Non-invasive brain neuromodulation techniques for chronic low back pain
Structural and functional changes of the brain occur in many chronic pain conditions, including chronic low back pain (CLBP), and these brain abnormalities can be reversed by effective treatment. Research on the clinical applications of non-invasive brain neuromodulation (NIBS) techniques for chroni...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.1032617/full |
| _version_ | 1828142985430171648 |
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| author | Tian-Tian Chang Yu-Hao Chang Shu-Hao Du Pei-Jie Chen Xue-Qiang Wang Xue-Qiang Wang Xue-Qiang Wang |
| author_facet | Tian-Tian Chang Yu-Hao Chang Shu-Hao Du Pei-Jie Chen Xue-Qiang Wang Xue-Qiang Wang Xue-Qiang Wang |
| author_sort | Tian-Tian Chang |
| collection | DOAJ |
| description | Structural and functional changes of the brain occur in many chronic pain conditions, including chronic low back pain (CLBP), and these brain abnormalities can be reversed by effective treatment. Research on the clinical applications of non-invasive brain neuromodulation (NIBS) techniques for chronic pain is increasing. Unfortunately, little is known about the effectiveness of NIBS on CLBP, which limits its application in clinical pain management. Therefore, we summarized the effectiveness and limitations of NIBS techniques on CLBP management and described the effects and mechanisms of NIBS approaches on CLBP in this review. Overall, NIBS may be effective for the treatment of CLBP. And the analgesic mechanisms of NIBS for CLBP may involve the regulation of pain signal pathway, synaptic plasticity, neuroprotective effect, neuroinflammation modulation, and variations in cerebral blood flow and metabolism. Current NIBS studies for CLBP have limitations, such as small sample size, relative low quality of evidence, and lack of mechanistic studies. Further studies on the effect of NIBS are needed, especially randomized controlled trials with high quality and large sample size. |
| first_indexed | 2024-04-11T19:49:39Z |
| format | Article |
| id | doaj.art-d6d4f4b1e39c461c99f4185360068b46 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-11T19:49:39Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-d6d4f4b1e39c461c99f4185360068b462022-12-22T04:06:20ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992022-10-011510.3389/fnmol.2022.10326171032617Non-invasive brain neuromodulation techniques for chronic low back painTian-Tian Chang0Yu-Hao Chang1Shu-Hao Du2Pei-Jie Chen3Xue-Qiang Wang4Xue-Qiang Wang5Xue-Qiang Wang6Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Luoyang Postgraduate Training, Henan University of Traditional Chinese Medicine, Luoyang, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai Shangti Orthopaedic Hospital, Shanghai, ChinaShanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, ChinaStructural and functional changes of the brain occur in many chronic pain conditions, including chronic low back pain (CLBP), and these brain abnormalities can be reversed by effective treatment. Research on the clinical applications of non-invasive brain neuromodulation (NIBS) techniques for chronic pain is increasing. Unfortunately, little is known about the effectiveness of NIBS on CLBP, which limits its application in clinical pain management. Therefore, we summarized the effectiveness and limitations of NIBS techniques on CLBP management and described the effects and mechanisms of NIBS approaches on CLBP in this review. Overall, NIBS may be effective for the treatment of CLBP. And the analgesic mechanisms of NIBS for CLBP may involve the regulation of pain signal pathway, synaptic plasticity, neuroprotective effect, neuroinflammation modulation, and variations in cerebral blood flow and metabolism. Current NIBS studies for CLBP have limitations, such as small sample size, relative low quality of evidence, and lack of mechanistic studies. Further studies on the effect of NIBS are needed, especially randomized controlled trials with high quality and large sample size.https://www.frontiersin.org/articles/10.3389/fnmol.2022.1032617/fullpainmechanismsbrain neuromodulationrTMStDCSlow back pain |
| spellingShingle | Tian-Tian Chang Yu-Hao Chang Shu-Hao Du Pei-Jie Chen Xue-Qiang Wang Xue-Qiang Wang Xue-Qiang Wang Non-invasive brain neuromodulation techniques for chronic low back pain Frontiers in Molecular Neuroscience pain mechanisms brain neuromodulation rTMS tDCS low back pain |
| title | Non-invasive brain neuromodulation techniques for chronic low back pain |
| title_full | Non-invasive brain neuromodulation techniques for chronic low back pain |
| title_fullStr | Non-invasive brain neuromodulation techniques for chronic low back pain |
| title_full_unstemmed | Non-invasive brain neuromodulation techniques for chronic low back pain |
| title_short | Non-invasive brain neuromodulation techniques for chronic low back pain |
| title_sort | non invasive brain neuromodulation techniques for chronic low back pain |
| topic | pain mechanisms brain neuromodulation rTMS tDCS low back pain |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.1032617/full |
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