Potential Therapeutic Targets in Ovarian Cancer: Autophagy and Metabolism
Ovarian cancer (OC) is characterized by high mortality rates owing to late diagnosis and resistance to chemotherapy. Autophagy and metabolism play essential roles in the pathological process of cancer and have recently been proposed as potential targets for anticancer therapies. Autophagy is respons...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-03-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/28/3/10.31083/j.fbl2803047 |
| _version_ | 1797853550457389056 |
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| author | Misung Park Soohyun Choe Miyoung Shin Ayoung Kim Kyumin Mo Hyeonseok Kwon Hyunho Yoon |
| author_facet | Misung Park Soohyun Choe Miyoung Shin Ayoung Kim Kyumin Mo Hyeonseok Kwon Hyunho Yoon |
| author_sort | Misung Park |
| collection | DOAJ |
| description | Ovarian cancer (OC) is characterized by high mortality rates owing to late diagnosis and resistance to chemotherapy. Autophagy and metabolism play essential roles in the pathological process of cancer and have recently been proposed as potential targets for anticancer therapies. Autophagy is responsible for the catabolic clearance of functionally misfolded proteins and plays different roles depending on the stage and type of cancer. Thus, understanding and controlling autophagy is relevant for treating cancer. Autophagy intermediates can communicate with each other by providing substrates for glucose, amino acid, and lipid metabolism. Metabolites and metabolic regulatory genes modulate autophagy and influence the immune response. Therefore, autophagy and the functional manipulation of metabolism during starvation or overnutrition are being investigated as potential therapeutic targets. This review discusses the role of autophagy and metabolism in OC and highlights effective therapeutic strategies targeting these processes. |
| first_indexed | 2024-04-09T19:51:20Z |
| format | Article |
| id | doaj.art-d6dcf42ab41649e2b3d78d8c02760265 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-04-09T19:51:20Z |
| publishDate | 2023-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-d6dcf42ab41649e2b3d78d8c027602652023-04-03T05:52:10ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-03-012834710.31083/j.fbl2803047S2768-6701(23)00818-3Potential Therapeutic Targets in Ovarian Cancer: Autophagy and MetabolismMisung Park0Soohyun Choe1Miyoung Shin2Ayoung Kim3Kyumin Mo4Hyeonseok Kwon5Hyunho Yoon6Department of Medical and Biological Sciences, The Catholic University of Korea, 14662 Bucheon, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, 14662 Bucheon, Republic of KoreaDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510, USADepartment of Medical and Biological Sciences, The Catholic University of Korea, 14662 Bucheon, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, 14662 Bucheon, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, 14662 Bucheon, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, 14662 Bucheon, Republic of KoreaOvarian cancer (OC) is characterized by high mortality rates owing to late diagnosis and resistance to chemotherapy. Autophagy and metabolism play essential roles in the pathological process of cancer and have recently been proposed as potential targets for anticancer therapies. Autophagy is responsible for the catabolic clearance of functionally misfolded proteins and plays different roles depending on the stage and type of cancer. Thus, understanding and controlling autophagy is relevant for treating cancer. Autophagy intermediates can communicate with each other by providing substrates for glucose, amino acid, and lipid metabolism. Metabolites and metabolic regulatory genes modulate autophagy and influence the immune response. Therefore, autophagy and the functional manipulation of metabolism during starvation or overnutrition are being investigated as potential therapeutic targets. This review discusses the role of autophagy and metabolism in OC and highlights effective therapeutic strategies targeting these processes.https://www.imrpress.com/journal/FBL/28/3/10.31083/j.fbl2803047ovarian cancerautophagymetabolismmetabolitescancer therapeutics |
| spellingShingle | Misung Park Soohyun Choe Miyoung Shin Ayoung Kim Kyumin Mo Hyeonseok Kwon Hyunho Yoon Potential Therapeutic Targets in Ovarian Cancer: Autophagy and Metabolism Frontiers in Bioscience-Landmark ovarian cancer autophagy metabolism metabolites cancer therapeutics |
| title | Potential Therapeutic Targets in Ovarian Cancer: Autophagy and Metabolism |
| title_full | Potential Therapeutic Targets in Ovarian Cancer: Autophagy and Metabolism |
| title_fullStr | Potential Therapeutic Targets in Ovarian Cancer: Autophagy and Metabolism |
| title_full_unstemmed | Potential Therapeutic Targets in Ovarian Cancer: Autophagy and Metabolism |
| title_short | Potential Therapeutic Targets in Ovarian Cancer: Autophagy and Metabolism |
| title_sort | potential therapeutic targets in ovarian cancer autophagy and metabolism |
| topic | ovarian cancer autophagy metabolism metabolites cancer therapeutics |
| url | https://www.imrpress.com/journal/FBL/28/3/10.31083/j.fbl2803047 |
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