Scrotal cutaneous verruciform xanthoma with monocyte chemoattractant protein-1 immunohistochemical study: a case report
<p>Abstract</p> <p>Introduction</p> <p>Verruciform xanthoma is a rare, benign lesion characterized by hyperkeratosis and aggregates of foam cell macrophages. Here, we describe a case of verruciform xanthoma on the scrotum, in which the immunohistochemical localization o...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-08-01
|
| Series: | Journal of Medical Case Reports |
| Online Access: | http://www.jmedicalcasereports.com/content/6/1/260 |
| _version_ | 1811304259078062080 |
|---|---|
| author | Ito Chihiro Kitazawac Riko Makita Kenji Watanabe Takafumi Toda Akihiro Haraguchi Ryuma Tanaka Shinji Kitazawa Sohei |
| author_facet | Ito Chihiro Kitazawac Riko Makita Kenji Watanabe Takafumi Toda Akihiro Haraguchi Ryuma Tanaka Shinji Kitazawa Sohei |
| author_sort | Ito Chihiro |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Introduction</p> <p>Verruciform xanthoma is a rare, benign lesion characterized by hyperkeratosis and aggregates of foam cell macrophages. Here, we describe a case of verruciform xanthoma on the scrotum, in which the immunohistochemical localization of monocyte chemoattractant protein-1, a chemokine of the C-C or beta family that has been shown to induce the recruitment of monocytes for injured tissue, was analyzed to determine which cells release chemoattractants for macrophages.</p> <p>Case presentation</p> <p>A 75-year-old Japanese man with a well-defined nodule on the left scrotum was admitted to the hospital. An excision biopsy revealed epidermal papillary proliferation with parakeratosis, hyperkeratosis, and infiltration of foam cell macrophages, whereby a pathological diagnosis of benign cutaneous verruciform xanthoma was made. Immunohistochemically, monocyte chemoattractant protein-1 was observed predominantly on cytokeratin AE1/AE3-positive differentiating keratinocytes in the prickle cell layer. However, while infiltrating macrophages were densely stained for monocyte chemoattractant protein-1, keratinocytes in the basal and parabasal layers were almost negative.</p> <p>Conclusions</p> <p>We demonstrated that keratinocyte-derived monocyte chemoattractant protein-1 plays an important role in the establishment of particular histological features of verruciform xanthoma. However, in the present case, unlike in previous reports, monocyte chemoattractant protein-1 immunostaining in keratinocytes in the basal and parabasal layers was not prominent. We speculate that in the active phase of verruciform xanthoma, when continuous stimuli that release monocyte chemoattractant protein-1 from keratinocytes to the surrounding stromal area are present, the apparent immunostaining of monocyte chemoattractant protein-1 can be underestimated because of the void created by accelerated keratinocyte release from the cytoplasmic fraction.</p> |
| first_indexed | 2024-04-13T08:04:05Z |
| format | Article |
| id | doaj.art-d6bf7968b45043c094d7e4122ea51e16 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-13T08:04:05Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-d6bf7968b45043c094d7e4122ea51e162022-12-22T02:55:13ZengBMCJournal of Medical Case Reports1752-19472012-08-016126010.1186/1752-1947-6-260Scrotal cutaneous verruciform xanthoma with monocyte chemoattractant protein-1 immunohistochemical study: a case reportIto ChihiroKitazawac RikoMakita KenjiWatanabe TakafumiToda AkihiroHaraguchi RyumaTanaka ShinjiKitazawa Sohei<p>Abstract</p> <p>Introduction</p> <p>Verruciform xanthoma is a rare, benign lesion characterized by hyperkeratosis and aggregates of foam cell macrophages. Here, we describe a case of verruciform xanthoma on the scrotum, in which the immunohistochemical localization of monocyte chemoattractant protein-1, a chemokine of the C-C or beta family that has been shown to induce the recruitment of monocytes for injured tissue, was analyzed to determine which cells release chemoattractants for macrophages.