A short translational ramp determines the efficiency of protein synthesis
Several factors contribute to the efficiency of protein expression. Here the authors show that the identity of amino acids encoded by codons at position 3–5 significantly impact translation efficiency and protein expression levels.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13810-1 |
| _version_ | 1818425608419409920 |
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| author | Manasvi Verma Junhong Choi Kyle A. Cottrell Zeno Lavagnino Erica N. Thomas Slavica Pavlovic-Djuranovic Pawel Szczesny David W. Piston Hani S. Zaher Joseph D. Puglisi Sergej Djuranovic |
| author_facet | Manasvi Verma Junhong Choi Kyle A. Cottrell Zeno Lavagnino Erica N. Thomas Slavica Pavlovic-Djuranovic Pawel Szczesny David W. Piston Hani S. Zaher Joseph D. Puglisi Sergej Djuranovic |
| author_sort | Manasvi Verma |
| collection | DOAJ |
| description | Several factors contribute to the efficiency of protein expression. Here the authors show that the identity of amino acids encoded by codons at position 3–5 significantly impact translation efficiency and protein expression levels. |
| first_indexed | 2024-12-14T14:16:39Z |
| format | Article |
| id | doaj.art-d6c7739bcd3d4753818faecc0bc65dc2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:16:39Z |
| publishDate | 2019-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d6c7739bcd3d4753818faecc0bc65dc22022-12-21T22:58:11ZengNature PortfolioNature Communications2041-17232019-12-0110111510.1038/s41467-019-13810-1A short translational ramp determines the efficiency of protein synthesisManasvi Verma0Junhong Choi1Kyle A. Cottrell2Zeno Lavagnino3Erica N. Thomas4Slavica Pavlovic-Djuranovic5Pawel Szczesny6David W. Piston7Hani S. Zaher8Joseph D. Puglisi9Sergej Djuranovic10Department of Cell Biology and Physiology, Washington University School of MedicineDepartment of Structural Biology, Stanford University School of MedicineDepartment of Cell Biology and Physiology, Washington University School of MedicineDepartment of Cell Biology and Physiology, Washington University School of MedicineDepartment of Biology, Washington UniversityDepartment of Cell Biology and Physiology, Washington University School of MedicineDepartment of Bioinformatics, Institute of Biochemistry and Biophysics Polish Academy of SciencesDepartment of Cell Biology and Physiology, Washington University School of MedicineDepartment of Biology, Washington UniversityDepartment of Structural Biology, Stanford University School of MedicineDepartment of Cell Biology and Physiology, Washington University School of MedicineSeveral factors contribute to the efficiency of protein expression. Here the authors show that the identity of amino acids encoded by codons at position 3–5 significantly impact translation efficiency and protein expression levels.https://doi.org/10.1038/s41467-019-13810-1 |
| spellingShingle | Manasvi Verma Junhong Choi Kyle A. Cottrell Zeno Lavagnino Erica N. Thomas Slavica Pavlovic-Djuranovic Pawel Szczesny David W. Piston Hani S. Zaher Joseph D. Puglisi Sergej Djuranovic A short translational ramp determines the efficiency of protein synthesis Nature Communications |
| title | A short translational ramp determines the efficiency of protein synthesis |
| title_full | A short translational ramp determines the efficiency of protein synthesis |
| title_fullStr | A short translational ramp determines the efficiency of protein synthesis |
| title_full_unstemmed | A short translational ramp determines the efficiency of protein synthesis |
| title_short | A short translational ramp determines the efficiency of protein synthesis |
| title_sort | short translational ramp determines the efficiency of protein synthesis |
| url | https://doi.org/10.1038/s41467-019-13810-1 |
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