A comparison of blood stream infections with extended spectrum beta-lactamase-producing and non-producing Klebsiella pneumoniae in pediatric patients
Abstract Background Rapid development and global spread of multidrug resistant Klebsiella pneumonia (K. pneumoniae) as a major cause of nosocomial infections is really remarkable. The aim of this study was to explore risk factors for health care associated blood stream infections (BSI) caused by ESB...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13052-017-0398-0 |
| _version_ | 1811273632055296000 |
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| author | Sevgen Tanır Basaranoglu Yasemin Ozsurekci Kubra Aykac Eda Karadag Oncel Asiye Bıcakcigil Banu Sancak Ali Bulent Cengiz Ates Kara Mehmet Ceyhan |
| author_facet | Sevgen Tanır Basaranoglu Yasemin Ozsurekci Kubra Aykac Eda Karadag Oncel Asiye Bıcakcigil Banu Sancak Ali Bulent Cengiz Ates Kara Mehmet Ceyhan |
| author_sort | Sevgen Tanır Basaranoglu |
| collection | DOAJ |
| description | Abstract Background Rapid development and global spread of multidrug resistant Klebsiella pneumonia (K. pneumoniae) as a major cause of nosocomial infections is really remarkable. The aim of this study was to explore risk factors for health care associated blood stream infections (BSI) caused by ESBL-producing K. pneumoniae in children and analyze clinical outcomes. Methods A retrospective review of patients younger than 18 years-old with blood stream infection caused by K. pneumoniae was performed. Patients with ESBL-producing K. pneumoniae isolates were compared with ESBL-non-producing isolates in terms of risk factors, outcome and mortality. Results Among 111 K. pneumoniae isolates 62% (n = 69) were ESBL –producing K. pneumoniae. The median total length of hospitalization and median length of stay in hospital before infection was significantly higher in patients with ESBL-producing isolates than ESBL-non-producing. Use of combined antimicrobial treatment was significantly different between ESBL-producing and ESBL-non-producing groups, 75.4% and 24.6%, respectively (p = 0.001). Previous aminoglycoside use was higher in cases with ESBL –producing isolates (p = 0.001). Logistic regression analysis showed a significant correlation between mortality and use of combined antibiotics (OR 4.22; p = 0.01). Conclusion ESBL production in K. pneumoniae isolates has a significant impact on clinical course of BSIs. Total length of hospitalization, length of hospital stay before infection, prior combined antibiotic use and use of aminoglycosides were significant risk factors for development of ESBL-producing K. pneumoniae related BSI. |
| first_indexed | 2024-04-12T23:02:51Z |
| format | Article |
| id | doaj.art-d6c4d8fbf4ca44d88d8753b2845ef3f6 |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-04-12T23:02:51Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-d6c4d8fbf4ca44d88d8753b2845ef3f62022-12-22T03:13:00ZengBMCItalian Journal of Pediatrics1824-72882017-09-014311710.1186/s13052-017-0398-0A comparison of blood stream infections with extended spectrum beta-lactamase-producing and non-producing Klebsiella pneumoniae in pediatric patientsSevgen Tanır Basaranoglu0Yasemin Ozsurekci1Kubra Aykac2Eda Karadag Oncel3Asiye Bıcakcigil4Banu Sancak5Ali Bulent Cengiz6Ates Kara7Mehmet Ceyhan8Department of Pediatric Infectious Diseases, Hacettepe University Faculty of MedicineDepartment of Pediatric Infectious Diseases, Hacettepe University Faculty of MedicineDepartment of Pediatric Infectious Diseases, Hacettepe University Faculty of MedicineDepartment of Pediatric Infectious Diseases, Hacettepe University Faculty of MedicineDepartment of Microbiology, Hacettepe University Faculty of MedicineDepartment of Microbiology, Hacettepe University Faculty of MedicineDepartment of Pediatric Infectious Diseases, Hacettepe University Faculty of MedicineDepartment of Pediatric Infectious Diseases, Hacettepe University Faculty of MedicineDepartment of Pediatric Infectious Diseases, Hacettepe University Faculty of MedicineAbstract Background Rapid development and global spread of multidrug resistant Klebsiella pneumonia (K. pneumoniae) as a major cause of nosocomial infections is really remarkable. The aim of this study was to explore risk factors for health care associated blood stream infections (BSI) caused by ESBL-producing K. pneumoniae in children and analyze clinical outcomes. Methods A retrospective review of patients younger than 18 years-old with blood stream infection caused by K. pneumoniae was performed. Patients with ESBL-producing K. pneumoniae isolates were compared with ESBL-non-producing isolates in terms of risk factors, outcome and mortality. Results Among 111 K. pneumoniae isolates 62% (n = 69) were ESBL –producing K. pneumoniae. The median total length of hospitalization and median length of stay in hospital before infection was significantly higher in patients with ESBL-producing isolates than ESBL-non-producing. Use of combined antimicrobial treatment was significantly different between ESBL-producing and ESBL-non-producing groups, 75.4% and 24.6%, respectively (p = 0.001). Previous aminoglycoside use was higher in cases with ESBL –producing isolates (p = 0.001). Logistic regression analysis showed a significant correlation between mortality and use of combined antibiotics (OR 4.22; p = 0.01). Conclusion ESBL production in K. pneumoniae isolates has a significant impact on clinical course of BSIs. Total length of hospitalization, length of hospital stay before infection, prior combined antibiotic use and use of aminoglycosides were significant risk factors for development of ESBL-producing K. pneumoniae related BSI.http://link.springer.com/article/10.1186/s13052-017-0398-0Extended spectrum β lactamaseKlebsiella pneumoniaBlood stream infectionsChildren |
| spellingShingle | Sevgen Tanır Basaranoglu Yasemin Ozsurekci Kubra Aykac Eda Karadag Oncel Asiye Bıcakcigil Banu Sancak Ali Bulent Cengiz Ates Kara Mehmet Ceyhan A comparison of blood stream infections with extended spectrum beta-lactamase-producing and non-producing Klebsiella pneumoniae in pediatric patients Italian Journal of Pediatrics Extended spectrum β lactamase Klebsiella pneumonia Blood stream infections Children |
| title | A comparison of blood stream infections with extended spectrum beta-lactamase-producing and non-producing Klebsiella pneumoniae in pediatric patients |
| title_full | A comparison of blood stream infections with extended spectrum beta-lactamase-producing and non-producing Klebsiella pneumoniae in pediatric patients |
| title_fullStr | A comparison of blood stream infections with extended spectrum beta-lactamase-producing and non-producing Klebsiella pneumoniae in pediatric patients |
| title_full_unstemmed | A comparison of blood stream infections with extended spectrum beta-lactamase-producing and non-producing Klebsiella pneumoniae in pediatric patients |
| title_short | A comparison of blood stream infections with extended spectrum beta-lactamase-producing and non-producing Klebsiella pneumoniae in pediatric patients |
| title_sort | comparison of blood stream infections with extended spectrum beta lactamase producing and non producing klebsiella pneumoniae in pediatric patients |
| topic | Extended spectrum β lactamase Klebsiella pneumonia Blood stream infections Children |
| url | http://link.springer.com/article/10.1186/s13052-017-0398-0 |
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