Maternal and umbilical cord blood levels of leptin in pre-eclamptic and healthy pregnant women: A comparative cross-sectional study
Background: Pre-eclampsia is a multi-systemic disease with its attendant increased maternal and perinatal morbidities and mortality. It has been hypothesized that leptin contributes immensely to the natural history of pre-eclampsia. However, there is considerable disagreement in the reports of exist...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-12-01
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| Series: | Women's Health |
| Online Access: | https://doi.org/10.1177/17455057231213272 |
| _version_ | 1797404673103101952 |
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| author | Lazarus Ugochukwu Okafor George Uchenna Eleje Joseph Ifeanyichukwu Ikechebelu Emmanuel Onyebuchi Ugwu Obi Betrand Nwosu Okechukwu Christian Ikpeze Gerald Okanandu Udigwe Ahizechukwu Chigoziem Eke Samuel A Okoli Charlotte Blanche Oguejiofor Chukwudi Anthony Ogabido Divinefavour Echezona Malachy Ifeanyichukwu Jude Ofor Chigozie Geoffrey Okafor |
| author_facet | Lazarus Ugochukwu Okafor George Uchenna Eleje Joseph Ifeanyichukwu Ikechebelu Emmanuel Onyebuchi Ugwu Obi Betrand Nwosu Okechukwu Christian Ikpeze Gerald Okanandu Udigwe Ahizechukwu Chigoziem Eke Samuel A Okoli Charlotte Blanche Oguejiofor Chukwudi Anthony Ogabido Divinefavour Echezona Malachy Ifeanyichukwu Jude Ofor Chigozie Geoffrey Okafor |
| author_sort | Lazarus Ugochukwu Okafor |
| collection | DOAJ |
| description | Background: Pre-eclampsia is a multi-systemic disease with its attendant increased maternal and perinatal morbidities and mortality. It has been hypothesized that leptin contributes immensely to the natural history of pre-eclampsia. However, there is considerable disagreement in the reports of existing research work on the link between fetomaternal serum leptin levels and pre-eclampsia. Objective: To determine and compare the maternal and umbilical cord sera levels of leptin in women with pre-eclampsia and healthy pregnant women. Study design: This is an analytical cross-sectional study. Methods: The study involved consenting 120 pregnant participants (60 on each arm). Pregnant women diagnosed with pre-eclampsia constituted the investigation group, while the controls were normotensive pregnant women. They were matched for maternal age and body mass index. Venous blood specimens were obtained from the participants for assessment of the serum leptin concentration while umbilical cord blood samples were obtained following delivery of the neonate in advance of the removal of the placenta. The collected blood samples were analysed for the levels of leptin in a blinded pattern. The primary outcome measures were maternal serum leptin levels and umbilical cord serum leptin levels. Results: Mean maternal serum leptin concentration in the pre-eclampsia group was significantly higher than that in the control group (24.88 ± 3.92 vs. 15.03 ± 2.98ng/mL, p < 0.001). Similarly, maternal serum leptin concentration was significantly higher in participants with severe pre-eclampsia compared with those with mild pre-eclampsia (25.91 ± 3.5 vs. 22.83 ± 4.02ng/mL, p = 0.003). However, the mean umbilical cord serum leptin level in the pre-eclampsia group was significantly lower than in the control group (6.43 ± 2.08 vs. 7.27 ± 2.24; p = 0.034). There was a weak positive correlation between maternal serum leptin level and neonatal umbilical serum leptin level in the pre-eclamptic group ( r = 0.21, p = 0.04). Conclusion: Maternal serum leptin concentration is significantly increased in women with pre-eclampsia, compared with their normotensive counterparts. This increase becomes even more pronounced as the severity of the disease progresses. Maternal serum leptin assessment has the potential to become a veritable tool in the diagnosis and monitoring of pregnancies complicated by pre-eclampsia. |
| first_indexed | 2024-03-09T02:59:22Z |
| format | Article |
| id | doaj.art-d6c0e566e03f4115a6fce48b973dbb52 |
| institution | Directory Open Access Journal |
| issn | 1745-5065 |
| language | English |
| last_indexed | 2024-03-09T02:59:22Z |
| publishDate | 2023-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Women's Health |