</p> <p>Case presentation</p> <p>A 75-year-old Japanese man with a well-defined nodule on the left scrotum was admitted to the hospital. An excision biopsy revealed epidermal papillary proliferation with parakeratosis, hyperkeratosis, and infiltration of foam cell macrophages, whereby a pathological diagnosis of benign cutaneous verruciform xanthoma was made. Immunohistochemically, monocyte chemoattractant protein-1 was observed predominantly on cytokeratin AE1/AE3-positive differentiating keratinocytes in the prickle cell layer. However, while infiltrating macrophages were densely stained for monocyte chemoattractant protein-1, keratinocytes in the basal and parabasal layers were almost negative.</p> <p>Conclusions</p> <p>We demonstrated that keratinocyte-derived monocyte chemoattractant protein-1 plays an important role in the establishment of particular histological features of verruciform xanthoma. However, in the present case, unlike in previous reports, monocyte chemoattractant protein-1 immunostaining in keratinocytes in the basal and parabasal layers was not prominent. We speculate that in the active phase of verruciform xanthoma, when continuous stimuli that release monocyte chemoattractant protein-1 from keratinocytes to the surrounding stromal area are present, the apparent immunostaining of monocyte chemoattractant protein-1 can be underestimated because of the void created by accelerated keratinocyte release from the cytoplasmic fraction.</p>http://www.jmedicalcasereports.com/content/6/1/260 |
| spellingShingle | Ito Chihiro Kitazawac Riko Makita Kenji Watanabe Takafumi Toda Akihiro Haraguchi Ryuma Tanaka Shinji Kitazawa Sohei Scrotal cutaneous verruciform xanthoma with monocyte chemoattractant protein-1 immunohistochemical study: a case report Journal of Medical Case Reports |
| title | Scrotal cutaneous verruciform xanthoma with monocyte chemoattractant protein-1 immunohistochemical study: a case report |
| title_full | Scrotal cutaneous verruciform xanthoma with monocyte chemoattractant protein-1 immunohistochemical study: a case report |
| title_fullStr | Scrotal cutaneous verruciform xanthoma with monocyte chemoattractant protein-1 immunohistochemical study: a case report |
| title_full_unstemmed | Scrotal cutaneous verruciform xanthoma with monocyte chemoattractant protein-1 immunohistochemical study: a case report |
| title_short | Scrotal cutaneous verruciform xanthoma with monocyte chemoattractant protein-1 immunohistochemical study: a case report |
| title_sort | scrotal cutaneous verruciform xanthoma with monocyte chemoattractant protein 1 immunohistochemical study a case report |
| url | http://www.jmedicalcasereports.com/content/6/1/260 |
| work_keys_str_mv | AT itochihiro scrotalcutaneousverruciformxanthomawithmonocytechemoattractantprotein1immunohistochemicalstudyacasereport AT kitazawacriko scrotalcutaneousverruciformxanthomawithmonocytechemoattractantprotein1immunohistochemicalstudyacasereport AT makitakenji scrotalcutaneousverruciformxanthomawithmonocytechemoattractantprotein1immunohistochemicalstudyacasereport AT watanabetakafumi scrotalcutaneousverruciformxanthomawithmonocytechemoattractantprotein1immunohistochemicalstudyacasereport AT todaakihiro scrotalcutaneousverruciformxanthomawithmonocytechemoattractantprotein1immunohistochemicalstudyacasereport AT haraguchiryuma scrotalcutaneousverruciformxanthomawithmonocytechemoattractantprotein1immunohistochemicalstudyacasereport AT tanakashinji scrotalcutaneousverruciformxanthomawithmonocytechemoattractantprotein1immunohistochemicalstudyacasereport AT kitazawasohei scrotalcutaneousverruciformxanthomawithmonocytechemoattractantprotein1immunohistochemicalstudyacasereport |