The hepatoprotective effect of Cheral as anti-oxidant and anti-inflammation on mice (Mus musculus) with breast cancer
Introduction: Recent studies have reported that breast cancer may affect the physiology of other organs, including oxidative stress in the liver. On the other hand, some agents such as white turmeric (Curcuma longa) and Meniran (Phyllanthus niruri) seem to maintain redox stability and immunomodulati...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahrekord University of Medical Sciences
2020-03-01
|
| Series: | Journal of HerbMed Pharmacology |
| Subjects: | |
| Online Access: | http://herbmedpharmacol.com/PDF/jhp-9-153.pdf |
| _version_ | 1798016853504688128 |
|---|---|
| author | Feri Eko Hermanto Aris Soewondo Hideo Tsuboi Mansur Ibrahim Muhaimin Rifa'i |
| author_facet | Feri Eko Hermanto Aris Soewondo Hideo Tsuboi Mansur Ibrahim Muhaimin Rifa'i |
| author_sort | Feri Eko Hermanto |
| collection | DOAJ |
| description | Introduction: Recent studies have reported that breast cancer may affect the physiology of other organs, including oxidative stress in the liver. On the other hand, some agents such as white turmeric (Curcuma longa) and Meniran (Phyllanthus niruri) seem to maintain redox stability and immunomodulation. Both of them are combined into Cheral potion. This study was aimed to investigate the Cheral efficacy in modulating oxidative stress based on Nuclear factor erythroid 2-related factor 2 (Nrf2), HEME OXIGenase (HO), and superoxide dismutase (SOD) levels as well as pro-inflammatory cytokines under breast cancer condition in vivo. Methods: Nrf2, HO, and SOD from hepatocytes, and tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) from splenocytes were measured by flow cytometry after 14 days of Cheral administration. Results: The results showed that mice model for breast cancer underwent oxidative stress denoted by high levels of HO, and SOD accompanied by increased levels of TNF-α and IFN-γ in the cancer group compared to normal healthy group (P<0.05). In contrast, Cheral treatment was able to modulate redox balance by declining levels of HO, SOD, TNF-α, and IFN-γ, but not Nrf2, compared to cancer group (P<0.05). Conclusion: The results showed that breast cancer could alter the host’s physiology, including liver oxidative stress. The levels of TNF-α and IFN-γ might contribute to regulation of redox balance in the liver. However, Cheral has potency as an alternative therapeutic agent to reduce oxidative stress in the liver under breast cancer condition. |
| first_indexed | 2024-04-11T15:56:16Z |
| format | Article |
| id | doaj.art-d6d4ae2bc93741229c5c9e9b8097998a |
| institution | Directory Open Access Journal |
| issn | 2345-5004 |
| language | English |
| last_indexed | 2024-04-11T15:56:16Z |
| publishDate | 2020-03-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of HerbMed Pharmacology |
| spelling | doaj.art-d6d4ae2bc93741229c5c9e9b8097998a2022-12-22T04:15:09ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042020-03-019215316010.34172/jhp.2020.20jhp-29508The hepatoprotective effect of Cheral as anti-oxidant and anti-inflammation on mice (Mus musculus) with breast cancerFeri Eko Hermanto0Aris Soewondo1Hideo Tsuboi2Mansur Ibrahim3Muhaimin Rifa'i4Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran Malang 65145, East Java, IndonesiaBiology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran Malang 65145, East Java, IndonesiaDepartment of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, JapanPancasakti University, Makasar 90132, South Sulawesi, IndonesiaBiology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran Malang 65145, East Java, IndonesiaIntroduction: Recent studies have reported that breast cancer may affect the physiology of other organs, including oxidative stress in the liver. On the other hand, some agents such as white turmeric (Curcuma longa) and