Clinical and Ultrasonographic Profile of Adalimumab-treated Hidradenitis Suppurativa Patients: A Real-life Monocentric Experience
Ultrasonography has proven useful for diagnosis and treatment monitoring in patients with hidradenitis suppurativa. The aim of this study was to assess the clinical response to adalimumab using ultrasound findings. This prospective study collected data on demographic features, disease severity, and...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Journals Sweden
2020-06-01
|
| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3520
|
| _version_ | 1819350226192826368 |
|---|---|
| author | Andrea Chiricozzi Giulia Giovanardi Simone Garcovich Dalma Malvaso Giacomo Caldarola Barbara Fossati Cristina Guerriero Clara De Simone Ketty Peris |
| author_facet | Andrea Chiricozzi Giulia Giovanardi Simone Garcovich Dalma Malvaso Giacomo Caldarola Barbara Fossati Cristina Guerriero Clara De Simone Ketty Peris |
| author_sort | Andrea Chiricozzi |
| collection | DOAJ |
| description | Ultrasonography has proven useful for diagnosis and treatment monitoring in patients with hidradenitis suppurativa. The aim of this study was to assess the clinical response to adalimumab using ultrasound findings. This prospective study collected data on demographic features, disease severity, and hidradenitis suppurativa findings from patients with hidradenitis suppurativa treated with adalimumab. Generalized estimating equations investigated relationships between disease severity measures and clinical/demographic variables. The study included a total of 41 patients with hidradenitis suppurativa who were treated with adalimumab for a mean period of 50.8 ± 32.2 weeks; range 6–108 weeks). Clinical improvement was observed during adalimumab therapy, with a progressively greater number of patients achieving HiSCR50 response (36.4% at week 52). Disease duration was identified as the most relevant clinical variable affecting disease severity and treatment response. Treatment response was also influenced by treatment duration, with a 4% greater likelihood of achieving HiSCR50 response at each time-point. At the ultrasound examination, subcutaneous involvement of hidradenitis suppurativa lesions was identified as a predictive negative factor for clinical response to adalimumab (HiSCR50 achievement). |
| first_indexed | 2024-12-24T19:13:03Z |
| format | Article |
| id | doaj.art-d6c08045b1304ba790d84f787707bca3 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-12-24T19:13:03Z |
| publishDate | 2020-06-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-d6c08045b1304ba790d84f787707bca32022-12-21T16:42:57ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572020-06-0110013adv0017210.2340/00015555-35205775Clinical and Ultrasonographic Profile of Adalimumab-treated Hidradenitis Suppurativa Patients: A Real-life Monocentric ExperienceAndrea Chiricozzi0Giulia GiovanardiSimone GarcovichDalma MalvasoGiacomo CaldarolaBarbara FossatiCristina GuerrieroClara De SimoneKetty Peris Institute of Dermatology, Catholic University, Largo Agostino Gemelli 8, IT-00168 Rome, Italy. E-mail: Institute of Dermatology, Catholic University, Largo Agostino Gemelli 8, IT-00168 Rome, Italy. E-mail: chiricozziandrea@gmail.com. Ultrasonography has proven useful for diagnosis and treatment monitoring in patients with hidradenitis suppurativa. The aim of this study was to assess the clinical response to adalimumab using ultrasound findings. This prospective study collected data on demographic features, disease severity, and hidradenitis suppurativa findings from patients with hidradenitis suppurativa treated with adalimumab. Generalized estimating equations investigated relationships between disease severity measures and clinical/demographic variables. The study included a total of 41 patients with hidradenitis suppurativa who were treated with adalimumab for a mean period of 50.8 ± 32.2 weeks; range 6–108 weeks). Clinical improvement was observed during adalimumab therapy, with a progressively greater number of patients achieving HiSCR50 response (36.4% at week 52). Disease duration was identified as the most relevant clinical variable affecting disease severity and treatment response. Treatment response was also influenced by treatment duration, with a 4% greater likelihood of achieving HiSCR50 response at each time-point. At the ultrasound examination, subcutaneous involvement of hidradenitis suppurativa lesions was identified as a predictive negative factor for clinical response to adalimumab (HiSCR50 achievement). https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3520 hidradenitis suppurativa adalimumab hiscr50, real-world ultrasound eco-color-doppler |
| spellingShingle | Andrea Chiricozzi Giulia Giovanardi Simone Garcovich Dalma Malvaso Giacomo Caldarola Barbara Fossati Cristina Guerriero Clara De Simone Ketty Peris Clinical and Ultrasonographic Profile of Adalimumab-treated Hidradenitis Suppurativa Patients: A Real-life Monocentric Experience Acta Dermato-Venereologica hidradenitis suppurativa adalimumab hiscr50, real-world ultrasound eco-color-doppler |
| title | Clinical and Ultrasonographic Profile of Adalimumab-treated Hidradenitis Suppurativa Patients: A Real-life Monocentric Experience |
| title_full | Clinical and Ultrasonographic Profile of Adalimumab-treated Hidradenitis Suppurativa Patients: A Real-life Monocentric Experience |
| title_fullStr | Clinical and Ultrasonographic Profile of Adalimumab-treated Hidradenitis Suppurativa Patients: A Real-life Monocentric Experience |
| title_full_unstemmed | Clinical and Ultrasonographic Profile of Adalimumab-treated Hidradenitis Suppurativa Patients: A Real-life Monocentric Experience |
| title_short | Clinical and Ultrasonographic Profile of Adalimumab-treated Hidradenitis Suppurativa Patients: A Real-life Monocentric Experience |
| title_sort | clinical and ultrasonographic profile of adalimumab treated hidradenitis suppurativa patients a real life monocentric experience |
| topic | hidradenitis suppurativa adalimumab hiscr50, real-world ultrasound eco-color-doppler |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3520
|
| work_keys_str_mv | AT andreachiricozzi clinicalandultrasonographicprofileofadalimumabtreatedhidradenitissuppurativapatientsareallifemonocentricexperience AT giuliagiovanardi clinicalandultrasonographicprofileofadalimumabtreatedhidradenitissuppurativapatientsareallifemonocentricexperience AT simonegarcovich clinicalandultrasonographicprofileofadalimumabtreatedhidradenitissuppurativapatientsareallifemonocentricexperience AT dalmamalvaso clinicalandultrasonographicprofileofadalimumabtreatedhidradenitissuppurativapatientsareallifemonocentricexperience AT giacomocaldarola clinicalandultrasonographicprofileofadalimumabtreatedhidradenitissuppurativapatientsareallifemonocentricexperience AT barbarafossati clinicalandultrasonographicprofileofadalimumabtreatedhidradenitissuppurativapatientsareallifemonocentricexperience AT cristinaguerriero clinicalandultrasonographicprofileofadalimumabtreatedhidradenitissuppurativapatientsareallifemonocentricexperience AT claradesimone clinicalandultrasonographicprofileofadalimumabtreatedhidradenitissuppurativapatientsareallifemonocentricexperience AT kettyperis clinicalandultrasonographicprofileofadalimumabtreatedhidradenitissuppurativapatientsareallifemonocentricexperience |