| spelling | doaj.art-d6c0e566e03f4115a6fce48b973dbb522023-12-04T20:33:45ZengSAGE PublishingWomen's Health1745-50652023-12-011910.1177/17455057231213272Maternal and umbilical cord blood levels of leptin in pre-eclamptic and healthy pregnant women: A comparative cross-sectional studyLazarus Ugochukwu Okafor0George Uchenna Eleje1Joseph Ifeanyichukwu Ikechebelu2Emmanuel Onyebuchi Ugwu3Obi Betrand Nwosu4Okechukwu Christian Ikpeze5Gerald Okanandu Udigwe6Ahizechukwu Chigoziem Eke7Samuel A Okoli8Charlotte Blanche Oguejiofor9Chukwudi Anthony Ogabido10Divinefavour Echezona Malachy11Ifeanyichukwu Jude Ofor12Chigozie Geoffrey Okafor13Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, NigeriaEffective Care Research Unit, Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Nnewi, NigeriaEffective Care Research Unit, Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Nnewi, NigeriaDepartment of Obstetrics and Gynaecology, College of Medicine, University of Nigeria Teaching Hospital, Enugu, NigeriaDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, NigeriaDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, NigeriaEffective Care Research Unit, Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Nnewi, NigeriaDivision of Maternal and Fetal Medicine, Department of Gynaecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USAChidera Hospital and Maternity, Nnewi, NigeriaDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, NigeriaDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, NigeriaNnamdi Azikiwe University Teaching Hospital, Nnewi, NigeriaDepartment of Obstetrics and Gynaecology, ESUT College of Medicine, Enugu, NigeriaDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, NigeriaBackground: Pre-eclampsia is a multi-systemic disease with its attendant increased maternal and perinatal morbidities and mortality. It has been hypothesized that leptin contributes immensely to the natural history of pre-eclampsia. However, there is considerable disagreement in the reports of existing research work on the link between fetomaternal serum leptin levels and pre-eclampsia. Objective: To determine and compare the maternal and umbilical cord sera levels of leptin in women with pre-eclampsia and healthy pregnant women. Study design: This is an analytical cross-sectional study. Methods: The study involved consenting 120 pregnant participants (60 on each arm). Pregnant women diagnosed with pre-eclampsia constituted the investigation group, while the controls were normotensive pregnant women. They were matched for maternal age and body mass index. Venous blood specimens were obtained from the participants for assessment of the serum leptin concentration while umbilical cord blood samples were obtained following delivery of the neonate in advance of the removal of the placenta. The collected blood samples were analysed for the levels of leptin in a blinded pattern. The primary outcome measures were maternal serum leptin levels and umbilical cord serum leptin levels. Results: Mean maternal serum leptin concentration in the pre-eclampsia group was significantly higher than that in the control group (24.88 ± 3.92 vs. 15.03 ± 2.98ng/mL, p < 0.001). Similarly, maternal serum leptin concentration was significantly higher in participants with severe pre-eclampsia compared with those with mild pre-eclampsia (25.91 ± 3.5 vs. 22.83 ± 4.02ng/mL, p = 0.003). However, the mean umbilical cord serum leptin level in the pre-eclampsia group was significantly lower than in the control group (6.43 ± 2.08 vs. 7.27 ± 2.24; p = 0.034). There was a weak positive correlation between maternal serum leptin level and neonatal umbilical serum leptin level in the pre-eclamptic group ( r = 0.21, p = 0.04). Conclusion: Maternal serum leptin concentration is significantly increased in women with pre-eclampsia, compared with their normotensive counterparts. This increase becomes even more pronounced as the severity of the disease progresses. Maternal serum leptin assessment has the potential to become a veritable tool in the diagnosis and monitoring of pregnancies complicated by pre-eclampsia.https://doi.org/10.1177/17455057231213272 |
| spellingShingle | Lazarus Ugochukwu Okafor George Uchenna Eleje Joseph Ifeanyichukwu Ikechebelu Emmanuel Onyebuchi Ugwu Obi Betrand Nwosu Okechukwu Christian Ikpeze Gerald Okanandu Udigwe Ahizechukwu Chigoziem Eke Samuel A Okoli Charlotte Blanche Oguejiofor Chukwudi Anthony Ogabido Divinefavour Echezona Malachy Ifeanyichukwu Jude Ofor Chigozie Geoffrey Okafor Maternal and umbilical cord blood levels of leptin in pre-eclamptic and healthy pregnant women: A comparative cross-sectional study Women's Health |
| title | Maternal and umbilical cord blood levels of leptin in pre-eclamptic and healthy pregnant women: A comparative cross-sectional study |
| title_full | Maternal and umbilical cord blood levels of leptin in pre-eclamptic and healthy pregnant women: A comparative cross-sectional study |
| title_fullStr | Maternal and umbilical cord blood levels of leptin in pre-eclamptic and healthy pregnant women: A comparative cross-sectional study |
| title_full_unstemmed | Maternal and umbilical cord blood levels of leptin in pre-eclamptic and healthy pregnant women: A comparative cross-sectional study |
| title_short | Maternal and umbilical cord blood levels of leptin in pre-eclamptic and healthy pregnant women: A comparative cross-sectional study |
| title_sort | maternal and umbilical cord blood levels of leptin in pre eclamptic and healthy pregnant women a comparative cross sectional study |
| url | https://doi.org/10.1177/17455057231213272 |
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