Impaired iron recycling from erythrocytes is an early hallmark of aging

Impaired iron recycling from erythrocytes is an early hallmark of aging

Aging affects iron homeostasis, as evidenced by tissue iron loading and anemia in the elderly. Iron needs in mammals are met primarily by iron recycling from senescent red blood cells (RBCs), a task chiefly accomplished by splenic red pulp macrophages (RPMs) via erythrophagocytosis. Given that RPMs...

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Bibliographic Details
Main Authors: Patryk Slusarczyk, Pratik Kumar Mandal, Gabriela Zurawska, Marta Niklewicz, Komal Chouhan, Raghunandan Mahadeva, Aneta Jończy, Matylda Macias, Aleksandra Szybinska, Magdalena Cybulska-Lubak, Olga Krawczyk, Sylwia Herman, Michal Mikula, Remigiusz Serwa, Małgorzata Lenartowicz, Wojciech Pokrzywa, Katarzyna Mleczko-Sanecka
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
hepcidin
ferroportin
proteostasis
Online Access:https://elifesciences.org/articles/79196

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