Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review
Cancer seriously threatens human health. Surgery, radiotherapy and chemotherapy are the three pillars of traditional cancer treatment, with targeted therapy and immunotherapy emerging over recent decades. Standard drug regimens are mostly executed via intravenous injection (IV), especially for chemo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/10/2028 |
| _version_ | 1797470408520237056 |
|---|---|
| author | Juan Zhao Ling Wang Haiwei Zhang Bin Liao Yongsheng Li |
| author_facet | Juan Zhao Ling Wang Haiwei Zhang Bin Liao Yongsheng Li |
| author_sort | Juan Zhao |
| collection | DOAJ |
| description | Cancer seriously threatens human health. Surgery, radiotherapy and chemotherapy are the three pillars of traditional cancer treatment, with targeted therapy and immunotherapy emerging over recent decades. Standard drug regimens are mostly executed via intravenous injection (IV), especially for chemotherapy agents. However, these treatments pose severe risks, including off-target toxic side effects, low drug accumulation and penetration at the tumor site, repeated administration, etc., leading to inadequate treatment and failure to meet patients’ needs. Arising from these challenges, a local regional anticancer strategy has been proposed to enhance therapeutic efficacy and concomitantly reduce systemic toxicity. With the advances in biomaterials and our understanding of the tumor microenvironment, in situ stimulus-responsive hydrogels, also called smart hydrogels, have been extensively investigated for local anticancer therapy due to their injectability, compatibility and responsiveness to various stimuli (pH, enzyme, heat, light, magnetic fields, electric fields etc.). Herein, we focus on the latest progress regarding various stimuli that cause phase transition and drug release from smart hydrogels in local regional anticancer therapy. Additionally, the challenges and future trends of the reviewed in situ smart hydrogels for local drug delivery are summarized and proposed. |
| first_indexed | 2024-03-09T19:35:57Z |
| format | Article |
| id | doaj.art-d6c4933c91504184af622fa958afbf10 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T19:35:57Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d6c4933c91504184af622fa958afbf102023-11-24T01:54:12ZengMDPI AGPharmaceutics1999-49232022-09-011410202810.3390/pharmaceutics14102028Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A ReviewJuan Zhao0Ling Wang1Haiwei Zhang2Bin Liao3Yongsheng Li4Department of Phase I Clinical Trial Center, Chongqing University Cancer Hospital, Chongqing 400030, ChinaDepartment of Phase I Clinical Trial Center, Chongqing University Cancer Hospital, Chongqing 400030, ChinaDepartment of Phase I Clinical Trial Center, Chongqing University Cancer Hospital, Chongqing 400030, ChinaDepartment of Phase I Clinical Trial Center, Chongqing University Cancer Hospital, Chongqing 400030, ChinaDepartment of Phase I Clinical Trial Center, Chongqing University Cancer Hospital, Chongqing 400030, ChinaCancer seriously threatens human health. Surgery, radiotherapy and chemotherapy are the three pillars of traditional cancer treatment, with targeted therapy and immunotherapy emerging over recent decades. Standard drug regimens are mostly executed via intravenous injection (IV), especially for chemotherapy agents. However, these treatments pose severe risks, including off-target toxic side effects, low drug accumulation and penetration at the tumor site, repeated administration, etc., leading to inadequate treatment and failure to meet patients’ needs. Arising from these challenges, a local regional anticancer strategy has been proposed to enhance therapeutic efficacy and concomitantly reduce systemic toxicity. With the advances in biomaterials and our understanding of the tumor microenvironment, in situ stimulus-responsive hydrogels, also called smart hydrogels, have been extensively investigated for local anticancer therapy due to their injectability, compatibility and responsiveness to various stimuli (pH, enzyme, heat, light, magnetic fields, electric fields etc.). Herein, we focus on the latest progress regarding various stimuli that cause phase transition and drug release from smart hydrogels in local regional anticancer therapy. Additionally, the challenges and future trends of the reviewed in situ smart hydrogels for local drug delivery are summarized and proposed.https://www.mdpi.com/1999-4923/14/10/2028in situ hydrogelstimuli responsivelocal regional therapyprogress |
| spellingShingle | Juan Zhao Ling Wang Haiwei Zhang Bin Liao Yongsheng Li Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review Pharmaceutics in situ hydrogel stimuli responsive local regional therapy progress |
| title | Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review |
| title_full | Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review |
| title_fullStr | Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review |
| title_full_unstemmed | Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review |
| title_short | Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review |
| title_sort | progress of research in in situ smart hydrogels for local antitumor therapy a review |
| topic | in situ hydrogel stimuli responsive local regional therapy progress |
| url | https://www.mdpi.com/1999-4923/14/10/2028 |
| work_keys_str_mv | AT juanzhao progressofresearchininsitusmarthydrogelsforlocalantitumortherapyareview AT lingwang progressofresearchininsitusmarthydrogelsforlocalantitumortherapyareview AT haiweizhang progressofresearchininsitusmarthydrogelsforlocalantitumortherapyareview AT binliao progressofresearchininsitusmarthydrogelsforlocalantitumortherapyareview AT yongshengli progressofresearchininsitusmarthydrogelsforlocalantitumortherapyareview |