Viral Gastroenteritis: Sickness Symptoms and Behavioral Responses
ABSTRACT Viral infections have a major impact on physiology and behavior. The clinical symptoms of human rotavirus and norovirus infection are primarily diarrhea, fever, and vomiting, but several other sickness symptoms, such as nausea, loss of appetite, and stress response are never or rarely discu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2023-04-01
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| Series: | mBio |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mbio.03567-22 |
| _version_ | 1797839577069649920 |
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| author | Arash Hellysaz Magdalena Neijd Timo Vesikari Lennart Svensson Marie Hagbom |
| author_facet | Arash Hellysaz Magdalena Neijd Timo Vesikari Lennart Svensson Marie Hagbom |
| author_sort | Arash Hellysaz |
| collection | DOAJ |
| description | ABSTRACT Viral infections have a major impact on physiology and behavior. The clinical symptoms of human rotavirus and norovirus infection are primarily diarrhea, fever, and vomiting, but several other sickness symptoms, such as nausea, loss of appetite, and stress response are never or rarely discussed. These physiological and behavioral changes can be considered as having evolved to reduce the spread of the pathogen and increase the chances of survival of the individual as well as the collective. The mechanisms underlying several sickness symptoms have been shown to be orchestrated by the brain, specifically, the hypothalamus. In this perspective, we have described how the central nervous system contributes to the mechanisms underlying the sickness symptoms and behaviors of these infections. Based on published findings, we propose a mechanistic model depicting the role of the brain in fever, nausea, vomiting, cortisol-induced stress, and loss of appetite. |
| first_indexed | 2024-04-09T16:00:02Z |
| format | Article |
| id | doaj.art-d6dc403fc7c24181a9f72f1ffc1e7ca3 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-04-09T16:00:02Z |
| publishDate | 2023-04-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-d6dc403fc7c24181a9f72f1ffc1e7ca32023-04-25T13:04:57ZengAmerican Society for MicrobiologymBio2150-75112023-04-0114210.1128/mbio.03567-22Viral Gastroenteritis: Sickness Symptoms and Behavioral ResponsesArash Hellysaz0Magdalena Neijd1Timo Vesikari2Lennart Svensson3Marie Hagbom4Division of Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, SwedenDivision of Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, SwedenNordic Research Network Oy, Tampere, FinlandDivision of Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, SwedenDivision of Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, SwedenABSTRACT Viral infections have a major impact on physiology and behavior. The clinical symptoms of human rotavirus and norovirus infection are primarily diarrhea, fever, and vomiting, but several other sickness symptoms, such as nausea, loss of appetite, and stress response are never or rarely discussed. These physiological and behavioral changes can be considered as having evolved to reduce the spread of the pathogen and increase the chances of survival of the individual as well as the collective. The mechanisms underlying several sickness symptoms have been shown to be orchestrated by the brain, specifically, the hypothalamus. In this perspective, we have described how the central nervous system contributes to the mechanisms underlying the sickness symptoms and behaviors of these infections. Based on published findings, we propose a mechanistic model depicting the role of the brain in fever, nausea, vomiting, cortisol-induced stress, and loss of appetite.https://journals.asm.org/doi/10.1128/mbio.03567-22rotavirusnorovirussickness symptomsbrainhypothalamusbehavioral responses |
| spellingShingle | Arash Hellysaz Magdalena Neijd Timo Vesikari Lennart Svensson Marie Hagbom Viral Gastroenteritis: Sickness Symptoms and Behavioral Responses mBio rotavirus norovirus sickness symptoms brain hypothalamus behavioral responses |
| title | Viral Gastroenteritis: Sickness Symptoms and Behavioral Responses |
| title_full | Viral Gastroenteritis: Sickness Symptoms and Behavioral Responses |
| title_fullStr | Viral Gastroenteritis: Sickness Symptoms and Behavioral Responses |
| title_full_unstemmed | Viral Gastroenteritis: Sickness Symptoms and Behavioral Responses |
| title_short | Viral Gastroenteritis: Sickness Symptoms and Behavioral Responses |
| title_sort | viral gastroenteritis sickness symptoms and behavioral responses |
| topic | rotavirus norovirus sickness symptoms brain hypothalamus behavioral responses |
| url | https://journals.asm.org/doi/10.1128/mbio.03567-22 |
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