Non-coding RNAs regulation of macrophage polarization in cancer
Abstract Noncoding RNA (ncRNA) transcripts that did not code proteins but regulate their functions were extensively studied for the last two decades and the plethora of discoveries have instigated scientists to investigate their dynamic roles in several diseases especially in cancer. However, there...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-021-01313-x |
| _version_ | 1818326750138990592 |
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| author | Swati Mohapatra Carlotta Pioppini Bulent Ozpolat George A. Calin |
| author_facet | Swati Mohapatra Carlotta Pioppini Bulent Ozpolat George A. Calin |
| author_sort | Swati Mohapatra |
| collection | DOAJ |
| description | Abstract Noncoding RNA (ncRNA) transcripts that did not code proteins but regulate their functions were extensively studied for the last two decades and the plethora of discoveries have instigated scientists to investigate their dynamic roles in several diseases especially in cancer. However, there is much more to learn about the role of ncRNAs as drivers of malignant cell evolution in relation to macrophage polarization in the tumor microenvironment. At the initial stage of tumor development, macrophages have an important role in directing Go/No-go decisions to the promotion of tumor growth, immunosuppression, and angiogenesis. Tumor-associated macrophages behave differently as they are predominantly induced to be polarized into M2, a pro-tumorigenic type when recruited with the tumor tissue and thereby favoring the tumorigenesis. Polarization of macrophages into M1 or M2 subtypes plays a vital role in regulating tumor progression, metastasis, and clinical outcome, highlighting the importance of studying the factors driving this process. A substantial number of studies have demonstrated that ncRNAs are involved in the macrophage polarization based on their ability to drive M1 or M2 polarization and in this review we have described their functions and categorized them into oncogenes, tumor suppressors, Juggling tumor suppressors, and Juggling oncogenes. |
| first_indexed | 2024-12-13T12:05:20Z |
| format | Article |
| id | doaj.art-d6c7ed8f43b74eb5a384120162156b62 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-13T12:05:20Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-d6c7ed8f43b74eb5a384120162156b622022-12-21T23:46:58ZengBMCMolecular Cancer1476-45982021-02-0120111510.1186/s12943-021-01313-xNon-coding RNAs regulation of macrophage polarization in cancerSwati Mohapatra0Carlotta Pioppini1Bulent Ozpolat2George A. Calin3Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterAbstract Noncoding RNA (ncRNA) transcripts that did not code proteins but regulate their functions were extensively studied for the last two decades and the plethora of discoveries have instigated scientists to investigate their dynamic roles in several diseases especially in cancer. However, there is much more to learn about the role of ncRNAs as drivers of malignant cell evolution in relation to macrophage polarization in the tumor microenvironment. At the initial stage of tumor development, macrophages have an important role in directing Go/No-go decisions to the promotion of tumor growth, immunosuppression, and angiogenesis. Tumor-associated macrophages behave differently as they are predominantly induced to be polarized into M2, a pro-tumorigenic type when recruited with the tumor tissue and thereby favoring the tumorigenesis. Polarization of macrophages into M1 or M2 subtypes plays a vital role in regulating tumor progression, metastasis, and clinical outcome, highlighting the importance of studying the factors driving this process. A substantial number of studies have demonstrated that ncRNAs are involved in the macrophage polarization based on their ability to drive M1 or M2 polarization and in this review we have described their functions and categorized them into oncogenes, tumor suppressors, Juggling tumor suppressors, and Juggling oncogenes.https://doi.org/10.1186/s12943-021-01313-xMacrophagesMicroRNAsLong noncoding RNAsPolarizationCancer |
| spellingShingle | Swati Mohapatra Carlotta Pioppini Bulent Ozpolat George A. Calin Non-coding RNAs regulation of macrophage polarization in cancer Molecular Cancer Macrophages MicroRNAs Long noncoding RNAs Polarization Cancer |
| title | Non-coding RNAs regulation of macrophage polarization in cancer |
| title_full | Non-coding RNAs regulation of macrophage polarization in cancer |
| title_fullStr | Non-coding RNAs regulation of macrophage polarization in cancer |
| title_full_unstemmed | Non-coding RNAs regulation of macrophage polarization in cancer |
| title_short | Non-coding RNAs regulation of macrophage polarization in cancer |
| title_sort | non coding rnas regulation of macrophage polarization in cancer |
| topic | Macrophages MicroRNAs Long noncoding RNAs Polarization Cancer |
| url | https://doi.org/10.1186/s12943-021-01313-x |
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