Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?—A Perspective Paper
The present perspective paper addresses and discusses whether cognitive dysfunction in bipolar disorder qualifies as a diagnostic intermediate phenotype using the Robin and Guze criteria of diagnostic validity. The paper reviews current data within (1) delineation of the clinical intermediate phenot...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00490/full |
| _version_ | 1818154034700222464 |
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| author | Lars Vedel Kessing Kamilla Miskowiak Kamilla Miskowiak |
| author_facet | Lars Vedel Kessing Kamilla Miskowiak Kamilla Miskowiak |
| author_sort | Lars Vedel Kessing |
| collection | DOAJ |
| description | The present perspective paper addresses and discusses whether cognitive dysfunction in bipolar disorder qualifies as a diagnostic intermediate phenotype using the Robin and Guze criteria of diagnostic validity. The paper reviews current data within (1) delineation of the clinical intermediate phenotype, (2) associations of the intermediate phenotype with para-clinical data such as brain imaging and blood-based data, (3) associations to family history / genetics, (4) characteristics during long-term follow-up, and (5) treatment effects on cognition. In this way, the paper identifies knowledge gaps and suggests recommendations for future research within each of the five areas. Based on the current state of knowledge, we conclude that cognitive dysfunction does not qualify as a diagnostic intermediate phenotype or endophenotype for bipolar disorder, although promising new evidence points to emotion and reward processing abnormalities as possible putative endophenotypes. |
| first_indexed | 2024-12-11T14:20:06Z |
| format | Article |
| id | doaj.art-d6c6bb4f166245d3a84a5de613eca77c |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-11T14:20:06Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-d6c6bb4f166245d3a84a5de613eca77c2022-12-22T01:02:58ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-10-01910.3389/fpsyt.2018.00490381755Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?—A Perspective PaperLars Vedel Kessing0Kamilla Miskowiak1Kamilla Miskowiak2Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, University Hospital of Copenhagen and University of Copenhagen, Copenhagen, DenmarkCopenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, University Hospital of Copenhagen and University of Copenhagen, Copenhagen, DenmarkDepartment of Psychology, University of Copenhagen, Copenhagen, DenmarkThe present perspective paper addresses and discusses whether cognitive dysfunction in bipolar disorder qualifies as a diagnostic intermediate phenotype using the Robin and Guze criteria of diagnostic validity. The paper reviews current data within (1) delineation of the clinical intermediate phenotype, (2) associations of the intermediate phenotype with para-clinical data such as brain imaging and blood-based data, (3) associations to family history / genetics, (4) characteristics during long-term follow-up, and (5) treatment effects on cognition. In this way, the paper identifies knowledge gaps and suggests recommendations for future research within each of the five areas. Based on the current state of knowledge, we conclude that cognitive dysfunction does not qualify as a diagnostic intermediate phenotype or endophenotype for bipolar disorder, although promising new evidence points to emotion and reward processing abnormalities as possible putative endophenotypes.https://www.frontiersin.org/article/10.3389/fpsyt.2018.00490/fullcognitioncognitive dysfunctionbipolar disorderunipolar disorderschizophreniaintermediate phenotype |
| spellingShingle | Lars Vedel Kessing Kamilla Miskowiak Kamilla Miskowiak Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?—A Perspective Paper Frontiers in Psychiatry cognition cognitive dysfunction bipolar disorder unipolar disorder schizophrenia intermediate phenotype |
| title | Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?—A Perspective Paper |
| title_full | Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?—A Perspective Paper |
| title_fullStr | Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?—A Perspective Paper |
| title_full_unstemmed | Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?—A Perspective Paper |
| title_short | Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?—A Perspective Paper |
| title_sort | does cognitive dysfunction in bipolar disorder qualify as a diagnostic intermediate phenotype a perspective paper |
| topic | cognition cognitive dysfunction bipolar disorder unipolar disorder schizophrenia intermediate phenotype |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00490/full |
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