Choroid Plexus in Alzheimer’s Disease—The Current State of Knowledge
The choroid plexus (CP), located in each of the four ventricles of the brain, is formed by a monolayer of epithelial cells that surrounds a highly vascularized connective tissue with permeable capillaries. These cells are joined by tight junctions forming the blood–cerebrospinal fluid barrier (BCSFB...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/2/224 |
| _version_ | 1797482565311922176 |
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| author | Tiago Gião Tiago Teixeira Maria Rosário Almeida Isabel Cardoso |
| author_facet | Tiago Gião Tiago Teixeira Maria Rosário Almeida Isabel Cardoso |
| author_sort | Tiago Gião |
| collection | DOAJ |
| description | The choroid plexus (CP), located in each of the four ventricles of the brain, is formed by a monolayer of epithelial cells that surrounds a highly vascularized connective tissue with permeable capillaries. These cells are joined by tight junctions forming the blood–cerebrospinal fluid barrier (BCSFB), which strictly regulates the exchange of substances between the blood and cerebrospinal fluid (CSF). The primary purpose of the CP is to secrete CSF, but it also plays a role in the immune surveillance of the central nervous system (CNS) and in the removal of neurotoxic compounds from the CSF. According to recent findings, the CP is also involved in the modulation of the circadian cycle and neurogenesis. In diseases such as Alzheimer’s disease (AD), the function of the CP is impaired, resulting in an altered secretory, barrier, transport, and immune function. This review describes the current state of knowledge concerning the roles of the CP and BCSFB in the pathophysiology of AD and summarizes recently proposed therapies that aim to restore CP and BCSFB functions. |
| first_indexed | 2024-03-09T22:34:13Z |
| format | Article |
| id | doaj.art-d6c1a14dccb54f138751a2f2e42c8f9f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T22:34:13Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-d6c1a14dccb54f138751a2f2e42c8f9f2023-11-23T18:52:15ZengMDPI AGBiomedicines2227-90592022-01-0110222410.3390/biomedicines10020224Choroid Plexus in Alzheimer’s Disease—The Current State of KnowledgeTiago Gião0Tiago Teixeira1Maria Rosário Almeida2Isabel Cardoso3Molecular Neurobiology Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, PortugalMolecular Neurobiology Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, PortugalMolecular Neurobiology Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, PortugalMolecular Neurobiology Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, PortugalThe choroid plexus (CP), located in each of the four ventricles of the brain, is formed by a monolayer of epithelial cells that surrounds a highly vascularized connective tissue with permeable capillaries. These cells are joined by tight junctions forming the blood–cerebrospinal fluid barrier (BCSFB), which strictly regulates the exchange of substances between the blood and cerebrospinal fluid (CSF). The primary purpose of the CP is to secrete CSF, but it also plays a role in the immune surveillance of the central nervous system (CNS) and in the removal of neurotoxic compounds from the CSF. According to recent findings, the CP is also involved in the modulation of the circadian cycle and neurogenesis. In diseases such as Alzheimer’s disease (AD), the function of the CP is impaired, resulting in an altered secretory, barrier, transport, and immune function. This review describes the current state of knowledge concerning the roles of the CP and BCSFB in the pathophysiology of AD and summarizes recently proposed therapies that aim to restore CP and BCSFB functions.https://www.mdpi.com/2227-9059/10/2/224choroid plexusblood–cerebrospinal fluid barrierAlzheimer’s diseaseneurodegenerative disorderbarrier disruptionnovel therapies |
| spellingShingle | Tiago Gião Tiago Teixeira Maria Rosário Almeida Isabel Cardoso Choroid Plexus in Alzheimer’s Disease—The Current State of Knowledge Biomedicines choroid plexus blood–cerebrospinal fluid barrier Alzheimer’s disease neurodegenerative disorder barrier disruption novel therapies |
| title | Choroid Plexus in Alzheimer’s Disease—The Current State of Knowledge |
| title_full | Choroid Plexus in Alzheimer’s Disease—The Current State of Knowledge |
| title_fullStr | Choroid Plexus in Alzheimer’s Disease—The Current State of Knowledge |
| title_full_unstemmed | Choroid Plexus in Alzheimer’s Disease—The Current State of Knowledge |
| title_short | Choroid Plexus in Alzheimer’s Disease—The Current State of Knowledge |
| title_sort | choroid plexus in alzheimer s disease the current state of knowledge |
| topic | choroid plexus blood–cerebrospinal fluid barrier Alzheimer’s disease neurodegenerative disorder barrier disruption novel therapies |
| url | https://www.mdpi.com/2227-9059/10/2/224 |
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