The 12 month impact of continuous insulin infusion therapy on glycaemic control in adults with type 1 diabetes, at the Townsville hospital, Queensland - A retrospective study

<p class="Default"><strong>Aims: </strong>The purpose of this study was to assess the impact of continuous subcutaneous insulin infusion therapy (CSII) on glycosylated haemoglobin level (HbA1c), total daily dose of insulin (TDD), weight, episodes of diabetic ketoacidosis...

Full description

Bibliographic Details
Main Authors: Suji Prabhaharan, Vasant Shenoy, Kunwarjit Sangla
Format: Article
Language:English
Published: Sri Lanka College of Endocrinologists 2019-04-01
Series:Sri Lanka Journal of Diabetes Endocrinology and Metabolism
Subjects:
Online Access:https://sjdem.sljol.info/articles/7294
_version_ 1818355426230534144
author Suji Prabhaharan
Vasant Shenoy
Kunwarjit Sangla
author_facet Suji Prabhaharan
Vasant Shenoy
Kunwarjit Sangla
author_sort Suji Prabhaharan
collection DOAJ
description <p class="Default"><strong>Aims: </strong>The purpose of this study was to assess the impact of continuous subcutaneous insulin infusion therapy (CSII) on glycosylated haemoglobin level (HbA1c), total daily dose of insulin (TDD), weight, episodes of diabetic ketoacidosis (DKA), severe hypoglycaemia, hospital admissions due to any other causes at 12 months of CSII therapy and to identify the predictive factors for good response to treatment, in patients attending the Townsville hospital diabetes centre.</p><p class="Default"> </p><p class="Default"><strong>Methodology</strong>: This is a retrospective quality assurance single centre study. A total of 105 type 1 diabetes patients on continuous subcutaneous insulin infusion (CSII) were identified from 1st January 2001 to 31st December 2014 of whom; only 52 patients had sufficient data to be included in the study. The HbA1c, total daily dose of insulin and weight were collected 4 months before, after and at 12 months of CSII therapy. Patients demographic details, variables related to disease, treatment and follow up were also recorded.</p><p class="Default"> </p><p class="Default"><strong>Results: </strong>Among the 52 patients analysed, 34.6% were males. The base line median HbA1c for females and males were 8.5% and 8.6% respectively. A significant reduction in baseline median HbA1c (8.6%) was noted both at 4 months {0.6%, (p=0.035)} and 12 months {0.7% (p=0.001)} of continuous subcutaneous insulin infusion therapy. The statistically significant reduction in HbA1c at 4 months was maintained at 12 months (p=0.025). At 12 months of CSII therapy a median HbA1c level of 7.7% was noted in those more than thirty years and 8.6% in less than 30 years of age. The median HbA1c was 7.8% in those who had diabetes for more than 10 years and 8% in less than 10 years. There was no difference in the median HbA1c in females (7.8%) and males (7.9%) at 12months of CSII therapy. At 4 months, the greatest reduction in HbA1c (1.1%) was observed in those who had a base line HbA1c of &gt; 10%. A significant reduction in baseline median total daily dose (TDD) of insulin (57 units) noted both at 4 months (29.9 units (p&lt;0.001) and 12 months (25u (p&lt;0.001). There was no significant variation noted in the weight over 12 months.</p><p class="Default"> </p><strong>Conclusions</strong>: This study adds to the existing literature that continuous subcutaneous insulin infusion therapy significantly improves glycaemic control, reduced the total daily dose of insulin and had no effect on weight over 12 months. In our study age &lt; 30 years and HbA1c of &gt; 10% prior to commencement of therapy are predictors of poor glycaemic outcome at 12 months. Duration of diabetes and gender did not influence the glycaemic outcomes at 12 months.
first_indexed 2024-12-13T19:41:08Z
format Article
id doaj.art-d6c14f49cdb74f54aa9b12d4bb4701ce
institution Directory Open Access Journal
issn 2012-998X
language English
last_indexed 2024-12-13T19:41:08Z
publishDate 2019-04-01
publisher Sri Lanka College of Endocrinologists
record_format Article
series Sri Lanka Journal of Diabetes Endocrinology and Metabolism
spelling doaj.art-d6c14f49cdb74f54aa9b12d4bb4701ce2022-12-21T23:33:42ZengSri Lanka College of EndocrinologistsSri Lanka Journal of Diabetes Endocrinology and Metabolism2012-998X2019-04-019131010.4038/sjdem.v9i1.72945603The 12 month impact of continuous insulin infusion therapy on glycaemic control in adults with type 1 diabetes, at the Townsville hospital, Queensland - A retrospective studySuji Prabhaharan0Vasant Shenoy1Kunwarjit Sangla2Townsville Hospital, QueenslandTownsville Hospital, QueenslandTownsville Hospital, Queensland<p class="Default"><strong>Aims: </strong>The purpose of this study was to assess the impact of continuous subcutaneous insulin infusion therapy (CSII) on glycosylated haemoglobin level (HbA1c), total daily dose of insulin (TDD), weight, episodes of diabetic ketoacidosis (DKA), severe hypoglycaemia, hospital admissions due to any other causes at 12 months of CSII therapy and to identify the predictive factors for good response to treatment, in patients attending the Townsville hospital diabetes centre.