Fine Wrinkle Improvement through Bioactive Materials That Modulate <i>EDAR</i> and <i>BNC2</i> Gene Expression
Skin aging is a multifaceted biological phenomenon influenced by a combination of intrinsic or extrinsic factors. There is an increasing interest in anti-aging materials including components that improve skin wrinkles. Despite the availability of several such wrinkle-improving materials, the demand...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/3/279 |
| _version_ | 1797241897215852544 |
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| author | Seonju Lee Sanghyun Ye Mina Kim Hyejin Lee Seung-Hyun Jun Nae-Gyu Kang |
| author_facet | Seonju Lee Sanghyun Ye Mina Kim Hyejin Lee Seung-Hyun Jun Nae-Gyu Kang |
| author_sort | Seonju Lee |
| collection | DOAJ |
| description | Skin aging is a multifaceted biological phenomenon influenced by a combination of intrinsic or extrinsic factors. There is an increasing interest in anti-aging materials including components that improve skin wrinkles. Despite the availability of several such wrinkle-improving materials, the demand for ingredients with outstanding efficacy is increasing. Therefore, this study aimed to explore the mechanisms of wrinkle-related genes reported in previous genome-wide association studies (GWASs), identify materials that regulate these genes, and develop an effective anti-wrinkle formula containing the active ingredients that regulate the expression of these genes. We selected two candidate genes, <i>EDAR</i> and <i>BNC2</i>, that are reportedly related to periorbital wrinkles. We investigated their functions in the skin through in vitro experiments using human skin cell lines (keratinocytes and fibroblasts). Moreover, we identified ingredients that regulate the expression of these two genes and confirmed their efficacy through in vitro experiments using the skin cell lines. Finally, we developed a formula containing these ingredients and confirmed that it enhanced dermal collagen in the 3D skin and improved fine wrinkles under the eyes more effectively than retinol in humans, when applied for 8 weeks. Our results are significant and relevant, as we have discovered a special formula for wrinkle improvement with reliable efficacy that surpasses the efficacy of retinol and does not cause side-effects such as skin irritation. |
| first_indexed | 2024-04-24T18:30:37Z |
| format | Article |
| id | doaj.art-d6c11cc0ae7d4067b55943b4fa359d6e |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-04-24T18:30:37Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-d6c11cc0ae7d4067b55943b4fa359d6e2024-03-27T13:27:51ZengMDPI AGBiomolecules2218-273X2024-02-0114327910.3390/biom14030279Fine Wrinkle Improvement through Bioactive Materials That Modulate <i>EDAR</i> and <i>BNC2</i> Gene ExpressionSeonju Lee0Sanghyun Ye1Mina Kim2Hyejin Lee3Seung-Hyun Jun4Nae-Gyu Kang5LG Household and Health Care, R & D Center, Seoul 07795, Republic of KoreaLG Household and Health Care, R & D Center, Seoul 07795, Republic of KoreaLG Household and Health Care, R & D Center, Seoul 07795, Republic of KoreaLG Household and Health Care, R & D Center, Seoul 07795, Republic of KoreaLG Household and Health Care, R & D Center, Seoul 07795, Republic of KoreaLG Household and Health Care, R & D Center, Seoul 07795, Republic of KoreaSkin aging is a multifaceted biological phenomenon influenced by a combination of intrinsic or extrinsic factors. There is an increasing interest in anti-aging materials including components that improve skin wrinkles. Despite the availability of several such wrinkle-improving materials, the demand for ingredients with outstanding efficacy is increasing. Therefore, this study aimed to explore the mechanisms of wrinkle-related genes reported in previous genome-wide association studies (GWASs), identify materials that regulate these genes, and develop an effective anti-wrinkle formula containing the active ingredients that regulate the expression of these genes. We selected two candidate genes, <i>EDAR</i> and <i>BNC2</i>, that are reportedly related to periorbital wrinkles. We investigated their functions in the skin through in vitro experiments using human skin cell lines (keratinocytes and fibroblasts). Moreover, we identified ingredients that regulate the expression of these two genes and confirmed their efficacy through in vitro experiments using the skin cell lines. Finally, we developed a formula containing these ingredients and confirmed that it enhanced dermal collagen in the 3D skin and improved fine wrinkles under the eyes more effectively than retinol in humans, when applied for 8 weeks. Our results are significant and relevant, as we have discovered a special formula for wrinkle improvement with reliable efficacy that surpasses the efficacy of retinol and does not cause side-effects such as skin irritation.https://www.mdpi.com/2218-273X/14/3/279skin agingfine wrinklewrinkle improvementcosmetic ingredientsGWAS |
| spellingShingle | Seonju Lee Sanghyun Ye Mina Kim Hyejin Lee Seung-Hyun Jun Nae-Gyu Kang Fine Wrinkle Improvement through Bioactive Materials That Modulate <i>EDAR</i> and <i>BNC2</i> Gene Expression Biomolecules skin aging fine wrinkle wrinkle improvement cosmetic ingredients GWAS |
| title | Fine Wrinkle Improvement through Bioactive Materials That Modulate <i>EDAR</i> and <i>BNC2</i> Gene Expression |
| title_full | Fine Wrinkle Improvement through Bioactive Materials That Modulate <i>EDAR</i> and <i>BNC2</i> Gene Expression |
| title_fullStr | Fine Wrinkle Improvement through Bioactive Materials That Modulate <i>EDAR</i> and <i>BNC2</i> Gene Expression |
| title_full_unstemmed | Fine Wrinkle Improvement through Bioactive Materials That Modulate <i>EDAR</i> and <i>BNC2</i> Gene Expression |
| title_short | Fine Wrinkle Improvement through Bioactive Materials That Modulate <i>EDAR</i> and <i>BNC2</i> Gene Expression |
| title_sort | fine wrinkle improvement through bioactive materials that modulate i edar i and i bnc2 i gene expression |
| topic | skin aging fine wrinkle wrinkle improvement cosmetic ingredients GWAS |
| url | https://www.mdpi.com/2218-273X/14/3/279 |
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