The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progression
Abstract Background Fc gamma receptor IIb (FcγRIIb) is an important inhibitory receptor that plays vital roles in regulating various immune response processes and the pathogenesis of many infectious diseases. The purpose of our research was to evaluate FcγRIIb expression in serum and liver biopsy sp...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-021-06918-7 |
| _version_ | 1818701324832735232 |
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| author | Jinglan Jin Yuwei Liu Xiaotong Xu Zhongfeng Wang Junqi Niu |
| author_facet | Jinglan Jin Yuwei Liu Xiaotong Xu Zhongfeng Wang Junqi Niu |
| author_sort | Jinglan Jin |
| collection | DOAJ |
| description | Abstract Background Fc gamma receptor IIb (FcγRIIb) is an important inhibitory receptor that plays vital roles in regulating various immune response processes and the pathogenesis of many infectious diseases. The purpose of our research was to evaluate FcγRIIb expression in serum and liver biopsy specimens from hepatitis B virus (HBV)-infected patients and to explore the association of FcγRIIb with chronic HBV infection. Methods Enzyme-linked immunosorbent assay (ELISA) was adopted to measure the serum FcγRIIb levels in 119 HBV-infected patients and 24 healthy controls. An immunohistochemical method was then employed to identify FcγRIIb expression in biopsy specimens from patients with chronic hepatitis B (CHB). The integrated optical density (IOD) value was measured to represent FcγRIIb expression levels. Results Serum FcγRIIb levels were decreased in CHB patients compared to controls (P < 0.001). The FcγRIIb levels in the CHB patient group were remarkably lower than those in the HBV carrier group (P < 0.001). In addition, FcγRIIb levels were negatively associated with AST and ALT (r = −0.3936, P = 0.0063; r = −0.3459, P = 0.0097, respectively). The IOD values of FcγRIIb expression in the moderate and severe CHB groups were significantly lower than those in the control group (P = 0.006 and P < 0.001, respectively). The FcγRIIb level tended to be lower with pathological changes related to hepatitis. Furthermore, correlation analysis revealed that FcγRIIb had negative correlations with AST and ALT (r = −0.688, P = 0.0016; r = −0.686, P = 0.0017, respectively) but a positive association with the platelet count (r = 0.6464, P = 0.0038). Conclusions FcγRIIb levels are significantly related to chronic HBV infection and the progression of CHB. Changes in FcγRIIb may affect the progression of liver inflammation and fibrosis in CHB patients. |
| first_indexed | 2024-12-17T15:19:02Z |
| format | Article |
| id | doaj.art-d6c4e11631fc4c13bd4bc6a971d641f3 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-17T15:19:02Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-d6c4e11631fc4c13bd4bc6a971d641f32022-12-21T21:43:27ZengBMCBMC Infectious Diseases1471-23342021-12-0121111010.1186/s12879-021-06918-7The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progressionJinglan Jin0Yuwei Liu1Xiaotong Xu2Zhongfeng Wang3Junqi Niu4Department of Hepatology, First Bethune Hospital of Jilin UniversityDepartment of Hepatology, First Bethune Hospital of Jilin UniversityDepartment of Hepatology, First Bethune Hospital of Jilin UniversityDepartment of Hepatology, First Bethune Hospital of Jilin UniversityDepartment of Hepatology, First Bethune Hospital of Jilin UniversityAbstract Background Fc gamma receptor IIb (FcγRIIb) is an important inhibitory receptor that plays vital roles in regulating various immune response processes and the pathogenesis of many infectious diseases. The purpose of our research was to evaluate FcγRIIb expression in serum and liver biopsy specimens from hepatitis B virus (HBV)-infected patients and to explore the association of FcγRIIb with chronic HBV infection. Methods Enzyme-linked immunosorbent assay (ELISA) was adopted to measure the serum FcγRIIb levels in 119 HBV-infected patients and 24 healthy controls. An immunohistochemical method was then employed to identify FcγRIIb expression in biopsy specimens from patients with chronic hepatitis B (CHB). The integrated optical density (IOD) value was measured to represent FcγRIIb expression levels. Results Serum FcγRIIb levels were decreased in CHB patients compared to controls (P < 0.001). The FcγRIIb levels in the CHB patient group were remarkably lower than those in the HBV carrier group (P < 0.001). In addition, FcγRIIb levels were negatively associated with AST and ALT (r = −0.3936, P = 0.0063; r = −0.3459, P = 0.0097, respectively). The IOD values of FcγRIIb expression in the moderate and severe CHB groups were significantly lower than those in the control group (P = 0.006 and P < 0.001, respectively). The FcγRIIb level tended to be lower with pathological changes related to hepatitis. Furthermore, correlation analysis revealed that FcγRIIb had negative correlations with AST and ALT (r = −0.688, P = 0.0016; r = −0.686, P = 0.0017, respectively) but a positive association with the platelet count (r = 0.6464, P = 0.0038). Conclusions FcγRIIb levels are significantly related to chronic HBV infection and the progression of CHB. Changes in FcγRIIb may affect the progression of liver inflammation and fibrosis in CHB patients.https://doi.org/10.1186/s12879-021-06918-7FcγRIIbHBV infectionChronic hepatitis B |
| spellingShingle | Jinglan Jin Yuwei Liu Xiaotong Xu Zhongfeng Wang Junqi Niu The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progression BMC Infectious Diseases FcγRIIb HBV infection Chronic hepatitis B |
| title | The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progression |
| title_full | The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progression |
| title_fullStr | The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progression |
| title_full_unstemmed | The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progression |
| title_short | The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progression |
| title_sort | association between fc gamma riib expression levels and chronic hepatitis b virus infection progression |
| topic | FcγRIIb HBV infection Chronic hepatitis B |
| url | https://doi.org/10.1186/s12879-021-06918-7 |
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