459b9c97f294baf31c042022-12-22T00:19:20ZengNature PortfolioScientific Reports2045-23222022-05-011211910.1038/s41598-022-11295-5Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditionsMartin Agud0Ines de Medrano1Ana Mendez-Echevarria2Talia Sainz3Federico Román4Guillermo Ruiz Carrascoso5Luis Escosa-Garcia6Clara Molina Amores7Francisco José Climent8Aroa Rodríguez9Marta Garcia-Fernandez de Villalta10Cristina Calvo11Children’s Medically Complex Diseases Unit, La Paz University HospitalPaediatric Department, Universidad Autónoma de MadridPaediatric Infectious and Tropical Diseases Department, Hospital La Paz Research Institute (IdiPAZ), CIBER Infectious Diseases (ISCIII), La Paz University HospitalPaediatric Infectious and Tropical Diseases Department, Hospital La Paz Research Institute (IdiPAZ), CIBER Infectious Diseases (ISCIII), La Paz University HospitalNosocomial Infections Unit, CNM, Carlos III Health InstituteDepartment of Clinical Microbiology, La Paz University HospitalPaediatric Infectious and Tropical Diseases Department, Hospital La Paz Research Institute (IdiPAZ), CIBER Infectious Diseases (ISCIII), La Paz University HospitalChildren’s Medically Complex Diseases Unit, La Paz University HospitalChildren’s Medically Complex Diseases Unit, La Paz University HospitalChildren’s Medically Complex Diseases Unit, La Paz University HospitalChildren’s Medically Complex Diseases Unit, La Paz University HospitalPaediatric Infectious and Tropical Diseases Department, Hospital La Paz Research Institute (IdiPAZ), CIBER Infectious Diseases (ISCIII), La Paz University HospitalAbstract To assess drug-resistant bacterial colonisation rates and associated risk factors in children with complex chronic conditions admitted to a national reference unit in Spain. Cross-sectional study that included all children admitted to our unit from September 2018 to July 2019. Rectal swabs were obtained to determine multidrug-resistant Gram-negative bacilli (MR-GNB) colonisation, and nasal swab to determine S. aureus and methicillin-resistant S. aureus (MRSA) colonisation. Medical records were reviewed. 100 children were included, with a median of four complex chronic conditions. Sixteen percent had S. aureus colonisation, including two MRSA. S. aureus colonisation was associated with technology-dependent children, while being on antibiotic prophylaxis or having undergone antibiotic therapy in the previous month were protective factors. The prevalence of MR-GNB colonisation was 27%, which was associated with immunosuppressive therapy (aOR 31; 2.02–47]; p = 0.01), antibiotic prophylaxis (aOR 4.56; 1.4–14.86; p = 0.012), previously treated skin-infections (aOR 2.9; 1.07–8.14; p = 0.03), surgery in the previous year (aOR 1.4; 1.06–1.8; p = 0.014), and hospital admission in the previous year (aOR 1.79; [1.26–2.56]; p = 0.001). The rate of S. aureus nasal colonisation in this series was not high despite the presence of chronic conditions, and few cases corresponded to MRSA. Antibiotic prophylaxis, immunosuppressive therapies, history of infections, previous surgeries, and length of admission in the previous year were risk factors for MR-GNB colonisation.https://doi.org/10.1038/s41598-022-11295-5 |
| spellingShingle | Martin Agud Ines de Medrano Ana Mendez-Echevarria Talia Sainz Federico Román Guillermo Ruiz Carrascoso Luis Escosa-Garcia Clara Molina Amores Francisco José Climent Aroa Rodríguez Marta Garcia-Fernandez de Villalta Cristina Calvo Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions Scientific Reports |
| title | Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions |
| title_full | Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions |
| title_fullStr | Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions |
| title_full_unstemmed | Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions |
| title_short | Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions |
| title_sort | risk factors for antibiotic resistant bacteria colonisation in children with chronic complex conditions |
| url | https://doi.org/10.1038/s41598-022-11295-5 |
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