Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatin that reflect nucleosome organisation.
High-throughput sequencing technology is central to our current understanding of the human methylome. The vast majority of studies use chemical conversion to analyse bulk-level patterns of DNA methylation across the genome from a population of cells. While this technology has been used to probe sing...
Main Authors: | Lyndsay Kerr, Ioannis Kafetzopoulos, Ramon Grima, Duncan Sproul |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-10-01
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Series: | PLoS Genetics |
Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010958&type=printable |
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