Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization
In this review, we tried to systematize all the evidence (from PubMed [MEDLINE], Scopus, Cochrane Library, EBSCO, Embase, and Google Scholar) from 1993 to 2021 on the predictors of microsurgical varicocelectomy efficacy in male infertility treatment. Regarding the outcomes of varicocele repair, we c...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2023;volume=25;issue=1;spage=21;epage=28;aulast=Shomarufov |
| _version_ | 1828014201115770880 |
|---|---|
| author | Azizbek B Shomarufov Vladimir A Bozhedomov Nikolay I Sorokin Igor P Matyukhov Abdukodir A Fozilov Shukhrat A Abbosov Armais A Kamalov |
| author_facet | Azizbek B Shomarufov Vladimir A Bozhedomov Nikolay I Sorokin Igor P Matyukhov Abdukodir A Fozilov Shukhrat A Abbosov Armais A Kamalov |
| author_sort | Azizbek B Shomarufov |
| collection | DOAJ |
| description | In this review, we tried to systematize all the evidence (from PubMed [MEDLINE], Scopus, Cochrane Library, EBSCO, Embase, and Google Scholar) from 1993 to 2021 on the predictors of microsurgical varicocelectomy efficacy in male infertility treatment. Regarding the outcomes of varicocele repair, we considered semen improvement and pregnancy and analyzed them separately. Based on the 2011 Oxford CEBM Levels of Evidence, we assigned a score to each trial that studied the role of the predictor. We systematized the studied predictors based on the total points, which were, in turn, calculated based on the number and quality of studies that confirmed or rejected the studied predictor as significant, into three levels of significance: predictors of high, moderate, and low clinical significance. Preoperative total motile sperm count (TMSC) coupled with sperm concentration can be a significant predictor of semen improvement and pregnancy after varicocelectomy. In addition, for semen improvement alone, scrotal Doppler ultrasound (DUS) parameters, sperm DNA fragmentation index (DFI), and bilateral varicocelectomy are reliable predictors of microsurgical varicocelectomy efficacy. |
| first_indexed | 2024-04-10T09:58:11Z |
| format | Article |
| id | doaj.art-d6d7f894a823434e9a2e2f19b80ca138 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-04-10T09:58:11Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-d6d7f894a823434e9a2e2f19b80ca1382023-02-16T12:09:20ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622023-01-01251212810.4103/aja2021125Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematizationAzizbek B ShomarufovVladimir A BozhedomovNikolay I SorokinIgor P MatyukhovAbdukodir A FozilovShukhrat A AbbosovArmais A KamalovIn this review, we tried to systematize all the evidence (from PubMed [MEDLINE], Scopus, Cochrane Library, EBSCO, Embase, and Google Scholar) from 1993 to 2021 on the predictors of microsurgical varicocelectomy efficacy in male infertility treatment. Regarding the outcomes of varicocele repair, we considered semen improvement and pregnancy and analyzed them separately. Based on the 2011 Oxford CEBM Levels of Evidence, we assigned a score to each trial that studied the role of the predictor. We systematized the studied predictors based on the total points, which were, in turn, calculated based on the number and quality of studies that confirmed or rejected the studied predictor as significant, into three levels of significance: predictors of high, moderate, and low clinical significance. Preoperative total motile sperm count (TMSC) coupled with sperm concentration can be a significant predictor of semen improvement and pregnancy after varicocelectomy. In addition, for semen improvement alone, scrotal Doppler ultrasound (DUS) parameters, sperm DNA fragmentation index (DFI), and bilateral varicocelectomy are reliable predictors of microsurgical varicocelectomy efficacy.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2023;volume=25;issue=1;spage=21;epage=28;aulast=Shomarufovmale infertility; microsurgical varicocelectomy; predictor; pregnancy; semen; varicocele |
| spellingShingle | Azizbek B Shomarufov Vladimir A Bozhedomov Nikolay I Sorokin Igor P Matyukhov Abdukodir A Fozilov Shukhrat A Abbosov Armais A Kamalov Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization Asian Journal of Andrology male infertility; microsurgical varicocelectomy; predictor; pregnancy; semen; varicocele |
| title | Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization |
| title_full | Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization |
| title_fullStr | Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization |
| title_full_unstemmed | Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization |
| title_short | Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization |
| title_sort | predictors of microsurgical varicocelectomy efficacy in male infertility treatment critical assessment and systematization |
| topic | male infertility; microsurgical varicocelectomy; predictor; pregnancy; semen; varicocele |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2023;volume=25;issue=1;spage=21;epage=28;aulast=Shomarufov |
| work_keys_str_mv | AT azizbekbshomarufov predictorsofmicrosurgicalvaricocelectomyefficacyinmaleinfertilitytreatmentcriticalassessmentandsystematization AT vladimirabozhedomov predictorsofmicrosurgicalvaricocelectomyefficacyinmaleinfertilitytreatmentcriticalassessmentandsystematization AT nikolayisorokin predictorsofmicrosurgicalvaricocelectomyefficacyinmaleinfertilitytreatmentcriticalassessmentandsystematization AT igorpmatyukhov predictorsofmicrosurgicalvaricocelectomyefficacyinmaleinfertilitytreatmentcriticalassessmentandsystematization AT abdukodirafozilov predictorsofmicrosurgicalvaricocelectomyefficacyinmaleinfertilitytreatmentcriticalassessmentandsystematization AT shukhrataabbosov predictorsofmicrosurgicalvaricocelectomyefficacyinmaleinfertilitytreatmentcriticalassessmentandsystematization AT armaisakamalov predictorsofmicrosurgicalvaricocelectomyefficacyinmaleinfertilitytreatmentcriticalassessmentandsystematization |