Plasma Levels of Fetuin B and Fibrinogen in Chronic Obstructive Pulmonary Disease: A Preliminary Cross-sectional Study
Introduction: Recent exploratory proteomics study reported increased blood levels of Fetuin B (FETUB) in Chronic Obstructive Pulmonary Disease (COPD). Growing body of evidence demonstrates fibrinogen not only as acute phase reactant but also possesses features advocating as biomarker of COPD....
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2021-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/15377/49391_CE[Ra1]_F[SK]_PF1(MG_SHU)_PFA_PB(MG_KM)_PN(KM).pdf |
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| author | CV Shri Swathini MVP Chowdary |
| author_facet | CV Shri Swathini MVP Chowdary |
| author_sort | CV Shri Swathini |
| collection | DOAJ |
| description | Introduction: Recent exploratory proteomics study reported
increased blood levels of Fetuin B (FETUB) in Chronic
Obstructive Pulmonary Disease (COPD). Growing body of
evidence demonstrates fibrinogen not only as acute phase
reactant but also possesses features advocating as biomarker
of COPD.
Aim: To determine the blood levels of FETUB and fibrinogen
independently as well as in combination COPD and among
severity of COPD.
Materials and Methods: A single-centred cross-sectional study of
eight months duration was conducted during May to December
2017. A total of 76 blood samples (38 COPD patients and 38
controls) were recruited. Based on distribution, parametric and non
parametric statistical tools were used. Analysis of co-variance and
multiple multivariate linear regression models were utilised to assess
the influence of clinical data on FETUB. Steel-Dwass-CritchlowFligner method was employed for multiple pairwise comparisons.
Receiver Operating Characteristic (ROC) curve were generated to
compute cut-off of FETUB, fibrinogen and their combination.
Results: The median age of subjects were 57 years with an IQR
of 50-66 years for controls whereas 58 years (IQR 50-65 years)
for COPD subjects. In comparison to controls, a significant
increase in blood levels of both FETUB and fibrinogen in COPD
and Global Initiative for Chronic Obstructive Lung Disease
(GOLD) stages of COPD was prominent. Among COPD grades,
differences of FETUB levels were significant in GOLD I vs II and
GOLD IV vs I, II and III whereas fibrinogen levels in GOLD III
from GOLD IV. FETUB showed independent correlation with
Forced Expiratory Volume (FEV) 1% pred and severity of COPD.
A moderate improvement in combined (FETUB+fibrinogen)
analysis of control vs COPD was noticed.
Conclusion: The present study demonstrates significant increase
in blood levels of FETUB in COPD and among the severity of
COPD in comparison to fibrinogen. Hence, FETUB can be a more
promising probable inflammatory biomarker in COPD. |
| first_indexed | 2024-12-14T16:21:29Z |
| format | Article |
| id | doaj.art-d6be8d5f8b1d45da8897b80f0e0f5e6f |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T16:21:29Z |
| publishDate | 2021-09-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-d6be8d5f8b1d45da8897b80f0e0f5e6f2022-12-21T22:54:47ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-09-01159BC08BC1310.7860/JCDR/2021/49391.15377Plasma Levels of Fetuin B and Fibrinogen in Chronic Obstructive Pulmonary Disease: A Preliminary Cross-sectional StudyCV Shri Swathini0MVP Chowdary1Residential Intern, Department of Biochemistry, Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamil Nadu, IndiaAssociate Professor, Department of Biochemistry, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India.Introduction: Recent exploratory proteomics study reported increased blood levels of Fetuin B (FETUB) in Chronic Obstructive Pulmonary Disease (COPD). Growing body of evidence demonstrates fibrinogen not only as acute phase reactant but also possesses features advocating as biomarker of COPD. Aim: To determine the blood levels of FETUB and fibrinogen independently as well as in combination COPD and among severity of COPD. Materials and Methods: A single-centred cross-sectional study of eight months duration was conducted during May to December 2017. A total of 76 blood samples (38 COPD patients and 38 controls) were recruited. Based on distribution, parametric and non parametric statistical tools were used. Analysis of co-variance and multiple multivariate linear regression models were utilised to assess the influence of clinical data on FETUB. Steel-Dwass-CritchlowFligner method was employed for multiple pairwise comparisons. Receiver Operating Characteristic (ROC) curve were generated to compute cut-off of FETUB, fibrinogen and their combination. Results: The median age of subjects were 57 years with an IQR of 50-66 years for controls whereas 58 years (IQR 50-65 years) for COPD subjects. In comparison to controls, a significant increase in blood levels of both FETUB and fibrinogen in COPD and Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages of COPD was prominent. Among COPD grades, differences of FETUB levels were significant in GOLD I vs II and GOLD IV vs I, II and III whereas fibrinogen levels in GOLD III from GOLD IV. FETUB showed independent correlation with Forced Expiratory Volume (FEV) 1% pred and severity of COPD. A moderate improvement in combined (FETUB+fibrinogen) analysis of control vs COPD was noticed. Conclusion: The present study demonstrates significant increase in blood levels of FETUB in COPD and among the severity of COPD in comparison to fibrinogen. Hence, FETUB can be a more promising probable inflammatory biomarker in COPD.https://www.jcdr.net/articles/PDF/15377/49391_CE[Ra1]_F[SK]_PF1(MG_SHU)_PFA_PB(MG_KM)_PN(KM).pdfforced expiratory volumeglobal initiative for chronic obstructive lung diseasesmoking and biomass exposure |
| spellingShingle | CV Shri Swathini MVP Chowdary Plasma Levels of Fetuin B and Fibrinogen in Chronic Obstructive Pulmonary Disease: A Preliminary Cross-sectional Study Journal of Clinical and Diagnostic Research forced expiratory volume global initiative for chronic obstructive lung disease smoking and biomass exposure |
| title | Plasma Levels of Fetuin B and Fibrinogen in Chronic Obstructive Pulmonary Disease: A Preliminary Cross-sectional Study |
| title_full | Plasma Levels of Fetuin B and Fibrinogen in Chronic Obstructive Pulmonary Disease: A Preliminary Cross-sectional Study |
| title_fullStr | Plasma Levels of Fetuin B and Fibrinogen in Chronic Obstructive Pulmonary Disease: A Preliminary Cross-sectional Study |
| title_full_unstemmed | Plasma Levels of Fetuin B and Fibrinogen in Chronic Obstructive Pulmonary Disease: A Preliminary Cross-sectional Study |
| title_short | Plasma Levels of Fetuin B and Fibrinogen in Chronic Obstructive Pulmonary Disease: A Preliminary Cross-sectional Study |
| title_sort | plasma levels of fetuin b and fibrinogen in chronic obstructive pulmonary disease a preliminary cross sectional study |
| topic | forced expiratory volume global initiative for chronic obstructive lung disease smoking and biomass exposure |
| url | https://www.jcdr.net/articles/PDF/15377/49391_CE[Ra1]_F[SK]_PF1(MG_SHU)_PFA_PB(MG_KM)_PN(KM).pdf |
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