Dynamic Boolean modeling of molecular and cellular interactions in psoriasis predicts drug target candidates

Dynamic Boolean modeling of molecular and cellular interactions in psoriasis predicts drug target candidates

Summary: Psoriasis arises from complex interactions between keratinocytes and immune cells, leading to uncontrolled inflammation, immune hyperactivation, and a perturbed keratinocyte life cycle. Despite the availability of drugs for psoriasis management, the disease remains incurable. Treatment resp...

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Bibliographic Details
Main Authors: Eirini Tsirvouli, Vincent Noël, Åsmund Flobak, Laurence Calzone, Martin Kuiper
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Medicine
Disease
Drugs
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224000804

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