Meniran (Phyllanthus niruri) seem to maintain redox stability and immunomodulation. Both of them are combined into Cheral potion. This study was aimed to investigate the Cheral efficacy in modulating oxidative stress based on Nuclear factor erythroid 2-related factor 2 (Nrf2), HEME OXIGenase (HO), and superoxide dismutase (SOD) levels as well as pro-inflammatory cytokines under breast cancer condition in vivo. Methods: Nrf2, HO, and SOD from hepatocytes, and tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) from splenocytes were measured by flow cytometry after 14 days of Cheral administration. Results: The results showed that mice model for breast cancer underwent oxidative stress denoted by high levels of HO, and SOD accompanied by increased levels of TNF-α and IFN-γ in the cancer group compared to normal healthy group (P<0.05). In contrast, Cheral treatment was able to modulate redox balance by declining levels of HO, SOD, TNF-α, and IFN-γ, but not Nrf2, compared to cancer group (P<0.05). Conclusion: The results showed that breast cancer could alter the host’s physiology, including liver oxidative stress. The levels of TNF-α and IFN-γ might contribute to regulation of redox balance in the liver. However, Cheral has potency as an alternative therapeutic agent to reduce oxidative stress in the liver under breast cancer condition.http://herbmedpharmacol.com/PDF/jhp-9-153.pdfbreast cancercheralliver oxidative stressproinflammatory cytokines |
| spellingShingle | Feri Eko Hermanto Aris Soewondo Hideo Tsuboi Mansur Ibrahim Muhaimin Rifa'i The hepatoprotective effect of Cheral as anti-oxidant and anti-inflammation on mice (Mus musculus) with breast cancer Journal of HerbMed Pharmacology breast cancer cheral liver oxidative stress proinflammatory cytokines |
| title | The hepatoprotective effect of Cheral as anti-oxidant and anti-inflammation on mice (Mus musculus) with breast cancer |
| title_full | The hepatoprotective effect of Cheral as anti-oxidant and anti-inflammation on mice (Mus musculus) with breast cancer |
| title_fullStr | The hepatoprotective effect of Cheral as anti-oxidant and anti-inflammation on mice (Mus musculus) with breast cancer |
| title_full_unstemmed | The hepatoprotective effect of Cheral as anti-oxidant and anti-inflammation on mice (Mus musculus) with breast cancer |
| title_short | The hepatoprotective effect of Cheral as anti-oxidant and anti-inflammation on mice (Mus musculus) with breast cancer |
| title_sort | hepatoprotective effect of cheral as anti oxidant and anti inflammation on mice mus musculus with breast cancer |
| topic | breast cancer cheral liver oxidative stress proinflammatory cytokines |
| url | http://herbmedpharmacol.com/PDF/jhp-9-153.pdf |
| work_keys_str_mv | AT feriekohermanto thehepatoprotectiveeffectofcheralasantioxidantandantiinflammationonmicemusmusculuswithbreastcancer AT arissoewondo thehepatoprotectiveeffectofcheralasantioxidantandantiinflammationonmicemusmusculuswithbreastcancer AT hideotsuboi thehepatoprotectiveeffectofcheralasantioxidantandantiinflammationonmicemusmusculuswithbreastcancer AT mansuribrahim thehepatoprotectiveeffectofcheralasantioxidantandantiinflammationonmicemusmusculuswithbreastcancer AT muhaiminrifai thehepatoprotectiveeffectofcheralasantioxidantandantiinflammationonmicemusmusculuswithbreastcancer AT feriekohermanto hepatoprotectiveeffectofcheralasantioxidantandantiinflammationonmicemusmusculuswithbreastcancer AT arissoewondo hepatoprotectiveeffectofcheralasantioxidantandantiinflammationonmicemusmusculuswithbreastcancer AT hideotsuboi hepatoprotectiveeffectofcheralasantioxidantandantiinflammationonmicemusmusculuswithbreastcancer AT mansuribrahim hepatoprotectiveeffectofcheralasantioxidantandantiinflammationonmicemusmusculuswithbreastcancer AT muhaiminrifai hepatoprotectiveeffectofcheralasantioxidantandantiinflammationonmicemusmusculuswithbreastcancer |