Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview
Translation or protein synthesis consists of a complex system of chemical reactions, which ultimately result in decoding of the mRNA and the production of a protein. The complexity of this reaction system makes it difficult to quantitatively connect its input parameters (such as translation factor o...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-04-01
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| Series: | Computational and Structural Biotechnology Journal |
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| Online Access: | http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201204002 |
| _version_ | 1818911658305650688 |
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| author | Tobias von der Haar |
| author_facet | Tobias von der Haar |
| author_sort | Tobias von der Haar |
| collection | DOAJ |
| description | Translation or protein synthesis consists of a complex system of chemical reactions, which ultimately result in decoding of the mRNA and the production of a protein. The complexity of this reaction system makes it difficult to quantitatively connect its input parameters (such as translation factor or ribosome concentrations, codon composition of the mRNA, or energy availability) to output parameters (such as protein synthesis rates or ribosome densities on mRNAs). Mathematical and computational models of translation have now been used for nearly five decades to investigate translation, and to shed light on the relationship between the different reactions in the system. This review gives an overview over the principal approaches used in the modelling efforts, and summarises some of the major findings that were made. |
| first_indexed | 2024-12-19T23:02:12Z |
| format | Article |
| id | doaj.art-d6bdb56620a049f3b10b1dfec803d166 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-19T23:02:12Z |
| publishDate | 2012-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-d6bdb56620a049f3b10b1dfec803d1662022-12-21T20:02:29ZengElsevierComputational and Structural Biotechnology Journal2001-03702012-04-0111e201204002Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overviewTobias von der HaarTranslation or protein synthesis consists of a complex system of chemical reactions, which ultimately result in decoding of the mRNA and the production of a protein. The complexity of this reaction system makes it difficult to quantitatively connect its input parameters (such as translation factor or ribosome concentrations, codon composition of the mRNA, or energy availability) to output parameters (such as protein synthesis rates or ribosome densities on mRNAs). Mathematical and computational models of translation have now been used for nearly five decades to investigate translation, and to shed light on the relationship between the different reactions in the system. This review gives an overview over the principal approaches used in the modelling efforts, and summarises some of the major findings that were made.http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201204002TranslationPolysomeBiosynthesismRNARibosomeGene expression |
| spellingShingle | Tobias von der Haar Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview Computational and Structural Biotechnology Journal Translation Polysome Biosynthesis mRNA Ribosome Gene expression |
| title | Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview |
| title_full | Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview |
| title_fullStr | Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview |
| title_full_unstemmed | Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview |
| title_short | Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview |
| title_sort | mathematical and computational modelling of ribosomal movement and protein synthesis an overview |
| topic | Translation Polysome Biosynthesis mRNA Ribosome Gene expression |
| url | http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201204002 |
| work_keys_str_mv | AT tobiasvonderhaar mathematicalandcomputationalmodellingofribosomalmovementandproteinsynthesisanoverview |