</p><p class="Default"> </p><p class="Default"><strong>Methodology</strong>: This is a retrospective quality assurance single centre study. A total of 105 type 1 diabetes patients on continuous subcutaneous insulin infusion (CSII) were identified from 1st January 2001 to 31st December 2014 of whom; only 52 patients had sufficient data to be included in the study. The HbA1c, total daily dose of insulin and weight were collected 4 months before, after and at 12 months of CSII therapy. Patients demographic details, variables related to disease, treatment and follow up were also recorded.</p><p class="Default"> </p><p class="Default"><strong>Results: </strong>Among the 52 patients analysed, 34.6% were males. The base line median HbA1c for females and males were 8.5% and 8.6% respectively. A significant reduction in baseline median HbA1c (8.6%) was noted both at 4 months {0.6%, (p=0.035)} and 12 months {0.7% (p=0.001)} of continuous subcutaneous insulin infusion therapy. The statistically significant reduction in HbA1c at 4 months was maintained at 12 months (p=0.025). At 12 months of CSII therapy a median HbA1c level of 7.7% was noted in those more than thirty years and 8.6% in less than 30 years of age. The median HbA1c was 7.8% in those who had diabetes for more than 10 years and 8% in less than 10 years. There was no difference in the median HbA1c in females (7.8%) and males (7.9%) at 12months of CSII therapy. At 4 months, the greatest reduction in HbA1c (1.1%) was observed in those who had a base line HbA1c of &gt; 10%. A significant reduction in baseline median total daily dose (TDD) of insulin (57 units) noted both at 4 months (29.9 units (p&lt;0.001) and 12 months (25u (p&lt;0.001). There was no significant variation noted in the weight over 12 months.</p><p class="Default"> </p><strong>Conclusions</strong>: This study adds to the existing literature that continuous subcutaneous insulin infusion therapy significantly improves glycaemic control, reduced the total daily dose of insulin and had no effect on weight over 12 months. In our study age &lt; 30 years and HbA1c of &gt; 10% prior to commencement of therapy are predictors of poor glycaemic outcome at 12 months. Duration of diabetes and gender did not influence the glycaemic outcomes at 12 months.https://sjdem.sljol.info/articles/729412 month, continuous subcutaneous insulin infusion, type 1 diabetes, glycaemic , predictive factors
spellingShingle Suji Prabhaharan
Vasant Shenoy
Kunwarjit Sangla
The 12 month impact of continuous insulin infusion therapy on glycaemic control in adults with type 1 diabetes, at the Townsville hospital, Queensland - A retrospective study
Sri Lanka Journal of Diabetes Endocrinology and Metabolism
12 month, continuous subcutaneous insulin infusion, type 1 diabetes, glycaemic , predictive factors
title The 12 month impact of continuous insulin infusion therapy on glycaemic control in adults with type 1 diabetes, at the Townsville hospital, Queensland - A retrospective study
title_full The 12 month impact of continuous insulin infusion therapy on glycaemic control in adults with type 1 diabetes, at the Townsville hospital, Queensland - A retrospective study
title_fullStr The 12 month impact of continuous insulin infusion therapy on glycaemic control in adults with type 1 diabetes, at the Townsville hospital, Queensland - A retrospective study
title_full_unstemmed The 12 month impact of continuous insulin infusion therapy on glycaemic control in adults with type 1 diabetes, at the Townsville hospital, Queensland - A retrospective study
title_short The 12 month impact of continuous insulin infusion therapy on glycaemic control in adults with type 1 diabetes, at the Townsville hospital, Queensland - A retrospective study
title_sort 12 month impact of continuous insulin infusion therapy on glycaemic control in adults with type 1 diabetes at the townsville hospital queensland a retrospective study
topic 12 month, continuous subcutaneous insulin infusion, type 1 diabetes, glycaemic , predictive factors
url https://sjdem.sljol.info/articles/7294
work_keys_str_mv AT sujiprabhaharan the12monthimpactofcontinuousinsulininfusiontherapyonglycaemiccontrolinadultswithtype1diabetesatthetownsvillehospitalqueenslandaretrospectivestudy
AT vasantshenoy the12monthimpactofcontinuousinsulininfusiontherapyonglycaemiccontrolinadultswithtype1diabetesatthetownsvillehospitalqueenslandaretrospectivestudy
AT kunwarjitsangla the12monthimpactofcontinuousinsulininfusiontherapyonglycaemiccontrolinadultswithtype1diabetesatthetownsvillehospitalqueenslandaretrospectivestudy
AT sujiprabhaharan 12monthimpactofcontinuousinsulininfusiontherapyonglycaemiccontrolinadultswithtype1diabetesatthetownsvillehospitalqueenslandaretrospectivestudy
AT vasantshenoy 12monthimpactofcontinuousinsulininfusiontherapyonglycaemiccontrolinadultswithtype1diabetesatthetownsvillehospitalqueenslandaretrospectivestudy
AT kunwarjitsangla 12monthimpactofcontinuousinsulininfusiontherapyonglycaemiccontrolinadultswithtype1diabetesatthetownsvillehospitalqueenslandaretrospectivestudy