Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats
Abstract Bisphenol A (BPA) is one of the most common worldwide chemicals involved in the industry of polycarbonate plastics, medical devices, and pharmaceuticals. Forty three-month-old albino rats were randomly classified into four groups. Group Ӏ received a daily corn oil dose (5 mL/kg/ body weight...
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| Format: | Article |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-14158-1 |
| _version_ | 1811343440867229696 |
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| author | Omnia Ibrahim Ismail Manal Mahmoud Samy El-Meligy |
| author_facet | Omnia Ibrahim Ismail Manal Mahmoud Samy El-Meligy |
| author_sort | Omnia Ibrahim Ismail |
| collection | DOAJ |
| description | Abstract Bisphenol A (BPA) is one of the most common worldwide chemicals involved in the industry of polycarbonate plastics, medical devices, and pharmaceuticals. Forty three-month-old albino rats were randomly classified into four groups. Group Ӏ received a daily corn oil dose (5 mL/kg/ body weight, BW) through a gastric tube for one month, Group ӀӀ received a daily dose of Curcumin (200 mg/kg body weight (B.W.) through a gastric tube for one month, Group ӀӀӀ received a daily dose of BPA (0.5 μg/kg B.W.) through a gastric tube for one month and Group ӀV received concomitant daily doses of Bisphenol A and Curcumin as the regimen described in groups ӀӀ and ӀӀӀ. The rats were sacrificed, and glandular portion of stomach was dissected and processed for light, immunohistochemical and ultrastructural study. BPA induced destructed gastric glands, dilated congested blood vessels, submucosal oedema, decreased PAS-positive reactivity, increased collagen fibres deposition, decrease in the positive BCL2 immunoexpression, increased positive PCNA immunoexpression, reduction in the gastric mucosal height and destructive changes in the enteroendocrine, chief and parietal cells. Curcumin coadministration provoked an obvious improvement in the gastric structure. BPA exposure has toxic effects on the glandular portion of the stomach in rats. Otherwise, Curcumin coadministration has exhibited protective impact on the architecture of the stomach. |
| first_indexed | 2024-04-13T19:30:28Z |
| format | Article |
| id | doaj.art-d6c99b80617d4114ac8a2365073123b7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T19:30:28Z |
| publishDate | 2022-06-01 |
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| spelling | doaj.art-d6c99b80617d4114ac8a2365073123b72022-12-22T02:33:13ZengNature PortfolioScientific Reports2045-23222022-06-0112111510.1038/s41598-022-14158-1Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino ratsOmnia Ibrahim Ismail0Manal Mahmoud Samy El-Meligy1Human Anatomy and Embryology Department, Faculty of Medicine, Assiut UniversityHuman Anatomy and Embryology Department, Faculty of Medicine, Suez UniversityAbstract Bisphenol A (BPA) is one of the most common worldwide chemicals involved in the industry of polycarbonate plastics, medical devices, and pharmaceuticals. Forty three-month-old albino rats were randomly classified into four groups. Group Ӏ received a daily corn oil dose (5 mL/kg/ body weight, BW) through a gastric tube for one month, Group ӀӀ received a daily dose of Curcumin (200 mg/kg body weight (B.W.) through a gastric tube for one month, Group ӀӀӀ received a daily dose of BPA (0.5 μg/kg B.W.) through a gastric tube for one month and Group ӀV received concomitant daily doses of Bisphenol A and Curcumin as the regimen described in groups ӀӀ and ӀӀӀ. The rats were sacrificed, and glandular portion of stomach was dissected and processed for light, immunohistochemical and ultrastructural study. BPA induced destructed gastric glands, dilated congested blood vessels, submucosal oedema, decreased PAS-positive reactivity, increased collagen fibres deposition, decrease in the positive BCL2 immunoexpression, increased positive PCNA immunoexpression, reduction in the gastric mucosal height and destructive changes in the enteroendocrine, chief and parietal cells. Curcumin coadministration provoked an obvious improvement in the gastric structure. BPA exposure has toxic effects on the glandular portion of the stomach in rats. Otherwise, Curcumin coadministration has exhibited protective impact on the architecture of the stomach.https://doi.org/10.1038/s41598-022-14158-1 |
| spellingShingle | Omnia Ibrahim Ismail Manal Mahmoud Samy El-Meligy Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats Scientific Reports |
| title | Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats |
| title_full | Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats |
| title_fullStr | Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats |
| title_full_unstemmed | Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats |
| title_short | Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats |
| title_sort | curcumin ameliorated low dose bisphenol a induced gastric toxicity in adult albino rats |
| url | https://doi.org/10.1038/s41598-022-14158-1 |
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