Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases
Chronic inflammation plays a significant role in lifestyle-related diseases, such as cardiovascular diseases and obesity/impaired glucose tolerance. Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. The mechanisms underlying...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2019-07-01
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| Series: | European Cardiology Review |
| Online Access: | https://www.ecrjournal.com/articles/anti-inflammatory-action-curcumin-use |
| _version_ | 1797200146399756288 |
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| author | Kana Shimizu Masafumi Funamoto Yoichi Sunagawa Satoshi Shimizu Yasufumi Katanasaka Yusuke Miyazaki Hiromichi Wada Koji Hasegawa Tatsuya Morimoto |
| author_facet | Kana Shimizu Masafumi Funamoto Yoichi Sunagawa Satoshi Shimizu Yasufumi Katanasaka Yusuke Miyazaki Hiromichi Wada Koji Hasegawa Tatsuya Morimoto |
| author_sort | Kana Shimizu |
| collection | DOAJ |
| description | Chronic inflammation plays a significant role in lifestyle-related diseases, such as cardiovascular diseases and obesity/impaired glucose tolerance. Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. The mechanisms underlying these effects include the inhibition of nuclear factor-kappaB and Toll-like receptor 4-dependent signalling pathways and the activation of a peroxisome proliferator-activated receptor-gamma pathway. However, the bioavailability of curcumin is very low in humans. To resolve this issue, several drug delivery systems have been developed and a number of clinical trials have reported beneficial effects of curcumin in the management of inflammation-related diseases. It is expected that evidence regarding the clinical application of curcumin in lifestyle-related diseases associated with chronic inflammation will accumulate over time. |
| first_indexed | 2024-03-07T17:42:21Z |
| format | Article |
| id | doaj.art-d6c9b3f2fc46444f8f0fb0730eb6f66b |
| institution | Directory Open Access Journal |
| issn | 1758-3756 1758-3764 |
| language | English |
| last_indexed | 2024-04-24T07:27:01Z |
| publishDate | 2019-07-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | European Cardiology Review |
| spelling | doaj.art-d6c9b3f2fc46444f8f0fb0730eb6f66b2024-04-20T16:01:22ZengRadcliffe Medical MediaEuropean Cardiology Review1758-37561758-37642019-07-0114211712210.15420/ecr.2019.17.2Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related DiseasesKana Shimizu0Masafumi Funamoto1Yoichi Sunagawa2Satoshi Shimizu3Yasufumi Katanasaka4Yusuke Miyazaki5Hiromichi Wada6Koji Hasegawa7Tatsuya Morimoto8Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, JapanClinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, JapanChronic inflammation plays a significant role in lifestyle-related diseases, such as cardiovascular diseases and obesity/impaired glucose tolerance. Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. The mechanisms underlying these effects include the inhibition of nuclear factor-kappaB and Toll-like receptor 4-dependent signalling pathways and the activation of a peroxisome proliferator-activated receptor-gamma pathway. However, the bioavailability of curcumin is very low in humans. To resolve this issue, several drug delivery systems have been developed and a number of clinical trials have reported beneficial effects of curcumin in the management of inflammation-related diseases. It is expected that evidence regarding the clinical application of curcumin in lifestyle-related diseases associated with chronic inflammation will accumulate over time.https://www.ecrjournal.com/articles/anti-inflammatory-action-curcumin-use |
| spellingShingle | Kana Shimizu Masafumi Funamoto Yoichi Sunagawa Satoshi Shimizu Yasufumi Katanasaka Yusuke Miyazaki Hiromichi Wada Koji Hasegawa Tatsuya Morimoto Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases European Cardiology Review |
| title | Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases |
| title_full | Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases |
| title_fullStr | Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases |
| title_full_unstemmed | Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases |
| title_short | Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases |
| title_sort | anti inflammatory action of curcumin and its use in the treatment of lifestyle related diseases |
| url | https://www.ecrjournal.com/articles/anti-inflammatory-action-curcumin-use |
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