Initial Hyperleukocytosis and Neutrophilia in Nasopharyngeal Carcinoma: Incidence and Prognostic Impact.
BACKGROUND:This study aimed to evaluate initial hyperleukocytosis and neutrophilia as prognostic indicators in patients with nasopharyngeal carcinoma. METHODS:A retrospective analysis of 5,854 patients identified from a cohort of 6,035 patients diagnosed with nasopharyngeal carcinoma was performed w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4559377?pdf=render |
| _version_ | 1818205472480559104 |
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| author | Zhen Su Yan-Ping Mao Pu-Yun OuYang Jie Tang Fang-Yun Xie |
| author_facet | Zhen Su Yan-Ping Mao Pu-Yun OuYang Jie Tang Fang-Yun Xie |
| author_sort | Zhen Su |
| collection | DOAJ |
| description | BACKGROUND:This study aimed to evaluate initial hyperleukocytosis and neutrophilia as prognostic indicators in patients with nasopharyngeal carcinoma. METHODS:A retrospective analysis of 5,854 patients identified from a cohort of 6,035 patients diagnosed with nasopharyngeal carcinoma was performed with initial hyperleukocytosis and neutrophilia analyzed as prognostic factors. Multivariate Cox proportional hazards analyses were applied. RESULTS:Hyperleukocytosis was observed in 508 patients (8.7%). Multivariate analysis showed that initial hyperleukocytosis was an independent predictor of death (HR 1.40, 95%CI 1.15-1.70, p = 0.001), progression (HR 1.25, 95%CI 1.06-1.47, p = 0.007) and, marginally, distant metastasis (HR 1.21, 95%CI 0.97-1.52, p = 0.088). Neutrophilia was also an independent predictor of death (HR 1.46, 95%CI 1.18-1.81, p = 0.001), progression (HR 1.31, 95%CI 1.10-1.56, p = 0.003), and distant metastasis (HR 1.29, 95%CI 1.02-1.65, p = 0.036), after adjusting for prognostic factors and excluding hyperleukocytosis. CONCLUSION:Initial hyperleukocytosis and neutrophilia were independent, poor prognostic factors and may be convenient and useful biological markers for survival of patients with nasopharyngeal carcinoma. |
| first_indexed | 2024-12-12T03:57:41Z |
| format | Article |
| id | doaj.art-d6c73f1d40974ce58eb4a13a32f11a59 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T03:57:41Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d6c73f1d40974ce58eb4a13a32f11a592022-12-22T00:39:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01109e013675210.1371/journal.pone.0136752Initial Hyperleukocytosis and Neutrophilia in Nasopharyngeal Carcinoma: Incidence and Prognostic Impact.Zhen SuYan-Ping MaoPu-Yun OuYangJie TangFang-Yun XieBACKGROUND:This study aimed to evaluate initial hyperleukocytosis and neutrophilia as prognostic indicators in patients with nasopharyngeal carcinoma. METHODS:A retrospective analysis of 5,854 patients identified from a cohort of 6,035 patients diagnosed with nasopharyngeal carcinoma was performed with initial hyperleukocytosis and neutrophilia analyzed as prognostic factors. Multivariate Cox proportional hazards analyses were applied. RESULTS:Hyperleukocytosis was observed in 508 patients (8.7%). Multivariate analysis showed that initial hyperleukocytosis was an independent predictor of death (HR 1.40, 95%CI 1.15-1.70, p = 0.001), progression (HR 1.25, 95%CI 1.06-1.47, p = 0.007) and, marginally, distant metastasis (HR 1.21, 95%CI 0.97-1.52, p = 0.088). Neutrophilia was also an independent predictor of death (HR 1.46, 95%CI 1.18-1.81, p = 0.001), progression (HR 1.31, 95%CI 1.10-1.56, p = 0.003), and distant metastasis (HR 1.29, 95%CI 1.02-1.65, p = 0.036), after adjusting for prognostic factors and excluding hyperleukocytosis. CONCLUSION:Initial hyperleukocytosis and neutrophilia were independent, poor prognostic factors and may be convenient and useful biological markers for survival of patients with nasopharyngeal carcinoma.http://europepmc.org/articles/PMC4559377?pdf=render |
| spellingShingle | Zhen Su Yan-Ping Mao Pu-Yun OuYang Jie Tang Fang-Yun Xie Initial Hyperleukocytosis and Neutrophilia in Nasopharyngeal Carcinoma: Incidence and Prognostic Impact. PLoS ONE |
| title | Initial Hyperleukocytosis and Neutrophilia in Nasopharyngeal Carcinoma: Incidence and Prognostic Impact. |
| title_full | Initial Hyperleukocytosis and Neutrophilia in Nasopharyngeal Carcinoma: Incidence and Prognostic Impact. |
| title_fullStr | Initial Hyperleukocytosis and Neutrophilia in Nasopharyngeal Carcinoma: Incidence and Prognostic Impact. |
| title_full_unstemmed | Initial Hyperleukocytosis and Neutrophilia in Nasopharyngeal Carcinoma: Incidence and Prognostic Impact. |
| title_short | Initial Hyperleukocytosis and Neutrophilia in Nasopharyngeal Carcinoma: Incidence and Prognostic Impact. |
| title_sort | initial hyperleukocytosis and neutrophilia in nasopharyngeal carcinoma incidence and prognostic impact |
| url | http://europepmc.org/articles/PMC4559377?pdf=render |
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