Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model.

Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model.

<h4>Background</h4>Current gene- and cell-based therapies have significant limitations which impede widespread clinical application. Taking diabetes mellitus as a paradigm, we have sought to overcome these limitations by ex vivo electrotransfer of a nonviral insulin expression vector int...

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Main Authors: Nelson K F Chen, Jen San Wong, Irene H C Kee, Siang Hui Lai, Choon Hua Thng, Wai Har Ng, Robert T H Ng, Soo Yong Tan, Shu Yen Lee, Mark E H Tan, Jaichandran Sivalingam, Pierce K H Chow, Oi Lian Kon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-03-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18320053/?tool=EBI

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