Nrf2 as a modulator of oxidative stress
Nrf2 is active protein presents in the cytoplasm in the cells of the body. In the presence of an activators, Nrf2 can enter the nucleus which bind to Antioxidant Responses Elements (ARE) or otherwise named human ARE (hARE) which control the whole antioxidants activity in human cell. Many factors...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2022-04-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/798 |
| _version_ | 1797223957925986304 |
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| author | Inam Sameh Arif Yassir Mustafa Kamal Israa Burhan Raoof |
| author_facet | Inam Sameh Arif Yassir Mustafa Kamal Israa Burhan Raoof |
| author_sort | Inam Sameh Arif |
| collection | DOAJ |
| description |
Nrf2 is active protein presents in the cytoplasm in the cells of the body. In the presence of an activators, Nrf2 can enter the nucleus which bind to Antioxidant Responses Elements (ARE) or otherwise named human ARE (hARE) which control the whole antioxidants activity in
human cell. Many factors may contribute to defective or overwhelmed cellular antioxidants activities for instances aging and cellular damages. These cellular damages can be produced by free radicals or oxidative stress. In the mechanism, if Nrf2 activated in the nucleus, can caused the production of collaborative antioxidants enzymes especially: catalase, glutathione (GLT) and superoxide dismutase (SOD) as a responsible for detoxification of free radical inside the cells.
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| first_indexed | 2024-04-24T13:45:29Z |
| format | Article |
| id | doaj.art-d6bde6127a5c4ac79b09b12cbef3a6cb |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:45:29Z |
| publishDate | 2022-04-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-d6bde6127a5c4ac79b09b12cbef3a6cb2024-04-04T06:56:29ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2022-04-0121410.32947/ajps.v21i4.798Nrf2 as a modulator of oxidative stressInam Sameh Arif0Yassir Mustafa Kamal1Israa Burhan Raoof2Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriyah UniversityDepartment of Pharmacology and Toxicology, College of Pharmacy, Mustansiriyah UniversityDepartment of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University Nrf2 is active protein presents in the cytoplasm in the cells of the body. In the presence of an activators, Nrf2 can enter the nucleus which bind to Antioxidant Responses Elements (ARE) or otherwise named human ARE (hARE) which control the whole antioxidants activity in human cell. Many factors may contribute to defective or overwhelmed cellular antioxidants activities for instances aging and cellular damages. These cellular damages can be produced by free radicals or oxidative stress. In the mechanism, if Nrf2 activated in the nucleus, can caused the production of collaborative antioxidants enzymes especially: catalase, glutathione (GLT) and superoxide dismutase (SOD) as a responsible for detoxification of free radical inside the cells. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/798 |
| spellingShingle | Inam Sameh Arif Yassir Mustafa Kamal Israa Burhan Raoof Nrf2 as a modulator of oxidative stress Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| title | Nrf2 as a modulator of oxidative stress |
| title_full | Nrf2 as a modulator of oxidative stress |
| title_fullStr | Nrf2 as a modulator of oxidative stress |
| title_full_unstemmed | Nrf2 as a modulator of oxidative stress |
| title_short | Nrf2 as a modulator of oxidative stress |
| title_sort | nrf2 as a modulator of oxidative stress |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/798 |
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