Immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus: A path to potential biomarkers
Systemic lupus erythematosus (SLE) patients display an increased risk of cardiovascular disease (CVD). With the improved clinical management of other classical severe manifestation of the disease, CVD is becoming one of the most relevant complications of SLE, and it is an important factor causing mo...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.974826/full |
| _version_ | 1811212944604659712 |
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| author | Gabriela Guzmán-Martínez Gabriela Guzmán-Martínez Gabriela Guzmán-Martínez Concepción Marañón CYTED RIBLES Network Ana María Blasini Víctor González-Rumayor Roberto Muñoz-Louis Bernardo A. Pons-Estel Guillermo Pons-Estel Rosana Quintana Martín A. Rodríguez Manuel F. Ugarte-Gil Gloria Vásquez |
| author_facet | Gabriela Guzmán-Martínez Gabriela Guzmán-Martínez Gabriela Guzmán-Martínez Concepción Marañón CYTED RIBLES Network Ana María Blasini Víctor González-Rumayor Roberto Muñoz-Louis Bernardo A. Pons-Estel Guillermo Pons-Estel Rosana Quintana Martín A. Rodríguez Manuel F. Ugarte-Gil Gloria Vásquez |
| author_sort | Gabriela Guzmán-Martínez |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) patients display an increased risk of cardiovascular disease (CVD). With the improved clinical management of other classical severe manifestation of the disease, CVD is becoming one of the most relevant complications of SLE, and it is an important factor causing morbidity and mortality. Several immune constituents have been shown to be involved in the pathogenesis of atherosclerosis and endothelial damage in SLE patients, including specific circulating cell populations, autoantibodies, and inflammatory mediators. In this review, we summarize the presentation of CVD in SLE and the role of the autoimmune responses present in SLE patients in the induction of atherogenesis, endothelial impairment and cardiac disease. Additionally, we discuss the utility of these immune mediators as early CVD biomarkers and targets for clinical intervention in SLE patients. |
| first_indexed | 2024-04-12T05:38:10Z |
| format | Article |
| id | doaj.art-d6dde961fcaf4407a38b2a79dc8f70d7 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T05:38:10Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d6dde961fcaf4407a38b2a79dc8f70d72022-12-22T03:45:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.974826974826Immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus: A path to potential biomarkersGabriela Guzmán-Martínez0Gabriela Guzmán-Martínez1Gabriela Guzmán-Martínez2Concepción Marañón3CYTED RIBLES NetworkAna María BlasiniVíctor González-RumayorRoberto Muñoz-LouisBernardo A. Pons-EstelGuillermo Pons-EstelRosana QuintanaMartín A. RodríguezManuel F. Ugarte-GilGloria VásquezAtrys Health, Madrid, SpainDepartment of Medicine, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, SpainDepartment of Cardiology, La Paz University Hospital, IdiPaz, Madrid, SpainDepartment of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, SpainSystemic lupus erythematosus (SLE) patients display an increased risk of cardiovascular disease (CVD). With the improved clinical management of other classical severe manifestation of the disease, CVD is becoming one of the most relevant complications of SLE, and it is an important factor causing morbidity and mortality. Several immune constituents have been shown to be involved in the pathogenesis of atherosclerosis and endothelial damage in SLE patients, including specific circulating cell populations, autoantibodies, and inflammatory mediators. In this review, we summarize the presentation of CVD in SLE and the role of the autoimmune responses present in SLE patients in the induction of atherogenesis, endothelial impairment and cardiac disease. Additionally, we discuss the utility of these immune mediators as early CVD biomarkers and targets for clinical intervention in SLE patients.https://www.frontiersin.org/articles/10.3389/fimmu.2022.974826/fullsystemic lupus erythematosuscardiovascular diseaseinflammationcytokinesautoantibodiesbiomarkers |
| spellingShingle | Gabriela Guzmán-Martínez Gabriela Guzmán-Martínez Gabriela Guzmán-Martínez Concepción Marañón CYTED RIBLES Network Ana María Blasini Víctor González-Rumayor Roberto Muñoz-Louis Bernardo A. Pons-Estel Guillermo Pons-Estel Rosana Quintana Martín A. Rodríguez Manuel F. Ugarte-Gil Gloria Vásquez Immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus: A path to potential biomarkers Frontiers in Immunology systemic lupus erythematosus cardiovascular disease inflammation cytokines autoantibodies biomarkers |
| title | Immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus: A path to potential biomarkers |
| title_full | Immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus: A path to potential biomarkers |
| title_fullStr | Immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus: A path to potential biomarkers |
| title_full_unstemmed | Immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus: A path to potential biomarkers |
| title_short | Immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus: A path to potential biomarkers |
| title_sort | immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus a path to potential biomarkers |
| topic | systemic lupus erythematosus cardiovascular disease inflammation cytokines autoantibodies biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.974826/full |
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