EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION
The article describes the safety and efficiency evaluation of chemotherapy regimens containing bedaquiline used in 23 tuberculosis patients with multiple and extensive drug resistance in Amur Region. Treatment with bedaquiline (24 weeks) and other anti-tuberculosis drugs was highly effective based o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2018-07-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1135 |
| _version_ | 1826563074452094976 |
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| author | L. Yu. Tikhonova V. V. Sokolova I. A. Tarasyuk A. M. Ekimenko M. A. Cherenkova D. A. Kudlay |
| author_facet | L. Yu. Tikhonova V. V. Sokolova I. A. Tarasyuk A. M. Ekimenko M. A. Cherenkova D. A. Kudlay |
| author_sort | L. Yu. Tikhonova |
| collection | DOAJ |
| description | The article describes the safety and efficiency evaluation of chemotherapy regimens containing bedaquiline used in 23 tuberculosis patients with multiple and extensive drug resistance in Amur Region. Treatment with bedaquiline (24 weeks) and other anti-tuberculosis drugs was highly effective based on sputum conversion criteria: sputum microscopy – 86.7% (13/15; 95% CI 62.1-96.3%), culture ‒ 82.6%, (19/23; 95% CI 62.7-93.0%), and cavity healing ‒ 73.9% (17/23; 95% CI 53.6-87.5%), of them patients with previous treatment failure made 43.6% (10/23). The best outcomes were achieved in the patients with new tuberculosis and relapses. A satisfactory safety profile was demonstrated during this trial piloting chemotherapy regimens containing bedaquiline, no cardiac toxicity was registered. |
| first_indexed | 2024-03-12T04:19:24Z |
| format | Article |
| id | doaj.art-d6d1f1d6d761443f9718ec648b105265 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2025-03-14T09:58:11Z |
| publishDate | 2018-07-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-d6d1f1d6d761443f9718ec648b1052652025-03-02T11:22:28ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062018-07-01966455010.21292/2075-1230-2018-96-6-45-501135EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGIONL. Yu. Tikhonova0V. V. Sokolova1I. A. Tarasyuk2A. M. Ekimenko3M. A. Cherenkova4D. A. Kudlay5Amur Regional TB DispensaryAmur Regional TB DispensaryAmur Regional TB DispensaryAmur Regional TB DispensaryAmur Regional TB DispensaryProfessional Development Institute by the Russian Federal Medical Biological AgencyThe article describes the safety and efficiency evaluation of chemotherapy regimens containing bedaquiline used in 23 tuberculosis patients with multiple and extensive drug resistance in Amur Region. Treatment with bedaquiline (24 weeks) and other anti-tuberculosis drugs was highly effective based on sputum conversion criteria: sputum microscopy – 86.7% (13/15; 95% CI 62.1-96.3%), culture ‒ 82.6%, (19/23; 95% CI 62.7-93.0%), and cavity healing ‒ 73.9% (17/23; 95% CI 53.6-87.5%), of them patients with previous treatment failure made 43.6% (10/23). The best outcomes were achieved in the patients with new tuberculosis and relapses. A satisfactory safety profile was demonstrated during this trial piloting chemotherapy regimens containing bedaquiline, no cardiac toxicity was registered.https://www.tibl-journal.com/jour/article/view/1135multiple drug resistance of tuberculous mycobacteriabedaquilinetreatment efficiencytuberculosis treatment |
| spellingShingle | L. Yu. Tikhonova V. V. Sokolova I. A. Tarasyuk A. M. Ekimenko M. A. Cherenkova D. A. Kudlay EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION Туберкулез и болезни лёгких multiple drug resistance of tuberculous mycobacteria bedaquiline treatment efficiency tuberculosis treatment |
| title | EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION |
| title_full | EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION |
| title_fullStr | EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION |
| title_full_unstemmed | EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION |
| title_short | EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION |
| title_sort | experience of treatment of multiple drug resistant tuberculosis patients with bedaquiline in amur region |
| topic | multiple drug resistance of tuberculous mycobacteria bedaquiline treatment efficiency tuberculosis treatment |
| url | https://www.tibl-journal.com/jour/article/view/1135 |
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