Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult

Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult

Objective: Mitochondrial pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, and NADH production. As a result, the mitochondrial pyruvate carrier (MPC) complex has emerged as a promising therapeutic target in metabolic diseases. Clinical trials are currently underway. How...

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Bibliographic Details
Main Authors: Nicole K.H. Yiew, Joel H. Vazquez, Michael R. Martino, Stefanie Kennon-McGill, Jake R. Price, Felicia D. Allard, Eric U. Yee, Alexander J. Layman, Laura P. James, Kyle S. McCommis, Brian N. Finck, Mitchell R. McGill
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Molecular Metabolism
Subjects:
Acetaminophen
Diabetes
Glutathione
Liver
Metabolism
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823001424

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