Impact of long COVID on the heart rate variability at rest and during deep breathing maneuver
Abstract While the majority of individuals with coronavirus disease 2019 (COVID-19) recover completely, a significant percentage experience persistent symptom, which has been characterized as Long COVID and may be associated with cardiac and autonomic dysfunction. We evaluated heart rate variability...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-50276-0 |
| _version_ | 1797377076815200256 |
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| author | Andréa Lúcia Gonçalves da Silva Luana dos Passos Vieira Luiza Scheffer Dias Cecília Vieira Prestes Guilherme Dionir Back Cassia da Luz Goulart Ross Arena Audrey Borghi-Silva Renata Trimer |
| author_facet | Andréa Lúcia Gonçalves da Silva Luana dos Passos Vieira Luiza Scheffer Dias Cecília Vieira Prestes Guilherme Dionir Back Cassia da Luz Goulart Ross Arena Audrey Borghi-Silva Renata Trimer |
| author_sort | Andréa Lúcia Gonçalves da Silva |
| collection | DOAJ |
| description | Abstract While the majority of individuals with coronavirus disease 2019 (COVID-19) recover completely, a significant percentage experience persistent symptom, which has been characterized as Long COVID and may be associated with cardiac and autonomic dysfunction. We evaluated heart rate variability (HRV) at rest and during deep-breathing (M-RSA) in patients with Long COVID. Case–control design involved 21 patients with Long COVID and 20 controls; the HRV was evaluated (POLAR system) at rest in the supine position and during M-RSA and expressed in time domain and non-linear analysis. In the supine position we found a reduction HRV measures in Long COVID’ patients compared to controls for: Mean_iRR (p < 0.001), STD_iRR (p < 0.001); STD_HR (p < 0.001); SD1 (p < 0.001); SD2 (p < 0.001); alpha2 (p < 0.001). In the M-RSA we found reduction Mean_iRR (p < 0.001), STD_iRR (p < 0.001), STD_HR (p < 0.001), rMSSD (p < 0.001), RR_tri-index (p < 0.001) in Long COVID’ patients except for highest Mean_HR p < 0.001. In conclusion, Long COVID reduced HRV at rest and during deep breathing. These findings may imply impairment of cardiac autonomic control when symptoms of COVID-19 persist following initial recovery. |
| first_indexed | 2024-03-08T19:47:48Z |
| format | Article |
| id | doaj.art-d6d3fdb1bdde4237aa8eeff73060a0fa |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T19:47:48Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d6d3fdb1bdde4237aa8eeff73060a0fa2023-12-24T12:15:39ZengNature PortfolioScientific Reports2045-23222023-12-011311710.1038/s41598-023-50276-0Impact of long COVID on the heart rate variability at rest and during deep breathing maneuverAndréa Lúcia Gonçalves da Silva0Luana dos Passos Vieira1Luiza Scheffer Dias2Cecília Vieira Prestes3Guilherme Dionir Back4Cassia da Luz Goulart5Ross Arena6Audrey Borghi-Silva7Renata Trimer8Department of Health Sciences, University of Santa Cruz do SulScientific Initiation Scholarship at Laboratory of Cardiorespiratory Rehabilitation, University of Santa Cruz do SulScientific Initiation Scholarship at Laboratory of Cardiorespiratory Rehabilitation, University of Santa Cruz do SulScientific Initiation Scholarship at Laboratory of Cardiorespiratory Rehabilitation, University of Santa Cruz do SulCardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of São Carlos (UFSCar)Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of São Carlos (UFSCar)Department of Physical Therapy, College of Applied Health Sciences, University of Illinois ChicagoCardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of São Carlos (UFSCar)Department of Health Sciences, University of Santa Cruz do SulAbstract While the majority of individuals with coronavirus disease 2019 (COVID-19) recover completely, a significant percentage experience persistent symptom, which has been characterized as Long COVID and may be associated with cardiac and autonomic dysfunction. We evaluated heart rate variability (HRV) at rest and during deep-breathing (M-RSA) in patients with Long COVID. Case–control design involved 21 patients with Long COVID and 20 controls; the HRV was evaluated (POLAR system) at rest in the supine position and during M-RSA and expressed in time domain and non-linear analysis. In the supine position we found a reduction HRV measures in Long COVID’ patients compared to controls for: Mean_iRR (p < 0.001), STD_iRR (p < 0.001); STD_HR (p < 0.001); SD1 (p < 0.001); SD2 (p < 0.001); alpha2 (p < 0.001). In the M-RSA we found reduction Mean_iRR (p < 0.001), STD_iRR (p < 0.001), STD_HR (p < 0.001), rMSSD (p < 0.001), RR_tri-index (p < 0.001) in Long COVID’ patients except for highest Mean_HR p < 0.001. In conclusion, Long COVID reduced HRV at rest and during deep breathing. These findings may imply impairment of cardiac autonomic control when symptoms of COVID-19 persist following initial recovery.https://doi.org/10.1038/s41598-023-50276-0 |
| spellingShingle | Andréa Lúcia Gonçalves da Silva Luana dos Passos Vieira Luiza Scheffer Dias Cecília Vieira Prestes Guilherme Dionir Back Cassia da Luz Goulart Ross Arena Audrey Borghi-Silva Renata Trimer Impact of long COVID on the heart rate variability at rest and during deep breathing maneuver Scientific Reports |
| title | Impact of long COVID on the heart rate variability at rest and during deep breathing maneuver |
| title_full | Impact of long COVID on the heart rate variability at rest and during deep breathing maneuver |
| title_fullStr | Impact of long COVID on the heart rate variability at rest and during deep breathing maneuver |
| title_full_unstemmed | Impact of long COVID on the heart rate variability at rest and during deep breathing maneuver |
| title_short | Impact of long COVID on the heart rate variability at rest and during deep breathing maneuver |
| title_sort | impact of long covid on the heart rate variability at rest and during deep breathing maneuver |
| url | https://doi.org/10.1038/s41598-023-50276-0 |
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